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Traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage and preparation method thereof

A heart injury and compound preparation technology, which is applied in the field of traditional Chinese medicine monomer compound preparations, can solve the problems of failure to prevent and treat diabetic heart injury, etc., and achieve the effects of convenient application, lowering fasting blood sugar, and easy availability.

Inactive Publication Date: 2018-08-21
NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Background Art There is no traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage

Method used

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  • Traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage and preparation method thereof
  • Traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage and preparation method thereof
  • Traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The invention provides a technical solution: a traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage, including (by mass percentage): 10% of quercetin monomer, 30% of resveratrol monomer and buckwheat rutin monomer Body 60%.

[0022] Quercetin monomer, resveratrol monomer and extracted powdered buckwheat rutin monomer are combined to prepare a compound preparation, and the quercetin monomer, resveratrol monomer and buckwheat rutin monomer are in powder form;

[0023] The traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage is prepared into capsules for the prevention and treatment of diabetic heart damage;

[0024] Buckwheat rutin monomer uses buckwheat flowers and leaves as raw materials, and extracts buckwheat rutin monomer by adding acidic chitosan separating agent extraction method and ethanol extraction method;

[0025] The purity of quercetin monomer is 98...

Embodiment 2

[0031] The invention provides a technical scheme: a traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage, including (by mass percentage): 15% of quercetin monomer, 20% of resveratrol monomer and buckwheat rutin monomer Body 65%.

[0032] Quercetin monomer, resveratrol monomer and extracted powdered buckwheat rutin monomer are combined to prepare a compound preparation, and the quercetin monomer, resveratrol monomer and buckwheat rutin monomer are in powder form;

[0033] The traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage is prepared into capsules for the prevention and treatment of diabetic heart damage;

[0034] Buckwheat rutin monomer uses buckwheat flowers and leaves as raw materials, and extracts buckwheat rutin monomer by adding acidic chitosan separating agent extraction method and ethanol extraction method;

[0035] The purity of quercetin monomer is 98%,...

Embodiment 3

[0041] The invention provides a technical solution: a traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage, including (by mass percentage): 20% of quercetin monomer, 10% of resveratrol monomer and buckwheat rutin monomer Body 70%.

[0042] Quercetin monomer, resveratrol monomer and extracted powdered buckwheat rutin monomer are combined to prepare a compound preparation, and the quercetin monomer, resveratrol monomer and buckwheat rutin monomer are in powder form;

[0043] The traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage is prepared into capsules for the prevention and treatment of diabetic heart damage;

[0044] Buckwheat rutin monomer uses buckwheat flowers and leaves as raw materials, and extracts buckwheat rutin monomer by adding acidic chitosan separating agent extraction method and ethanol extraction method;

[0045] The purity of quercetin monomer is 98...

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Abstract

The invention discloses a traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage. The traditional Chinese medicine monomer compound preparation comprises the following components in percentage by mass: 10-20% of quercetin monomer, 10-30% of resveratrol monomer and 60-70% of buckwheat rutin monomer. The invention further discloses a preparation method of the traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage. The preparation method comprises the following steps: 1, preparing raw materials; 2, extracting the buckwheat rutin monomer; 3, mixing and preparing the preparation. The traditional Chinese medicine monomer compound preparation disclosed by the invention can achieve effects oflowering fasting blood-glucose and heart weight indexes of diabetic rats and improving the cardiac function. The compound preparation has a certain inhibitory effects on protein expression of myocardial damage factor P38 alpha-mitogen activated protein kinase (P38 alpha-MAPK) and protein expression of cardiac microvascular damage factor monocyte chemoattractant protein-1 (MCP-1). Abnornal changesof cardiac muscle and cardiac micro-vessel tissue structures can be obviously improved, and any toxic reaction is not discovered in toxicity test. The compound preparation disclosed by the invention has the characteristics of being high in curative effect, small in dosage, convenient to apply and the like.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine monomer compound preparations, in particular to a traditional Chinese medicine monomer compound preparation for preventing and treating diabetic heart damage and a preparation method thereof. Background technique [0002] At present, the prevention and treatment of diabetic heart damage is mainly based on drugs, and most of them are long-term or even life-long drugs. The long-term application of western medicine oral hypoglycemic drugs or insulin therapy will have problems such as poor compliance, heavy economic burden, and many adverse reactions. In particular, there are no ideal drugs and effective measures to reduce the occurrence of diabetic myocardial and cardiovascular damage. Chinese medicine treatment of this disease has certain advantages, and its effect is mild and lasting. One of the characteristics of traditional Chinese medicine is compound medicine. The use of different ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/05A61K31/7048A61P3/10A61P9/00
CPCA61K31/352A61K31/05A61K31/7048A61P3/10A61P9/00A61K2300/00
Inventor 姜妍王妍关亚丽刘兆莹
Owner NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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