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Photocrosslinked thiolated chitosan-polyethylene glycol methacrylate hydrogel used for tissue adhesive, and preparation method thereof

A technology of polyethylene glycol methacrylate and tissue adhesives, which is applied in the fields of surgical adhesives, applications, medical science, etc., can solve problems such as low bonding strength or mechanical strength, and reduce the effectiveness of clinical surgical operations Good mechanical strength, good bonding effect

Inactive Publication Date: 2018-07-24
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these hydrogels tend to swell or dissolve quickly, or have low cohesive or mechanical strength, thus reducing their effectiveness as clinical surgical procedures.

Method used

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  • Photocrosslinked thiolated chitosan-polyethylene glycol methacrylate hydrogel used for tissue adhesive, and preparation method thereof
  • Photocrosslinked thiolated chitosan-polyethylene glycol methacrylate hydrogel used for tissue adhesive, and preparation method thereof
  • Photocrosslinked thiolated chitosan-polyethylene glycol methacrylate hydrogel used for tissue adhesive, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Weigh 0.5 g of chitosan and suspend it in 50 ml of deionized water, add 2.58 mmol of 1-hydroxybenzotriazole, stir at room temperature until a colorless or light yellow transparent solution is formed, then add 5.16 Millimoles of N-acetylcysteine ​​and 10.32 millimoles of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, adjust the pH to 4-5 with concentrated hydrochloric acid, and react at room temperature for 12 hours , dialyzed in ultrapure water for 3 days, and freeze-dried to obtain mercapto-chitosan.

[0028] (2) Dissolve 4 grams of polyethylene glycol in 50 milliliters of toluene, remove the water absorbed by polyethylene glycol by azeotropic evaporation, feed nitrogen and under nitrogen protection, add triethylamine in proportion as acid-binding agent and catalyst , and then slowly drop methacryloyl chloride dissolved in dichloromethane (the concentration of methacryloyl chloride in dichloromethane is 1ml / 10ml), the reaction solution was carried out ...

Embodiment 2

[0031] (1) Weigh 1.0 g of chitosan and suspend it in 100 ml of deionized water, add 5.16 mmol of 1-hydroxybenzotriazole, stir at room temperature until a colorless or light yellow transparent solution is formed, then add 10.32 Millimoles of N-acetylcysteine ​​and 20.64 millimoles of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, adjust the pH to 4-5 with concentrated hydrochloric acid, and react at room temperature for 12 hours , dialyzed in ultrapure water for 3 days, and freeze-dried to obtain mercapto-chitosan.

[0032] (2) Dissolve 4 grams of polyethylene glycol in 50 milliliters of toluene, remove the water absorbed by polyethylene glycol by azeotropic evaporation, feed nitrogen and under nitrogen protection, add triethylamine in proportion as acid-binding agent and catalyst , and then slowly drop methacryloyl chloride dissolved in dichloromethane (the concentration of methacryloyl chloride in dichloromethane is 1ml / 10ml), the reaction solution was carried ou...

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Abstract

The invention relates to a photocrosslinked thiolated chitosan-polyethylene glycol methacrylate hydrogel used for a tissue adhesive, and a preparation method thereof. The hydrogel is obtained throughphotocrosslinking a thiolated chitosan solution and a polyethylene glycol methacrylate solution. The preparation method comprises the following steps: preparation of thiolated chitosan, preparation ofpolyethylene glycol methacrylate, and preparation of the photocrosslinked thiolated chitosan-polyethylene glycol methacrylate hydrogel. The thiolated chitosan and polyethylene glycol methacrylate arerespectively prepared, and the proportions of the two components are adjusted to well control the crosslinking speed, the mechanical strength and the bonding strength of the hydrogel; and the prepared hydrogel has excellent biocompatibility and biodegradability, has excellent cohesiveness to tissues, and is a hydrogel used for the tissue adhesive.

Description

technical field [0001] The invention belongs to the field of hydrogel and its preparation, in particular to a photo-crosslinked mercapto-chitosan-polyethylene glycol methacrylate hydrogel used for tissue adhesives and a preparation method thereof. Background technique [0002] Traditional mechanical wound closure devices used in clinical operations, such as paper clips, rivets, and surgical sutures, often cause damage to the tissues around the wound, requiring a second operation to remove them. For liver, spleen, and kidneys with low cohesion Other organs are not applicable. However, tissue adhesives can effectively solve or avoid these problems. In addition, when tissue adhesives restore the function of damaged parts, they can also restore their appearance before the damage. Therefore, tissue adhesives have become popular in recent years. It has been favored by scientists and researchers all over the world. The currently well-known tissue adhesives are α-acrylate adhesive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/28C08L5/08C08L71/02A61L24/00A61L24/04A61L24/08
CPCA61L24/001A61L24/0031A61L24/043C08J3/075C08J3/28C08J2371/02C08J2405/08C08L71/02C08L5/08
Inventor 莫秀梅曾志文
Owner DONGHUA UNIV
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