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A kind of pet compound medroxyprogesterone acetate composition and application

A technology of medroxyprogesterone acetate and composition, which is applied in the direction of drug combination, medical raw materials derived from ferns/filamentous plants, and pharmaceutical formulas, which can solve the problem that the effective contraceptive rate of pets cannot be fully guaranteed, and the efficacy of Chinese herbal medicines Mild and slow, low bioavailability of Chinese herbal medicines, etc., to reduce the probability of pet poisoning, economical contraceptive efficacy, and enrich the effect of clinical medication

Active Publication Date: 2021-02-02
四川吉星动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at the same time, there are also some limitations. Due to the mild and slow effect of Chinese herbal medicine, the effective contraceptive rate of pets cannot be fully guaranteed, and the bioavailability of Chinese herbal medicine is low, and the treatment cycle is long. Therefore, it is difficult to achieve the ideal treatment method with Chinese herbal medicine alone. contraceptive effect
For example, the patent CN 105434501 A discloses the preparation of the Chinese herbal medicine Quantianchi extract and its application in contraceptives. It has spermicidal effect and has low toxic and side effects, but the contraceptive efficiency needs to be improved after oral administration

Method used

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  • A kind of pet compound medroxyprogesterone acetate composition and application
  • A kind of pet compound medroxyprogesterone acetate composition and application
  • A kind of pet compound medroxyprogesterone acetate composition and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-13

[0049] The prescription (suspension, 1000ml) of an anti-fertility compound medroxyprogesterone acetate composition for pets according to the present invention is shown in Table 1.

[0050] Table 1. Example 1-13 formulations.

[0051]

[0052] Preparation method: Take anhydrous sodium citrate, polyethylene glycol 4000, polysorbate 80, chlorobutanol and water for injection to dissolve in 1000ml, filter, sterilize at 115°C for 30min, and use it as a solvent after cooling. Add prescription amount of medroxyprogesterone acetate, comfrey extract, Example 11-13, and then add Perrin extract, Murata extract or Plantaginaceae extract in the sterile room to prepare suspension, potting in 1ml Available in ampoules.

Embodiment 14

[0053] Example 14: Experimental study on contraception in female mice.

[0054] 1. Experimental design.

[0055] 1.1. Drugs, experimental animal groups and dosing regimens.

[0056] The compound medroxyprogesterone acetate composition preparation is prepared by implementing 2, 5, and 8. Wherein, embodiment 2 contains medroxyprogesterone acetate 18mg / ml, comfrey extract 180mg / ml; embodiment 5 contains medroxyprogesterone acetate 150mg / ml, comfrey extract 100mg / ml; embodiment 8 contains methyl acetate Hydroxyprogesterone 225mg / ml, comfrey extract 15mg / ml; In addition, the single-component comfrey extract (content is 200mg / ml) is prepared with the auxiliary material prescription and preparation method of Example 2, and the auxiliary material prescription and Preparation method Prepare single-component medroxyprogesterone acetate (300mg / ml content), blank suspension (only excipients) and normal saline group.

[0057] Healthy mature Kunming mice, weighing 25-35 g, 840 females an...

Embodiment 15

[0075] Example 15: Research on toxicity of compound medroxyprogesterone acetate to zebrafish.

[0076] 1. Experimental design.

[0077] 1.1. Drugs, experimental animal groups and dosing regimens.

[0078] The compound medroxyprogesterone acetate composition preparation is prepared from implementations 3, 6, and 9. Wherein, embodiment 3 contains medroxyprogesterone acetate 30mg / ml, comfrey extract 150mg / ml; embodiment 6 contains medroxyprogesterone acetate 200mg / ml, comfrey extract 40mg / ml; embodiment 9 contains methyl acetate Hydroxyprogesterone 250mg / ml, comfrey extract 12.5mg / ml; in addition, prepare a single-component comfrey extract (content is 150mg / ml) with the auxiliary material prescription and preparation method of Example 3, and use the auxiliary material prescription of Example 9 And preparation method Prepare single-component medroxyprogesterone acetate (content is 250mg / ml), blank suspension (only containing excipients) and normal saline group.

[0079] Zebrafi...

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Abstract

The invention relates to a compound anti-fertility composition for pets and its application, and belongs to the field of veterinary medicine. The active ingredients of the composition include medroxyprogesterone acetate and Chinese herbal medicine extracts comfrey, and can also contain one or more extracts of other Chinese herbal medicines with anti-fertility effects. According to the parts by mass, the composition contains medroxyprogesterone acetate. Ketone 1‑150,000 parts, Comfrey extract 1‑100,000 parts. The pharmaceutical composition provided by the present invention can be a suspension, which is administered by intramuscular injection, which is convenient and easy to implement. In the present invention, the combination of traditional Chinese and western medicine is used for the first time, and the comfrey extract and medroxyprogesterone acetate are reasonably compatible to form a compound, and the synergistic effect is achieved to achieve multi-target, multi-link and multi-level anti-fertility effects, and can improve effective contraception. It has obvious efficacy, definite curative effect, high safety, simple preparation method, convenient operation, suitable for industrial production, and should be popularized and applied in clinical treatment.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a compound medroxyprogesterone acetate composition preparation for combined treatment with traditional Chinese and western medicine and its application in anti-fertility treatment for pets. Background technique [0002] With the rapid development of China's economy and society, more and more people choose to keep pets to accompany their lives. China has had the habit of keeping cats and dogs since ancient times. According to official reports, the number of pet dogs in China has reached more than 150 million, which is equivalent to one pet dog for every nine Chinese. There are an average of 100,000 dogs in each city, and the number is increasing by 10,000 every year. Nowadays, the problem of overbreeding of pet dogs in domestic cities has become a major concern of the society. According to calculations, if a pair of healthy pet cats mate without any contro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/57A61K36/30A61K36/899A61P15/18A61K35/55A61K33/06
CPCA61K31/57A61K33/06A61K35/55A61K36/07A61K36/12A61K36/15A61K36/16A61K36/185A61K36/232A61K36/234A61K36/236A61K36/28A61K36/30A61K36/31A61K36/45A61K36/47A61K36/62A61K36/65A61K36/68A61K36/71A61K36/736A61K36/75A61K36/756A61K36/758A61K36/804A61K36/81A61K36/88A61K36/896A61K36/899A61K2300/00
Inventor 张凌韩剑锋
Owner 四川吉星动物药业有限公司
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