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Curcuma oil inclusion compound for preventing or treating acute liver failure and preparation method thereof

A technology of acute liver failure and zedoary oil, applied in the field of preparation of zedoary oil inclusion compound, can solve the problems of restricting the development of zedoary oil inclusion compound, low encapsulation rate, oil leakage of zedoary oil, etc.

Active Publication Date: 2021-11-09
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are two problems in the inclusion method of zedoary oil at present: low encapsulation efficiency and oil leakage of zedoary oil, which limit the further development of zedoary oil inclusion complexes

Method used

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  • Curcuma oil inclusion compound for preventing or treating acute liver failure and preparation method thereof
  • Curcuma oil inclusion compound for preventing or treating acute liver failure and preparation method thereof
  • Curcuma oil inclusion compound for preventing or treating acute liver failure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Extraction and inclusion experiment of zedoary oil

[0039] Extraction process of zedoary oil

[0040] Put 222.00kg of curcuma coarse powder into 3m 3 In the extraction tank, add drinking water 10 times the amount of medicinal materials, soak for 12 hours, open the condensate valve and the steam valve at the bottom of the extraction tank, and at the same time open the valve connecting the extraction tank and the volatile oil extractor, heat to boiling, and observe the steam at any time during the decoction process Pressure gauge, temperature gauge, and storage tank pressure gauge values, and record the boiling time and temperature. The steam pressure is controlled at 0.15-0.2Mpa, the temperature is controlled at about 100°C, the steam valve is controlled, the distillation is extracted continuously for 7 hours, and the distillation situation is constantly observed from the sight glass. During the distillation and extraction process, the distillate is collected in the...

Embodiment 2

[0054] Pharmacological Activity Experiment of Curcuma Oil Inclusion Compound

[0055] The preventive / therapeutic effect of zedoary oil inclusion compound on acute liver failure has been confirmed in animal experiments by the following methods.

[0056] 1. Materials and methods

[0057] 1. Reagents

[0058] D-galactosamine, purchased from SIGMA (Lot#WXBC1587Vp code: 101670397, CAS 1772-03-08). LPS, purchased from SIGMA Corporation (Lot #044M4004V). Universal tissue fixative (neutral), purchased from Wuhan Google Biotechnology Co., Ltd., Lot 160201. GOT kit (microplate reader method) and GPT kit (microplate reader method) were purchased from Nanjing Jiancheng Bioengineering Institute. ELISA kit was purchased from Shanghai Yikesai Biological Products Co., Ltd., batch number: 21F091. PBS, purchased from Zhongke Maichen (Beijing) Technology Co., Ltd. (Lot: F31HU030). Hematoxylin-eosin staining solution was purchased from Wuhan Google Biotechnology Co., Ltd. (Product No.: G1...

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Abstract

The present application relates to a preparation method of a curcuma oil clathrate that can be used for preventing or treating acute liver failure, the obtained curcuma oil clathrate and a pharmaceutical composition containing the same. The curcuma oil inclusion compound and pharmaceutical composition of the present application have obvious therapeutic effects on acute liver failure such as reducing mortality, reducing transaminase, inhibiting liver cell apoptosis and necrosis, and inhibiting immune inflammation damage.

Description

technical field [0001] The present application relates to a preparation method of zedoary oil inclusion compound, the obtained zedoary oil inclusion compound and a pharmaceutical composition containing the same. Specifically, the present application relates to a preparation method of a curcuma oil inclusion compound for preventing or treating acute liver failure, the obtained curcuma oil inclusion compound and a pharmaceutical composition containing the same. Background technique [0002] Acute liver failure (ALF) is severe damage to liver cells caused by multiple factors, resulting in dysfunction of liver organ synthesis, metabolism, transport and excretion, and is one of the clinically harmful diseases. Debilitating symptoms such as jaundice, coagulopathy, hepatic encephalopathy. The result of acute liver failure is rapid development into multiple organ failure, and finally death may occur due to multiple organ failure, and the mortality rate is very high. , rapid develo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K36/9066A61K47/61A61P1/16
CPCA61K36/9066A61K2236/331A61K2236/51A61K2236/53
Inventor 肖小河柏兆方崔鹤蓉韩晶晶王伽伯闫敬武杜成德邸春盛
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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