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Moringa oleifera leaf extract with lipid lowering activity and extraction method

A technology of Moringa oleifera leaves and extracts, applied in food ingredients containing natural extracts, medical preparations containing active ingredients, food science, etc., can solve problems such as health care products and medicines that have not yet been launched on the market, and achieve stable ingredient content, The effect of high content and blood fat-lowering effect

Inactive Publication Date: 2018-07-20
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are Moringa leaf noodles, Moringa chewable tablets and other Moringa foods on the market, but health care products and medicines related to Moringa leaves have not yet appeared on the market.

Method used

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  • Moringa oleifera leaf extract with lipid lowering activity and extraction method
  • Moringa oleifera leaf extract with lipid lowering activity and extraction method
  • Moringa oleifera leaf extract with lipid lowering activity and extraction method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Pulverization: Weigh 500 g of dried Moringa leaves, and crush the Moringa leaves to 16 mesh.

[0040] (2) Soaking: 4000 mL of 70% ethanol was used to soak the pulverized leaves of Moringa oleifera for 12 hours to obtain a mixture of leaves of Moringa oleifera and ethanol.

[0041] (3) Extraction: put the mixture of Moringa oleifera leaves and ethanol into an extraction tank with a heating temperature of 90° C., conduct heating and reflux extraction for 3 hours, and filter to obtain the first extract. Continue to add 4000 mL of 70% ethanol to the dregs, heat and reflux to extract for 3 hours, filter to obtain the second extract, combine the two extracts, concentrate to 1 L, and obtain the crude extract of Moringa oleifera leaves.

[0042] (4) Purification: Pack HPD-100 macroporous resin column with a column volume of 500 mL. Add water to the crude extract of Moringa oleifera leaves to adjust the concentration of Moringa oleifera leaves to 0.1 g / mL, and adjust the pH...

Embodiment 2

[0048] (1) Pulverization: Weigh 500 g of dried Moringa leaves, and crush the Moringa leaves to 16 mesh.

[0049] (2) Soaking: Soak the pulverized leaves of Moringa oleifera in 3000 mL of 90% ethanol for 12 hours to obtain a mixture of leaves of Moringa oleifera and ethanol.

[0050] (3) Extraction: put the mixture of Moringa oleifera leaves and ethanol into an extraction tank with a heating temperature of 60° C., conduct heating and reflux extraction for 3 hours, and filter to obtain the first extract. Add 3000 mL of 90% ethanol to the medicinal dregs and heat and reflux for extraction for 3 hours, filter to obtain a second extract, combine the two extracts, concentrate to 1 L, and obtain a crude extract of Moringa oleifera leaves.

[0051] (4) Purification: Pack HPD-100 macroporous resin column with a column volume of 500 mL. Add water to the crude extract of Moringa oleifera leaves to adjust the concentration of Moringa oleifera leaves to 0.1 g / mL, and adjust the pH to 3, a...

Embodiment 3

[0055] (1) Pulverization: Weigh 500 g of dried Moringa leaves, and crush the Moringa leaves to 16 mesh.

[0056] (2) Soaking: Soak the pulverized leaves of Moringa oleifera in 6000 mL of 30% ethanol for 12 hours to obtain a mixture of leaves of Moringa oleifera and ethanol.

[0057] (3) Extraction: put the mixture of Moringa oleifera leaves and ethanol into an extraction tank with a heating temperature of 100° C., conduct heating and reflux extraction for 3 hours, and filter to obtain the first extract. Continue to add 6000 mL of 30% ethanol to the dregs, heat and reflux for extraction for 3 hours, filter to obtain the second extract, combine the two extracts, concentrate to 1 L, and obtain the crude extract of Moringa oleifera leaves.

[0058] (4) Purification: Pack HPD-100 macroporous resin column with a column volume of 500 mL. Add water to the crude extract of Moringa oleifera leaves to adjust the concentration of Moringa oleifera leaves to 0.1 g / mL, and adjust the pH to ...

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Abstract

The invention discloses a moringa oleifera leaf extract with lipid lowering activity. The total content of total phenolic acid and total flavonoids reaches 50% or above, the content of isoquercitrin is not lower than 6%, the content of kaempferol-3-glucoside is not lower than 1.5%, the content of vicenin-2 is not lower than 1.5%, the content of chlorogenic acid is not lower than 2%, the content ofisovitex is not lower than 0.15% and the content of vitexin is not lower than 0.15%. The invention further discloses an extraction method of the moringa oleifera leaf extract. The moringa oleifera leaf extract prepared through the method is relatively high in extraction rate and stable in component content.

Description

technical field [0001] The invention relates to a moringa leaf extract, in particular to a moringa leaf extract with lipid-lowering activity, and also relates to a method for extracting the moringa leaf extract. Background technique [0002] Moringa belongs to the family Moringa and the genus Moringa, which originated in the sub-Himalayas of India. It is a natural food containing complete nutrients. The roots, stems, leaves and seeds of Moringa are rich in nutrients, and the leaves have the highest content of active ingredients. Moringa is also rich in various medicinal components, including polyphenolic compounds such as phenolic acids and flavonoids, and other trace elements. India and African countries are often used to treat diabetes, hypertension, cardiovascular disease, obesity and other diseases. Moringa has been introduced and cultivated in my country's Guangdong, Yunnan, Hainan and Sichuan. In 2012, Moringa was approved by the Ministry of Health of China as a new...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P3/06A23L33/105
CPCA23L33/105A23V2002/00A61K36/185A61K2236/33A61K2236/55A23V2200/3262A23V2250/21
Inventor 张蜀邓红曾明莹黄德浩
Owner GUANGDONG PHARMA UNIV
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