Lactoferrin vagina expansion suppository and preparation method thereof
A vaginal expansive suppository and lactoferrin technology, applied in peptide/protein components, suppository delivery, pharmaceutical formulations, etc., can solve the problems of metronidazole adverse reactions, metronidazole cancer risk, low biological safety, etc., to promote Effectiveness of the medicine, against the effect caused by Candida albicans
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Embodiment 1
[0054]
[0055]
[0056] Preparation:
[0057] (1) Preparation of drug-containing matrix:
[0058] a) mixing the emulsifier, stabilizer and sustained-release agent in a water bath to obtain an oil phase;
[0059] b) dispersing the mixed solution containing lactoferrin and Bingbo powder as the water phase in the oil phase of step a) to obtain a pre-emulsion;
[0060] c) performing rapid membrane emulsification on the pre-emulsion obtained in step (b), and passing through a microporous membrane with a pore size of 1.5 μm to obtain a drug-containing matrix;
[0061] (2) Pour the drug-containing matrix into a suppository mold, insert an expansion carrier, attach and shape it, and prepare a suppository.
Embodiment 2
[0063]
[0064] The preparation method is the same as in Example 1.
Embodiment 3
[0066]
[0067] The preparation method is the same as in Example 1.
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