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Bone tuberculosis medicine controlled-release microsphere with bone repairing function and preparation method

A technology for drug controlled release and bone tuberculosis, which is applied in the directions of medical preparations, pharmaceutical formulations, and drug combinations containing active ingredients, can solve the problem of multiple antibacterial drugs being loaded on the same carrier, etc., and achieves application potential and great value. Biocompatible, highly targeted effects

Inactive Publication Date: 2018-07-20
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is rare to see multiple antibacterial drugs loaded on the same carrier, and there is no report on the simultaneous loading of osteoinductive growth factors and multiple tuberculosis drugs on a carrier to achieve asynchronous and controlled release

Method used

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  • Bone tuberculosis medicine controlled-release microsphere with bone repairing function and preparation method
  • Bone tuberculosis medicine controlled-release microsphere with bone repairing function and preparation method
  • Bone tuberculosis medicine controlled-release microsphere with bone repairing function and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Preparation of Novel Bone Tuberculosis Drug Controlled Release Microspheres with Bone Repair Function

[0043]Weigh 0.0381g of collagen and 0.0019g of bone morphogenic protein (BMP) and dissolve them in 200mL of phosphate buffered saline to obtain solution I; weigh 0.8g of zinc acetate and 0.2g of calcium acetate and dissolve them in 10mL of deionized water to obtain solution II; Add solution I to the Erlenmeyer flask, add solution II to it under agitation, react at room temperature for 3 hours, centrifuge, wash with water, freeze-dry to obtain the hybrid skeleton; weigh 0.2g polylactic acid, 0.01g rifampicin and 0.1g Dissolve and disperse the hybrid skeleton into 10mL of dichloromethane to obtain solution III; prepare 100mL of sodium dodecylsulfonate aqueous solution with a concentration of 1.5g / L, add it to a three-necked flask, add solution III to it under mechanical stirring, and store at room temperature Volatilize for 5 hours, centrifuge, wash with wate...

Embodiment 2

[0044] Example 2: Preparation of Novel Bone Tuberculosis Drug Controlled Release Microspheres with Bone Repair Function

[0045] Weigh 0.0952g human serum albumin and 0.0048g bone growth peptide (OGP) and dissolve in 200mL phosphate buffered saline solution to obtain solution I; weigh 1.12g zinc nitrate and 0.28g calcium chloride and dissolve in 10mL deionized water to obtain Solution II; add solution I to the Erlenmeyer flask, add solution II to it under stirring condition, react at room temperature for 2 hours, then centrifuge, wash with water, and freeze-dry to obtain the hybrid skeleton; weigh 0.1g polylactic acid, 0.015g rifampic acid Dissolve and disperse 0.05g of the hybrid skeleton in 5mL of dichloromethane to obtain solution III; prepare 100mL of sodium dodecylsulfonate aqueous solution with a concentration of 1.5g / L, add it to a three-necked flask, and add the solution to it under mechanical stirring III, volatilized at room temperature for 6 hours, centrifuged, wash...

Embodiment 3

[0046] Example 3: Preparation of Novel Bone Tuberculosis Drug Controlled Release Microspheres with Bone Repair Function

[0047] Weigh 0.0571g lysine and 0.0029g transforming growth factor family (TGFs) and dissolve in 200mL phosphate buffer solution to obtain solution I. ; Weigh 1.5g of zinc chloride and 0.3g of calcium gluconate and dissolve them in 15mL of deionized water to obtain solution II; add solution I to the Erlenmeyer flask, add solution II to it under stirring conditions, react at room temperature for 1 hour, and centrifuge , washed with water, and freeze-dried to obtain the hybrid skeleton; weigh 0.21g of polylactic acid, 0.014g of rifampicin and 0.105g of the hybrid skeleton to dissolve and disperse them in 7mL of dichloromethane to obtain solution III; configure the concentration of 1.5g / L Add 100 mL of sodium dodecylsulfonate aqueous solution into a three-necked flask, add solution III to it under mechanical stirring, volatilize at room temperature for 8 hours...

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Abstract

The invention relates to a bone tuberculosis medicine controlled-release microsphere with a bone repairing function and a preparation method. According to structural design, an active component for inducing bone growth is put into the microsphere, a hydrophobic drug, namely rifampicin, which takes functions into play in a later bacterium inhibition period, is supported by a middle polylactic acidlayer, a hydrophilic antituberculosis drug, namely isoniazide, is coated by chitosan and is arranged in an outer layer, and sequential layer-by-layer release of the three components can be achieved. After step-by-step bacterium inhibition of the medicines, the active component for inducing bone growth is released, then bone repairing can be achieved, and bone tuberculosis can be treated comprehensively. Carrier components are also finely selected, phosphorus, calcium, collagen and the like are all essential substances for osteogenesis, and the chitosan and the polylactic acid are good in biocompatibility and can be degraded and absorbed at focuses. Therefore, the controlled-release microsphere has very good specificity, is capable of providing an efficient novel material to clinical treatment on bone tuberculosis, and has great application potential and values.

Description

technical field [0001] The invention belongs to the field of new material synthesis, and relates to bone tuberculosis drug controlled-release microspheres with bone repair function and a preparation method. Background technique [0002] Bone tuberculosis is a common extrapulmonary tuberculosis, accounting for about 3% to 5% of the total incidence of tuberculosis. In order to solve this medical problem, local slow-release drug administration, extended debridement and "lesion clearance + slow-release antibacterial" etc. Therapies have been proposed and applied clinically one after another. The above-mentioned treatment plan plays a positive role in the treatment of bone tuberculosis to a certain extent, but the treatment of bone tuberculosis will cause local bone defects. The growth of residual tuberculosis makes tuberculosis reciprocating. [0003] Chemotherapy with anti-tuberculosis drugs often requires long-term systemic administration. Commonly used anti-tuberculosis dru...

Claims

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Application Information

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IPC IPC(8): A61K9/62A61K9/58A61K47/34A61K47/36A61K47/02A61K31/4409A61K31/496A61K38/18A61K38/30A61K38/39A61K38/38A61K31/198A61K31/405A61P19/08A61P31/06
CPCA61K9/5031A61K9/5036A61K9/5073A61K31/198A61K31/405A61K31/4409A61K31/496A61K38/1825A61K38/1841A61K38/1858A61K38/1866A61K38/1875A61K38/30A61K38/385A61K38/39A61K47/02A61K2300/00
Inventor 张宝亮王继启张秋禹张和鹏呼延钰
Owner NORTHWESTERN POLYTECHNICAL UNIV
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