P/m-fluorotoluene mechanical apparatus

Abstract

The invention discloses a P / m-fluorotoluene mechanical apparatus. The P / m-fluorotoluene mechanical apparatus comprises a condensation point control cabin, wherein the inner wall of the condensation point control cabin is provided with a heat insulation layer, a first reaction kettle is installed inside the condensation point control cabin, the upper end of the first reaction kettle penetrates through the condensation point control cabin and extends to a position above the condensation point control cabin. The first reaction kettle is arranged in the condensation point control cabin, the ice salt bath cooling is performed for the diazotization so as to control the heat stability after the reaction of a diazo compound; the heat insulation layer is arranged on the inner wall of the condensation point control cabin, the heat exchange between air and air in the condensation point control cabin can be well insulated; and a control amount adjusting apparatus is arranged below a sodium nitritebox body, the addition amount of the sodium nitrite can be controlled by virtue of a pressure sensor and scales on a delivery tank, and the sodium nitrite is uniformly added into the first reaction kettle by virtue of a uniform distribution pipe, so that the accuracy of a reactant ratio can be improved.

Description

technical field [0001] The invention relates to the technical field of production equipment for m-fluorotoluene, in particular to a mechanical device for m-fluorotoluene. Background technique [0002] p-Fluorotoluene is an important intermediate in the pharmaceutical industry. It is widely used in the fields of medicine, pesticides, dyes and fluoroplastics. It can be used to synthesize new antibiotic quinolones, synthesize antihypertensive drugs, and synthesize some anti-inflammatory drugs. It is an important intermediate for the synthesis of the powerful sleeping agent fluazepam. The existing p-fluorotoluene has poor thermal stability due to the formation of diazides during the production process. Most of the diazotization reactions need to be carried out at low temperatures. The existing cooling The structure of the device is simple, and the temperature cannot be lowered to a very low level, and the heat exchange between the device and the outside is serious, and the tempe...

AI Technical Summary

Problems solved by technology

[0002] p-Fluorotoluene is an important intermediate in the pharmaceutical industry. It is widely used in the fields of medicine, pesticides, dyes and fluoroplastics. It can be used to synthesize new antibiotic quinolones, synthesize antihypertensive drugs, and synthesize some anti-inflammatory drugs. It is an important intermediate for the synthesis of the powerful sleeping agent fluazepam. The existing p-fluorotoluene has poor thermal stability due to the formation of diazides during the production process. Most of the diazotization reactions need to be carried out at low temperatures. The existing cooling The structure of the device is simple, the temperature cannot be lowered to a very low level, and the heat exchange between the device and the outside is serious, and the temperature cannot be well isolated, so that the intermediate product of p-m-fluorotoluene cannot be completely generated. At the same time, it is necessary to add sub The addition of sodium nitrate and sodium nitrite and the uniformity of addition will also affect the production quality of p-fluorotoluene, and there will be more impurities in p-fluorotoluene after production, which needs to be purified. Therefore , the present invention proposes a p-fluorotoluene mechanical device to solve the problems existing in the prior art

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