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Small-diameter artificial blood vessel based on freeze casting technology and preparation method thereof

An artificial blood vessel and cryocasting technology, applied in prosthesis, coating, medical science, etc., can solve the problems of long degradation cycle of artificial synthetic materials, unfavorable to autologous angiogenesis, prone to fracture and leakage, etc., to prevent blood Leakage, adhesion promotion, anticoagulant enhancement effect

Active Publication Date: 2018-08-17
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the aspect of replacing small-diameter blood vessels with a diameter of less than 6mm, such as extremity arteries and coronary arteries, there are many serious problems whether it is artificially synthesized polymer materials or natural polymer materials.
Synthetic materials have a long degradation cycle, poor elasticity, and weak endothelialization, which is not conducive to autovascularization
Natural polymer materials have low strength and poor compactness, and blood vessels made of natural polymer materials are prone to fracture and leakage
At the same time, synthetic polymer materials and natural polymer materials are prone to coagulation and form thrombus.

Method used

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  • Small-diameter artificial blood vessel based on freeze casting technology and preparation method thereof
  • Small-diameter artificial blood vessel based on freeze casting technology and preparation method thereof
  • Small-diameter artificial blood vessel based on freeze casting technology and preparation method thereof

Examples

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Effect test

Embodiment 1

[0029] A small-diameter artificial blood vessel based on cryocasting technology, comprising the following steps:

[0030] (1) dissolving the regenerated silk fibroin in water to make a 10% regenerated silk fibroin solution;

[0031] (2) Pour the regenerated silk fibroin solution obtained in step (1) into a mold with a copper base; then insert the copper base of the mold into -196°C liquid nitrogen and freeze for 20 minutes until it is formed;

[0032] (3) Take out the freeze-formed artificial blood vessel from the mold, freeze-dry it under the condition of -50°C and 1pa, and the inner surface of the artificial blood vessel will have a structure; then soak the artificial blood vessel in 1wt% glutaraldehyde solution for cross-linking treatment, The time is 30 minutes; finally, 10wt% synthetic polymer solution (8wt% solution is made by dissolving polycaprolactone in hexafluoroisopropanol) is evenly applied on the outer surface of the artificial blood vessel to obtain a 3mm inner ...

Embodiment 2

[0034] A small-diameter artificial blood vessel based on cryocasting technology, comprising the following steps:

[0035] (1) Carboxymethyl chitosan is dissolved in water to make a 15% carboxymethyl chitosan solution in parts by mass;

[0036] (2) Pour the carboxymethyl chitosan solution obtained in step (1) into a mold with a copper base; then insert the mold into -196°C liquid nitrogen and freeze for 18 minutes until it is formed;

[0037] (3) Take out the freeze-formed artificial blood vessel from the mold, freeze-dry it under the condition of -50°C and 1pa, radial structures appear on the inner surface of the artificial blood vessel; then soak the artificial blood vessel in a glutaraldehyde solution with a mass concentration of 1%. Carry out cross-linking treatment in the middle, the time is 30 minutes; Finally, 10% synthetic polymer solution (formed by dissolving polylactic acid in hexafluoroisopropanol to form a solution with a mass concentration of 10%) is uniformly app...

Embodiment 3

[0039] A small-diameter artificial blood vessel based on cryocasting technology, comprising the following steps:

[0040] (1) Collagen is dissolved in water to make a collagen solution with a mass concentration of 12%;

[0041] (2) Pour the collagen solution obtained in step (1) into a mold with a copper base; then insert the mold into -196°C liquid nitrogen and freeze for 15 minutes until it is formed;

[0042] (3) Take out the freeze-formed artificial blood vessel from the mould, freeze-dry it at -50°C and 1pa, and after freeze-drying, radial structures appear on the inner surface of the artificial blood vessel; then soak the artificial blood vessel in 1% ammonium Carry out cross-linking treatment in the dialdehyde solution, the time is 30 minutes; Finally, 10wt% synthetic polymer solution (formed by dissolving polylactic acid-glycolic acid copolymer in hexafluoroisopropanol) on the outer surface of the artificial blood vessel evenly, i.e. A small-diameter artificial blood ...

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Abstract

The invention belongs to the field of biomedical materials, and particularly relates to a small-diameter artificial blood vessel based on freeze casting technology and a preparation method thereof. The preparation method comprises the following steps: dissolving a natural polymer material in water to prepare a natural polymer solution, pouring the natural polymer solution into a mold, and inserting the mold into liquid nitrogen for freezing forming; and taking a frozen formed artificial blood vessel out of the mold for freezing drying, immersing the artificial blood vessel in a glutaraldehydesolution for cross-linking treatment, and finally evenly coating the surface of the artificial blood vessel with a synthetic polymer solution to obtain the small-diameter artificial blood vessel. Theinner layer of the small-diameter artificial blood vessel is the natural polymer material which has the characteristics of short degradation period and rapid promotion of autologous blood vessel regeneration, and the outer layer of the small-diameter artificial blood vessel is a synthetic polymer material which has certain mechanical properties, and prevents blood leakage; the inner surface of thesmall-diameter artificial blood vessel has a radial structure, and can promote the adhesion of endothelial cells on the surface of the material so as to promote the endothelialization of the artificial blood vessel, and the anticoagulant ability of the artificial blood vessel can be greatly improved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a small-diameter artificial blood vessel based on freezing casting technology and a preparation method thereof. Background technique [0002] With the increasing aging of the global population, cardiovascular diseases are on the rise year by year and have become the number one killer of human health. Severe vascular blockages caused by cardiovascular diseases and arteriosclerosis cannot be cured by vascular stents and drug treatment alone. Some patients have re-stenosis in the stent after surgery, and drugs for the treatment of cardiovascular diseases also have certain risks. The current main treatment is blood vessel transplantation, but the source of autologous blood vessels is extremely limited, and allogeneic or xenogeneic blood vessels have problems such as immune rejection and violation of ethics. Therefore, a large number of artificial blood vessels are urge...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/40A61L27/22A61L27/34A61L27/20A61L27/24A61L27/26
CPCA61L27/20A61L27/222A61L27/227A61L27/24A61L27/26A61L27/34A61L27/50A61L27/507C08L89/00C08L67/04C08L5/08C08L23/06C08L29/04
Inventor 王江林王子豪顾湘查瑶
Owner HUAZHONG UNIV OF SCI & TECH
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