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Preparation method of drug-loaded wound dressing

A wound dressing and drug-loading technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of secondary injury, wound exudate cannot be absorbed, and slow down the scab rate

Inactive Publication Date: 2018-07-17
HUNAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the shortcomings of traditional wound dressings are also very obvious: easy to cause infection; wound exudate cannot be absorbed, slowing down the rate of scabbing; dressings are easy to adhere to the wound, and it is easy to cause secondary damage during dressing changes
Therefore, traditional wound dressings are gradually unable to meet clinical requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 18 kg of non-ionic polyurethane hydrogel particles, 25 kg of thermoplastic polyurethane particles with a Shore hardness of 50A, and 120 kg of N,N-dimethylformamide in a reactor, heat to 50°C and stir Completely dissolve the polyurethane hydrogel particles and thermoplastic polyurethane particles, and obtain a polyurethane solution after cooling; add 40 kg of 500-mesh Yunnan Baiyao powder, and stir evenly with a high-speed mixer to obtain a solid-liquid mixture; carry out 0.5h decompression and defoaming treatment Then quickly apply the solid-liquid mixture on the release paper, then immerse the release paper in deionized water, put it in a drying oven after solidification and form a film, and dry it at 50°C for 1 hour, and remove the release paper after cooling, that is The solid-loaded Yunnan Baiyao film was obtained; the solid-loaded Yunnan Baiyao film was immersed in the extract of Zizhucao (the content of Zizhucao extract was 5.0%) for 3 hours, and then vacuum ...

Embodiment 2

[0024] Weigh 10 kg of non-ionic polyurethane hydrogel particles, 42 kg of thermoplastic polyurethane particles with a Shore hardness of 50A, and 120 kg of N,N-dimethylformamide in a reactor, heat to 60°C and stir Completely dissolve the polyurethane hydrogel particles and thermoplastic polyurethane particles, and obtain a polyurethane solution after cooling; add 40 kg of 1000-mesh Yunnan Baiyao powder, and stir evenly with a high-speed stirrer to obtain a solid-liquid mixture; carry out 0.5h decompression and defoaming treatment Then quickly apply the solid-liquid mixture on the release paper, then immerse the release paper in deionized water, place it in a drying oven after solidification and form a film, and dry it at 50°C for 2 hours, and remove the release paper after cooling, that is The solid-loaded Yunnan Baiyao film was obtained; the solid-loaded Yunnan Baiyao film was immersed in the extract of Zizhucao (the content of Zizhucao extract was 10.0%) for 3 hours, and then ...

Embodiment 3

[0027] Weigh 10 kg of non-ionic polyurethane hydrogel particles, 25 kg of thermoplastic polyurethane particles with a Shore hardness of 60A, and 120 kg of N,N-dimethylacetamide in a reactor, heat to 70°C and stir Completely dissolve the polyurethane hydrogel particles and thermoplastic polyurethane particles, and obtain a polyurethane solution after cooling; add 40 kg of 1500-mesh Yunnan Baiyao powder, and stir evenly with a high-speed mixer to obtain a solid-liquid mixture; carry out 0.5h decompression and defoaming treatment Afterwards, quickly apply the solid-liquid mixture on the release paper, then immerse the release paper in deionized water, place it in a drying oven after solidification and form a film, and dry it at 50°C for 1 hour, and remove the release paper after cooling to obtain Solid-loaded Yunnan Baiyao film; soak the solid-loaded Yunnan Baiyao film in the extract of Zizhucao (the content of Zizhucao extract is 6.0%) for 3 hours, and then vacuum freeze-dry to o...

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Abstract

The invention discloses a preparation method of a drug-loaded wound dressing. The method mainly comprises the following steps: adding polyurethane hydrogel particles, thermoplastic polyurethane particles and a solvent into a reactor, heating and stirring to fully dissolve the polyurethane hydrogel particles and the thermoplastic polyurethane particles in the solvent, and cooling to obtain a polyurethane solution; adding Yunnan Baiyao powder, stirring evenly to obtain a solid-liquid mixture, and defoaming under reduced pressure; uniformly applying the solid-liquid mixture to release paper, andimmersing the release paper in deionized water; after the solid-liquid mixture is completely cured for formation of a film, placing the film in a dry box at 50 DEG C; after cooling, removing the release paper to obtain a Yunnan Baiyao-immobilizing film; soaking the Yunnan Baiyao-immobilizing film in Callicarpa macrophylla Vahl extract for 3 hours, and freeze-drying under vacuum to obtain a double-drug-loading film; according to the actual application requirements, cutting the double-drug-loading film into an appropriate size, and pasting the cut double-drug-loading film onto medical non-wovengauze to obtain the product. The raw materials of the drug-loaded wound dressing are easy to obtain, the equipment is simple, and the product can stop bleeding, disperse blood stasis, relieve swellingand relieve pain, and has the effect of antisepsis and anti-inflammation.

Description

technical field [0001] The invention belongs to the technical field of organic composite materials, and in particular relates to a preparation method of a drug-loaded wound dressing. Background technique [0002] Wound dressing is a medical product that wraps a wound, which protects the wound by covering it and promotes wound healing. Traditional wound dressings are mainly gauze, absorbent cotton and synthetic fibers. At the same time, the shortcomings of traditional wound dressings are also very obvious: easy to cause infection; wound exudate cannot be absorbed, slowing down the scab rate; dressings are easy to adhere to the wound, and it is easy to cause secondary injuries during dressing changes. Therefore, traditional wound dressings are gradually unable to meet clinical requirements. New wound dressings not only need to protect the wound, but also need to be able to absorb wound exudate, keep the wound moist, prevent wound infection, stop bleeding and reduce inflammat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/44A61L15/40
CPCA61L15/26A61L15/40A61L15/44A61L2300/30A61L2300/404A61L2300/418A61L2300/45C08L75/04
Inventor 李筱芳熊一帜周虎王晓虹眭玉光汤龙
Owner HUNAN UNIV OF SCI & TECH
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