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Mouthwash and preparation method and application thereof

A technology of mouthwash and purified water, which is applied in dental preparations, oral care, pharmaceutical formulas, etc. It can solve the problems of toothbrush bacteria contamination, poor oral health status, inability to achieve sterilization, anti-inflammatory, and halitosis at the same time, and achieve the number of uses Less, faster to use, less energy consumption

Inactive Publication Date: 2018-08-10
CHENGDU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This also shows that although most people have been able to brush their teeth every day, their oral health is still not ideal
[0004] Although general toothpaste can also reduce the number of pathogenic microorganisms in the oral cavity to a certain extent through its cleaning effect, due to the limitations of toothpaste components in terms of sterilization and halitosis removal, and toothbrushes have serious bacteria-carrying defects, it cannot fundamentally Satisfy people's requirements for thorough oral sterilization, anti-inflammation, deodorization and multi-functional purposes of tooth protection
And present mouthwash usually has the health care effect of cool and refreshing, can not reach the purpose of sterilization, anti-inflammatory, deodorization simultaneously

Method used

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  • Mouthwash and preparation method and application thereof

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Effect test

Embodiment 1

[0023] The preparation of embodiment 1 mouthwash of the present invention

[0024] Purified water 96.35%, pH regulator 1% (v / v), oral care agent 0.2%, flavor enhancer 0.125%, preservative 0.1%, stabilizer 2.1%, solubilizer 0.125%.

[0025] Preparation:

[0026] a. Dilute 1.25ml of peppermint oil dropwise with a small amount of water, add 1.25g of PEG-40 hydrogenated castor oil heated and melted at 50°C, mix until clear, and obtain phase A;

[0027] b. Add 800ml of purified water to phase A, add 1g of tetrasodium edetate, stir to dissolve, add 20g of sodium bicarbonate to dissolve, and obtain phase B;

[0028] c. Add 0.2 g of sodium chlorite and 1 g of sodium benzoate to phase B, dissolve, measure the pH, add about 10 ml of 0.1 mol / l sodium hydroxide solution dropwise, adjust the pH to 9.6-10.3, add purified water to 1000 ml, and filter , that is.

Embodiment 2

[0029] The preparation of embodiment 2 mouthwash of the present invention

[0030] Purified water 96.6%, pH regulator 1% (v / v), oral care agent 0.2%, preservative 0.1%, stabilizer 2.1%.

[0031] Preparation:

[0032] a. Measure 800ml of purified water, add 1g of tetrasodium edetate, stir to dissolve, add 20g of sodium bicarbonate to dissolve, and obtain phase A;

[0033] b. Add 0.2g sodium chlorite and 1g sodium benzoate to phase A, dissolve, measure the pH, add about 15ml of 0.1mol / l sodium hydroxide solution dropwise, adjust the pH to 9.6-10.3, add purified water to 1000ml, filter , that is.

Embodiment 3

[0034] The preparation of embodiment 3 mouthwash of the present invention

[0035] Purified water 96.4%, pH adjuster 1% (v / v), oral care agent 0.2%, flavor enhancer 0.1%, preservative 0.1%, stabilizer 2.1%, solubilizer 0.1%.

[0036] Described preparation method comprises the steps:

[0037] a. Dilute 1ml peppermint oil dropwise with a small amount of water, add 1g of PEG-40 hydrogenated castor oil heated and melted at 50°C, mix until clear, and obtain phase A;

[0038] b. Add 800ml of purified water to phase A, add 1g of tetrasodium edetate, stir to dissolve, add 20g of sodium bicarbonate to dissolve, and obtain phase B;

[0039] c. Add 0.2 g of sodium chlorite and 1 g of sodium benzoate to phase B, dissolve, measure the pH, add about 10 ml of 0.1 mol / l sodium hydroxide solution dropwise to adjust the pH to 9.6-10.3, add purified water to 1000 ml, filter, Instantly.

[0040] The usage method of the antibacterial mouthwash is as follows: 2 times a day, 5-10ml each time, spi...

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Abstract

The invention provides mouthwash and a preparation method and application thereof. The mouthwash is prepared from, 0.2-0.25% of sodium chlorite, 0.5-1% (v / v) of pH conditioning agent, 1.1-2.1 % of stablilzer, 0.1-0.2 % of flavoring agent, 0.1-0.2 % of preservative, 0.1-0.2 % of solubilizer, and the balance purified water. The invention further provides a preparation method and application of the mouthwash. The material combination and component effects better complement one another, and the prepared mouthwash has antibacterial effects on staphylococcus aureus, escherichia coli and candida albicans, thereby relieving discomfort of periodontits, gingivitis, canker sore, dental plaque, gingival bleeding, ozostomia and the like which are caused by pathogenic bacteria, is safe, non-toxic and nonirritating, has no side effects, is a novel cleaning product for oral sterilization and disinfection, and can be applicable to denture soaking and sterilization and disinfection.

Description

technical field [0001] The invention relates to a mouthwash and its preparation method and application. Background technique [0002] With the development of the times, oral health has become one of the important indicators for the World Health Organization to evaluate human health. Most oral diseases and oral problems are mainly caused by pathogenic bacteria in the oral cavity. Therefore, controlling oral pathogens is the main task of preventing oral diseases. [0003] According to epidemiological research results, the prevalence rate of permanent tooth caries among 12-year-old children in my country is 34.5%, which is 7.8 percentage points higher than ten years ago. The caries rate of deciduous teeth of 5-year-old children was 70.9%, an increase of 5.8 percentage points compared with ten years ago. The prevalence of dental caries in children is on the rise. Among the residents aged 35-44, the detection rate of dental calculus in the oral cavity was 96.7%, and the detec...

Claims

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Application Information

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IPC IPC(8): A61K8/02A61K8/20A61K8/19A61K8/44A61K8/92A61K8/368A61Q11/00A61Q17/00A61P1/02A61P31/02A61K6/00
CPCA61K6/52A61K8/02A61K8/19A61K8/20A61K8/368A61K8/44A61K8/922A61P1/02A61P31/02A61Q11/00A61Q17/005
Inventor 许小红陈锐徐丹
Owner CHENGDU MEDICAL COLLEGE
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