Medical degradable zinc alloy sheet for guiding bone regeneration and preparation method thereof

Abstract

The invention discloses a medical degradable zinc alloy sheet for guiding bone regeneration and a preparation method thereof. According to the technical scheme, zinc alloy is processed, processes of smelting, casting, annealing, extruding, rolling, leveling, punching and the like are carried out to prepare the zinc alloy sheet with the thickness of 0.05 mm to 0.5 mm, the method is used for developing the novel medical degradable zinc alloy sheet for guiding bone regeneration, the barrier film has good biocompatibility, the degradable requirement is met, the mechanical strength being 300 MPa ormore and the capability of maintaining the regeneration space are achieved, and the method can be applied to the field of biomedical degradable barrier films for guiding bone regeneration and all medical application fields based on bone defect repair.

Description

technical field [0001] The invention relates to a medical degradable zinc alloy sheet for guiding bone regeneration and a preparation method thereof, and belongs to the technical field of metal materials, biomedical materials and processing thereof. Background technique [0002] The research and development of medical materials is of great significance to the development of national economy and society. The use of new medical materials can make patients recover and greatly improve the quality of human life. [0003] Zinc and zinc alloys are a class of medical metal materials that have developed rapidly in recent years. They have good biocompatibility and have the function of degrading in biological fluid environments, which can meet the clinical requirements for degradable medical implant materials. Require. The main reason for restricting metal zinc as a degradable medical material for clinical application is that the mechanical properties of pure zinc are poor, and its te...

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Problems solved by technology

The main reason for restricting metal zinc as a degradable medical material for clinical application is that the mechanical properties of pure zinc are poor, and its tensile strength is less than 100Mpa. Clinically, bone tissue engineering implant materials require its mechanical strength to reach more than 200MPa, and its elongation More than 10%, the mechanical properties of pure zinc can not meet the requirements of clinical use

Patent 201510575728.1 "Application of Magnesium Materials as Oral GTR or GBR Membrane Materials" proposes an oral guided bone regeneration membrane material prepared by micro-arc oxidation coating on AZ31 magnesium alloy. The degradation rate of the magnesium alloy guided bone regeneration membrane is too fast , AZ31 magnesium alloy also contains 3% elemental aluminum, which is biologically toxic to the human body, and excessive intake of aluminum can cause dementia, and the mechanical properties of the material are poor, and the possibility of clinical application is low

Patent 201710030803.5 "Preparation method of high-strength, toughness and low-expansion zinc-based wear-resistant alloy sheet" proposes a method of preheating ZA33 zinc-based wear-resistant alloy multiple times to obtain a 0.5mm-3mm zinc alloy sheet. It also contains a large amount of aluminum, and is a wear-resistant alloy used in industry. It does not have the relevant characteristics of biomedical materials, so it cannot be used in medicine

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