Bioartificial liver system based on human iHep cells and membrane type reactor slab

Abstract

The invention discloses a bioartificial liver system based on human iHep cells and a membrane type reactor slab. The bioartificial liver system comprises a first blood circulating pump, a heparin pump, a plasma separator, a second blood circulating pump and a bioreactor, wherein an inlet of the first blood circulating pump is connected with a blood input pipe, an outlet of the first blood circulating pump is connected with the heparin pump and the plasma separator, and an outlet of the plasma separator is connected with an inlet of the blood input pipe and an inlet of the second blood circulating pump. The bioartificial liver system uses an artificial liver bioreactor with a biological film, accordingly has enough large capacity for containing liver cells capable of maintaining human bodyfunctions. The bioreactor can be put in a conventional cell culture box for liver cell culture, is long in service life and perfect in function, ensures that cultured liver cells do not enter a humanbody blood circulating system and accordingly ensures treatment safety.

Description

technical field [0001] The invention relates to the technical field of biological liver, in particular to a biological artificial liver system based on human iHep cells and a membrane-type plate reactor. Background technique [0002] my country is the country with the most serious liver diseases in the world. Most of the patients are treated through liver transplantation. However, due to the difficulty in obtaining livers, it takes a long time to wait for a liver source, and there is even no chance to get a donor liver. Therefore, most patients have no chance of survival at all. Therefore, an artificial liver system is urgently needed to maintain the patient's life, waiting for the opportunity of liver transplantation, or the opportunity of the recovery of the patient's own liver. [0003] However, due to the high cost of the traditional artificial liver, most patients cannot afford it, the curative effect is very limited, and the mortality rate of liver failure cannot be si...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a bioartificial liver system based on human iHep cells and a membrane-type plate reactor, which is used to solve the problem of monotonous detoxification function, huge plasma consumption, short duration of use, and imperfect functions of the existing artificial liver support system. and safety flaws

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