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Preparation method of medical adhesive with high antibacterial performance

An adhesive and performance technology, applied in the field of high antibacterial performance medical adhesive and its preparation, can solve the problem that biomedical materials do not have bacterial immune function, affect the effect and application of medical adhesive, bacterial adhesion and reproduction, etc. problems, to achieve the effect of safe and reliable mechanical properties, easy processing, and good mechanical properties

Active Publication Date: 2018-08-28
浙江派菲特新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main research direction of medical adhesives is to improve the bonding strength of various adhesives. However, the biomedical materials currently used in surgical operations do not have the function of bacterial immunity, and are prone to bacterial adhesion and reproduction, becoming a source of infection in surrounding tissues. , bringing huge mental and economic pressure to patients, endowing medical materials with antibacterial activity is the only effective way to solve this problem
The production of formaldehyde during the storage and use of cyanoacrylate medical adhesives has side effects on biological tissues, and with the increase of formaldehyde concentration, the damage to organisms increases, which seriously affects the effect and application of medical adhesives

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] A medical adhesive with high antibacterial performance, comprising the following components in parts by weight:

[0066] 45 parts of poly(isobutyl α-cyanoacrylate-α-octyl cyanoacrylate), 24 parts of high-efficiency antibacterial components, 2 parts of polyurethane, 20 parts of polyisoprene, 2 parts of sodium alginate, 3 parts of lignin 7 parts of tannic acid, 1 part of stabilizer, 1 part of formaldehyde inhibitor, 150 parts of seabuckthorn seed oil, 180 parts of sterile water; high-efficiency antibacterial components include 5 parts of special-effect nano-antibacterial components, 12 parts of natural antibacterial components , 5 parts of traditional Chinese medicine antibacterial components; the special-effect nano-antibacterial component is made of silver-loaded nano-titanium dioxide, chlorhexidine acetate-montmorillonite and graphene oxide in a ratio of 2:2:1 by weight; the natural antibacterial component In parts by weight, it includes 2 parts of butterfly fruit extr...

Embodiment 2

[0069] A medical adhesive with high antibacterial performance, comprising the following components in parts by weight:

[0070] 50 parts of poly(isobutyl α-cyanoacrylate-α-octyl cyanoacrylate), 29 parts of high-efficiency antibacterial components, 3 parts of polyurethane, 21 parts of polyisoprene, 3 parts of sodium alginate, 4 parts of lignin 8 parts of tannic acid, 1 part of stabilizer, 1 part of formaldehyde inhibitor, 180 parts of seabuckthorn seed oil, 180 parts of sterile water; high-efficiency antibacterial components include 5 parts of special-effect nano-antibacterial components, 14 parts of natural antibacterial components , 7 parts of traditional Chinese medicine antibacterial components; the special-effect nano-antibacterial component is composed of silver-loaded nano-titanium dioxide, chlorhexidine acetate-montmorillonite and graphene oxide in a ratio of 2:2:1 by weight; the natural antibacterial component In parts by weight, it includes 2 parts of butterfly fruit ...

Embodiment 3

[0073] A medical adhesive with high antibacterial performance, comprising the following components in parts by weight:

[0074] Poly(isobutyl α-cyanoacrylate-α-octyl cyanoacrylate) 53 parts, high-efficiency antibacterial component 32 parts, polyurethane 4 parts, polyisoprene 23 parts, sodium alginate 3 parts, lignin 5 parts 9 parts of tannic acid, 1 part of stabilizer, 1 part of formaldehyde inhibitor, 190 parts of seabuckthorn seed oil, 180 parts of sterile water; high-efficiency antibacterial components include 5 parts of special-effect nano-antibacterial components, 16 parts of natural antibacterial components , 9 parts of traditional Chinese medicine antibacterial components; special-effect nano-antibacterial components are mixed with silver-loaded nano-titanium dioxide, chlorhexidine acetate-montmorillonite and graphene oxide at a weight ratio of 2:2:1; natural antibacterial components In parts by weight, it includes 2 parts of butterfly fruit extract, 2 parts of Aronia n...

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Abstract

The invention relates to a preparation method of a medical adhesive with high antibacterial performance. The method is characterized by comprising the following steps: step one, adding sodium alginate, lignin, tannic acid and a stabilizer into sterile water according to parts by weight, heating to 100 DEG C, stirring and dissolving for 150 minutes, and cooling to room temperature to obtain an aqueous solution A; step two, adding poly(alpha-isobutylcyanoacrylate-alpha-octylcyanoacrylate), polyurethane and polyisoprene into seabuckthorn seed oil according to parts by weight, heating to 80 DEG C,stirring for 75 minutes, and cooling to room temperature to obtain a seabuckthorn seed oil solution B; step three, uniformly mixing the aqueous solution A with the seabuckthorn seed oil solution B, adding highly-effective antimicrobial components and a formaldehyde inhibitor according to parts by weight, and stirring for 4 hours; and step four, filtering, sterilizing, split charging, sealing andpackaging the product obtained in the step three to obtain the medical adhesive with high antibacterial performance.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a medical adhesive with high antibacterial performance and a preparation method thereof. Background technique [0002] With the advancement of medicine, the clinical requirements for the effect of surgical techniques and auxiliary materials are getting higher and higher. The philosophy of modern medicine is to minimize the suffering of patients and to allow patients to recover as quickly as possible. Medical adhesives are a branch of medical polymers. They use biological tissues as bonding objects. Most of the tissues and organs of the human body Adhesive technology can be used to replace partial sutures and ligation operations during the treatment process without anesthesia; it will automatically fall off after the wound is healed. Compared with traditional methods, the use of medical adhesives can effectively shorten the operation time and reduce the pati...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/06A61L24/04A61L24/02A61L24/00
CPCA61L24/0005A61L24/001A61L24/0015A61L24/02A61L24/04A61L24/046A61L24/06A61L24/08A61L2300/102A61L2300/104A61L2300/108A61L2300/206A61L2300/216A61L2300/30C08L5/04C08L47/00C08L75/04C08L33/16C08L97/005
Inventor 林闪光叶善明李程辉应磊
Owner 浙江派菲特新材料科技有限公司
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