Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of compound zinc gluconate and ibuprofen granules

A granule and zinc cloth technology, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of acute toxicity hazards, low work efficiency, environmental pollution, etc. Acute toxicity hazards and serious environmental pollution, improving work efficiency and reducing energy consumption

Active Publication Date: 2015-04-01
BEIJING SHOUER PHARMA FACTORY
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether it is a saturated solution method or a grinding method, it is necessary to spray-dry the clathrate suspension first, and then perform granulation operation, and this process requires high energy consumption, long time and low work efficiency
Not only that, choose organic solvents such as cyanide, which is moderately toxic, causing acute toxic hazards to personnel and causing serious pollution to the environment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of compound zinc gluconate and ibuprofen granules
  • Preparation method of compound zinc gluconate and ibuprofen granules
  • Preparation method of compound zinc gluconate and ibuprofen granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Add 2 times the volume of 95% (volume concentration) ethanol to 4.50kg of ibuprofen, and heat it in a water bath below 70°C until the ibuprofen is completely dissolved. During this process, no crumbs of ibuprofen float on the surface of the solution No oil drop ibuprofen coverage;

[0042] (2) Add 1 times the volume of purified water to 24.75kg of β-cyclodextrin to disperse, and stir well until it becomes a slurry;

[0043] (3) Use a homogenizer or a colloid mill to stir the β-cyclodextrin slurry, while stirring, slowly add the ibuprofen alcohol solution to the β-cyclodextrin slurry at a uniform speed, and continue stirring for 1 hour after adding to obtain inclusion material suspension, put it aside;

[0044] (4) Grind sucrose, pass through 80-mesh sieve, and set aside; mix 3.00kg of zinc gluconate, 0.06kg of chlorpheniramine maleate, 0.45kg of sodium carboxymethyl cellulose, and 56.34kg of sucrose evenly , transferred to the pot of the spray granulator, put the ...

Embodiment 2

[0049] (1) Add 2.5 times the volume of 95% (volume concentration) ethanol to 4.50kg ibuprofen, and heat it in a water bath below 70°C until the ibuprofen is completely dissolved. During this process, there is no floating ibuprofen debris on the surface of the solution No oil drop ibuprofen coverage;

[0050] (2) Add 1.5 times the volume of purified water to 24.75kg of β-cyclodextrin to disperse, and stir well until it becomes a slurry;

[0051] (3) Use a homogenizer or a colloid mill to stir the β-cyclodextrin slurry, and slowly add the ibuprofen alcohol solution to the β-cyclodextrin slurry at a uniform speed while stirring, and continue stirring for 1 hour after adding to obtain inclusion material suspension, put it aside;

[0052] (4) Grind sucrose, pass through 80-mesh sieve, and set aside; mix 3.00kg of zinc gluconate, 0.06kg of chlorpheniramine maleate, 0.45kg of sodium carboxymethylcellulose, and 56.34kg of sucrose evenly , transferred to the pot of the spray granulat...

Embodiment 3

[0057] (1) Add 3 times the volume of 95% (volume concentration) ethanol to 4.50kg ibuprofen, and heat it in a water bath below 70°C until the ibuprofen is completely dissolved. During this process, there is no floating ibuprofen debris on the surface of the solution No oil drop ibuprofen coverage;

[0058] (2) Add 2.5 times the volume of purified water to 24.75kg of β-cyclodextrin to disperse, and stir until it becomes a slurry;

[0059] (3) Use a homogenizer or a colloid mill to stir the β-cyclodextrin slurry, while stirring, slowly add the ibuprofen alcohol solution to the β-cyclodextrin slurry at a uniform speed, and continue stirring for 1 hour after adding to obtain inclusion material suspension, put it aside;

[0060] (4) Grind sucrose, pass through 80-mesh sieve, and set aside; mix 3.00kg of zinc gluconate, 0.06kg of chlorpheniramine maleate, 0.45kg of sodium carboxymethyl cellulose, and 56.34kg of sucrose evenly , transferred to the pot of the spray granulator, put the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of compound zinc gluconate and ibuprofen granules. The preparation method is characterized by comprising the following steps: adding ethanol with volume concentration being greater than or equal to 80 percent into ibuprofen; heating in water bath or increasing the using amount of the ethanol without performing water bath; dispersing beta-cyclodextrin by using purified water; mixing the beta-cyclodextrin and the ibuprofen to obtain inclusion suspension; mixing zinc gluconate, chlorpheniramine maleate, sodium carboxymethylcellulose and sugar, spraying to the inclusion suspension, granulating and drying; crushing granules and performing secondary granulation by using a 20-mesh screen; mixing solid flavoring orange essence. The preparation method has the beneficial effects that the ibuprofen is dissolved by using ethanol with volume concentration being greater than or equal to 80 percent to guarantee more sufficient inclusion, the beta-cyclodextrin and the ibuprofen are subjected to grinding and inclusion, so that the inclusion effect of the beta-cyclodextrin is achieved, the peculiar smell of the ibuprofen is covered and the dissolvability of the product is effectively improved, the inclusion is directly used as an adhesive to perform spraying and granulation, the operation is simplified, the working efficiency is improved and meanwhile the energy consumption is reduced.

Description

technical field [0001] The invention relates to a method for preparing western medicine granules compound zinc cloth granules, belonging to the technical field of granules preparation. Background technique [0002] The prescription of compound zinc cloth granules is as follows (statutory standard WS1-X-092-95Z): [0003] [0004] Among them, ibuprofen has a slightly specific odor, is almost insoluble in water, and has a melting point of 74.5-77.5°C. Ibuprofen is insoluble in water and floats on the surface of the solution in the form of crumbs. If the water temperature is too high, it will melt and cover the surface of the solution in the form of oil droplets, and condense in the form of lumps on the surface of the solution after cooling. Therefore, there are following deficiencies in the above-mentioned prescription of legal standards and its technological process: [0005] 1. Properties: the requirement in the quality standard is sweet taste; the specific smell of ibu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4402A61K47/48A61K9/16A61P31/16A61K31/192A61K31/191A61K47/69
Inventor 刘春赵树霞
Owner BEIJING SHOUER PHARMA FACTORY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com