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A kind of high-strength silicon calcium phosphate bioceramic material and preparation method thereof

A bioceramic material, silicon calcium phosphate technology, applied in tissue regeneration, prosthesis, medical science, etc., can solve the problems of excellent mechanical properties and biological activity that are difficult to obtain by the preparation method, so as to solve the problem of difficult sintering and improve biological Activity and degradability, the effect of excellent biological performance

Active Publication Date: 2020-07-03
上海积力威尔生物科技合伙企业(有限合伙)
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Calcium silicophosphate, as a newly developed biomaterial, is currently focused on the exploration and research of its preparation method and its biological properties. The previous research work shows that it is difficult to obtain the mechanical properties and biological activity of the current preparation method. excellent material system

Method used

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  • A kind of high-strength silicon calcium phosphate bioceramic material and preparation method thereof
  • A kind of high-strength silicon calcium phosphate bioceramic material and preparation method thereof
  • A kind of high-strength silicon calcium phosphate bioceramic material and preparation method thereof

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preparation example Construction

[0031] The present invention provides a kind of preparation method of high-strength silicon calcium phosphate bioceramic material in the first aspect, described method comprises the following steps:

[0032] (1) uniformly mixing zinc oxide powder, calcium silicon phosphate powder and binder to obtain a mixture, and then molding the mixture to obtain a ceramic green body; and

[0033] (2) Sintering the ceramic green body obtained in step (1) (normal pressure sintering) to prepare a high-strength calcium silicon phosphate bioceramic material.

[0034] In the present invention, the normal pressure sintering process is adopted, which is simple and controllable. Biologically safe and non-toxic zinc oxide is used as the sintering aid, and silicon calcium phosphate is the main phase. Press sintering to prepare high-strength silicon calcium phosphate bioceramic materials; the present invention reduces the sintering temperature by adopting zinc oxide as a sintering aid, and through low...

Embodiment 1

[0052] First weigh 0.5g of hexagonal zinc oxide powder and 49.5g of silicon calcium phosphate powder, add 50g of deionized water, add 5.0g of polyvinyl alcohol aqueous solution with a solution concentration of 10wt%, and planetary ball mill for 3 hours to obtain a uniformly dispersed mixture , and then dried at 60°C for 12 hours, sieved to obtain a mixture with uniform particle size; then the obtained mixture was sequentially subjected to dry pressing (dry pressing molding pressure 50MPa, holding time 5min) and cold isostatic pressing (The pressure of cold isostatic pressing is 200MPa, and the pressure holding time is 5min). The length, width and height are 3×4×40mm. 2°C / min heating rate to 500°C for 2 hours to remove the binder, and then 2°C / min heating rate to 1300°C (final sintering temperature) for 2 hours to obtain a zinc oxide addition of 1wt% High-strength calcium silicon phosphate bioceramic material.

[0053] The high-strength calcium silicophosphate bioceramic mater...

Embodiment 2

[0056] Embodiment 2 is basically the same as Embodiment 1, the difference is:

[0057] The consumption of hexagonal zinc oxide powder is 1.5g, and the consumption of calcium silicon phosphate powder is 48.5g, and the high-strength calcium silicon phosphate bioceramic material that the addition of zinc oxide is obtained is 3wt%; Other difference is as shown in table 1 .

[0058] The cross-sectional morphology of the high-strength calcium silicophosphate bioceramic material prepared in this embodiment is as follows: figure 2 shown. comprehensive figure 2 As can be seen from Table 1, with the increase of zinc oxide addition, the densification degree of the high-strength calcium silicophosphate bioceramic material increases, and the content of zehnite and residual zinc oxide both increase.

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Abstract

The invention relates to a high-strength calcium silicon-phosphate biological ceramic material and a preparation method thereof. The method comprises the following steps: (1) uniformly mixing zinc oxide powder, calcium silicon-phosphate powder and a binding agent to obtain a mixed material; then molding the mixed material to obtain a ceramic blank; (2) sintering the ceramic blank obtained by step(1) to prepare the high-strength calcium silicon-phosphate biological ceramic material. The method provided by the invention has the advantages of simple technology, controllable technology, easinessfor operation, low sintering temperature and the like; the high-strength calcium silicon-phosphate biological ceramic material provided by the invention has the advantages of low porosity (the porosity can be reduced to be about 1 percent), high bending strength (the bending strength can be improved to be 65 to 90MPa), good cell compatibility and the like; the high-strength calcium silicon-phosphate biological ceramic material is especially suitable for being used as a hard tissue repairing material and is a biological and medical material with a great potential; the high-strength calcium silicon-phosphate biological ceramic material can be used as repairing and filling materials of bone tissues and a dental repairing material.

Description

technical field [0001] The invention belongs to the field of bioceramic preparation, and in particular relates to a high-strength silicon calcium phosphate bioceramic material and a preparation method thereof. Background technique [0002] With the extension of human life span, the incidence of fractures caused by trauma, old age or disease is expected to rise to 400% by 2050, followed by huge medical consumption, it is estimated that the annual incidence of The cost of death / mortality will increase by about 8 billion US dollars accordingly, and the handling fee will increase by about 800,000 US dollars. It can be seen that the market potential of bone repair materials in the world is huge. From the perspective of domestic situation, my country is a big country with a population of 1.3 billion and more than 80 million disabled people. According to the report of the Civil Affairs Department, as of 2005, there were more than 15 million patients with limb disorders in my countr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B35/447C04B35/622C04B35/64A61L27/02A61L27/12A61L27/50A61L27/54A61L27/58
CPCA61L27/025A61L27/12A61L27/50A61L27/54A61L27/58A61L2300/412A61L2430/02A61L2430/12C04B35/447C04B35/622C04B35/64C04B2235/3208C04B2235/3284
Inventor 邓繁艳宁聪琴
Owner 上海积力威尔生物科技合伙企业(有限合伙)
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