Medical catheter with copper-containing coating and method for producing the same
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A technology of medical catheter, copper coating
Active Publication Date: 2021-04-30
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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The commonly used treatment method is to bind heparin to the surface of the catheter by coating or ion bonding. Although this method can effectively inhibit the occurrence of coagulation, due to the gradual dissolution of heparin in the blood, its anticoagulant property is gradually lost, and it is only suitable for short-term treatment. anticoagulant
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Embodiment 1
[0040] Preparation of coatings with gradient copper-loaded particles on medical catheters by layer-by-layer chemical grafting:
[0041] Copper-loaded microspheres with active functional groups such as hydroxyl and carboxyl groups were immobilized on natural degradable chitosan polymers with amino and hydroxyl groups by layer-by-layer chemical grafting, and the amount of copper loaded in each layer was gradient. Copper ions are released through layer gradient, and the biofunctionalization of copper-containing coatings can be adjusted.
[0042] (1) Preparation of copper-loaded microspheres
[0043] ① Weigh 0.05g, 0.2g and 0.5g CuCl 2 , and were dissolved in 5mL distilled water to prepare three homogeneous solutions;
[0044] ② Dissolve 1.0 g of PACA in a mixed solution of chloroform and acetone (wherein the volume ratio of chloroform: acetone is 3:2), and prepare a PACA organic solution with a mass volume concentration of 100 mg / mL;
[0045] ③Weigh 1.0g of PVA, dissolve it in d...
Embodiment 2
[0061] Preparation of coatings with gradient copper-loaded microspheres on medical catheters by layer-by-layer electrostatic adsorption method:
[0062] (1) Prepare an aqueous solution of negatively charged sodium hyaluronate (concentration 1-5%), and prepare a hyaluronic acid coating on the inner / outer surface of the medical catheter by leaching;
[0063] (2) Preparation of copper-loaded microspheres
[0064] ①Weigh 0.20g of chitosan into a 250mL single-necked round bottom flask, add 250mL of 2% (mass fraction) acetic acid solution, turn on the electric stirring device and stir slowly until the chitosan is completely dissolved.
[0065] ② Add Span-80 0.4mL and Tween-80 0.6mL while stirring, and continue stirring for 30min to form a uniform, transparent and stable microemulsion. Then add 0.05g copper sulfate powder, stir at high speed to make it spread evenly;
[0066] ③ Then, slowly drop 1mol·L -1 NaOH solution, while stirring at a constant speed, use the PHS-3B precision ...
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Abstract
The invention discloses a medical catheter with a copper-containing coating. The copper-loaded microspheres of different concentrations are fixed / dispersed in the polymer carrier on the surface of the medical catheter in a gradient manner in a certain way, so that the biofunctionalization of the medical catheter can be realized. Among them, the immobilization methods of functionalized copper-loaded microspheres include chemical grafting, physical blending, electrostatic interaction and the like. This kind of medical catheter with biofunctional copper-containing coating can reduce platelet adhesion, anticoagulation, anti-bacterial proliferation and anti-fibrous tissue adhesion after implantation in the body, so as to avoid thrombosis and infection after implantation of medical catheter Or adverse events such as catheter and tissue adhesion.
Description
technical field [0001] The invention relates to the field of implant / interventional catheter medical devices, and in particular provides a copper-coated medical catheter with biological functions that can maintain the circulation of fluid (body fluid, blood, etc.) in the body or maintain the nutritional supply of the human body from the outside. Background technique [0002] Medical catheters are commonly used in fields such as infusion, tumor chemotherapy, total parenteral nutrition, and urine drainage. However, catheter-related infection, related thrombosis, phlebitis, and lumen blockage are relatively common complications of peripheral central venous catheters and other catheters that are embedded in the patient's body for a medium and long term. In clinical practice, once infection and blockage occur, the catheter needs to be discarded and re-intubated, which imposes a great burden on the patient's body. Therefore, reducing the incidence of related complications after c...
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