Method for preparing polycaprolactone polyol by using enzymatic catalysis method

Abstract

The invention discloses a method for preparing polycaprolactone polyol by using an enzymatic catalysis method. The method comprises: S1, under a solvent condition, carrying out ring opening polymerization by using N-phenyldiethanolamine or binary primary alcohol as an initiator, using caprolactone as a monomer and using immobilized enzyme as catalyst to obtain a prepolymer with a structure represented by a formula V defined in the specification, wherein the sum of n1 and n2 is 1-50; and S2, carrying out a reaction on the prepolymer prepared in the step S1 and D-diethyl tartrate to obtain a compound represented by a formula IV defined in the specification, wherein the sum of n1 and n2 is 1-50. According to the present invention, the product can improve the thermodynamic property and the hydrophilic property of the polycaprolactone material to a certain extent, can introduce a certain amount of hydroxyl groups into the side chain of the polymer, and can be used for post-modification of the polymer or other applications.

Description

Technical field [0001] The invention belongs to the technical field of polyester polyol preparation, and relates to a preparation method of polyester polyol, and specifically relates to a method for preparing polycaprolactone polyol by an enzyme catalysis method. Background technique [0002] Due to the unique biocompatibility, biodegradability, and good permeability of polyvinyl lactone (PCL), it is widely used in the fields of biomaterials and medicine. Polycaprolactone is a semi-crystalline hydrophobic polymer whose crystallinity decreases with increasing molecular weight. Its hydrophobicity leads to a long degradation cycle, which is often difficult to meet the diverse needs of biomedicine. Therefore, the introduction of hydrophilic groups on the polycaprolactone chain can effectively improve this shortcoming, and can also provide potential applications for polymer post-modification. [0003] Polyester polyol materials are usually formed by condensation (or transesterificatio...

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Problems solved by technology

However, the above-mentioned synthesis route of polyester polyol often requires the use of organometallic catalysts or cumbersome procedures such as protection and deprotection of the hydroxyl groups of polyols. These steps are usually accompanied by the disadvantages of polymer metal compound residues and complex synthesis methods.

[0004] In the prior art, the invention patent CN1572851A discloses a method for preparing an enzyme-catalyzed polyester and polyol polymer, but the method uses polyol (polyhydric small molecule) as an initiator to initiate the ring-opening polymerization of lactone or Polycondensation with polybasic acid / anhydride, the hydroxyl group of the obtained polyester polyol is located at the end of the molecular chain, and its number is consistent with the number of hydroxyl groups contained in the initiator (for example: the product obtained by ring opening / polycondensation initiated by diol is polyester binary Alcohol), there is a small number of hydroxyl groups and the inability to control its content, etc.

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