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Multifunctional titanium implant based on polydopamine modification and preparation method of multifunctional titanium implant

A technology of polydopamine and titanium implants, which is applied in prosthesis, pharmaceutical formulations, coatings, etc., can solve the problem of low bonding strength between coatings and titanium metal substrates, lack of multi-species antibacterial properties of antibacterial factors, and affect the successful application of implants And other problems, to achieve high-efficiency antibacterial effect, improve stability, improve the effect of sealing performance

Inactive Publication Date: 2018-06-22
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing dental implants are mainly composed of a titanium metal base and a coating covering the surface of the titanium metal base, but the bonding strength between the coating and the titanium metal base is low and the antibacterial factors in the coating lack multi-species antibacterial properties. Therefore, it is difficult to inhibit the reproduction of S.sanguinis, P.gingivalis, F.nucleatum and other bacteria that cause dental peri-implantitis, which affects the successful application of implants

Method used

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  • Multifunctional titanium implant based on polydopamine modification and preparation method of multifunctional titanium implant
  • Multifunctional titanium implant based on polydopamine modification and preparation method of multifunctional titanium implant
  • Multifunctional titanium implant based on polydopamine modification and preparation method of multifunctional titanium implant

Examples

Experimental program
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Effect test

Embodiment 1

[0032] In this embodiment, the preparation method steps of polydopamine-based multifunctional titanium dental implant are as follows:

[0033] (1) Polish the titanium metal surface with 280, 320, 400, 600, 800, 1000 and 1200 mesh metallographic sandpaper in turn to make a mirror surface, and then place it in deionized water, acetone, ethanol and deionized water respectively for ultrasonic Clean for 30 minutes. After ultrasonic cleaning, soak it in NaOH solution with a concentration of 5mol / L, heat it to 60°C and place it for 24 hours. After the time is up, remove the NaOH solution, then wash it with deionized water until it is neutral, and then soak it In deionized water, heat to 40°C and place for 24h. After the time is up, remove the deionized water, dry it at 40°C for 24h, then put it into the muffle furnace, and heat the furnace at a heating rate of 5°C / min. Raise the temperature to 600°C and hold it for 1 hour. After the holding time is up, stop the heating of the muffle ...

Embodiment 2

[0039] The difference between the preparation method of the polydopamine-modified multifunctional titanium dental implant described in this example and Example 1 is that the mixed deposition solution is prepared according to the components and contents in Table 2. The resulting multifunctional titanium dental implant marks are shown in Table 2.

[0040] Table 2

[0041]

Embodiment 3

[0043] The difference between the preparation method of polydopamine-modified multifunctional titanium dental implant described in this example and Example 1 is that the mixed deposition solution is prepared according to the components and contents in Table 3. The resulting multifunctional titanium dental implant marks are shown in Table 3.

[0044] table 3

[0045]

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Abstract

The invention provides a multifunctional titanium implant based on polydopamine modification and a preparation method of the multifunctional titanium implant. The multifunctional titanium implant is prepared as follows: a silane coupling agent is added to the surface of pre-activated titanium metal and subjected to an auto-polymerization reaction with polydopamine, functional groups are grafted onthe surface of a polydopamine coating obtained through the auto-polymerization reaction, and finally, the multifunctional titanium implant is obtained, wherein the bonding strength between the polydopamine coating and the surface of the titanium metal is 4.5-6.5 MPa. The multifunctional titanium implant adopts a porous surface structure, has good cell biocompatibility, has an efficient antibacterial effect on peri-implantitis specific bacteria and particularly has a significant synergistic antibacterial effect on multiple strains. The preparation method of the multifunctional titanium implanthas the characteristics of being simple in process and suitable for promotion.

Description

technical field [0001] The invention belongs to the field of biological materials, and relates to a polydopamine-based multifunctional titanium implant and a preparation method thereof. Background technique [0002] At present, the clinical failure of dental implants is often due to the inability to form a dense bond between the soft tissue around the implant and the implant material and bacterial infection, which leads to the failure of the implant. Therefore, the combination ability of implants and soft tissues and antibacterial properties (especially multi-strain antibacterial properties) are crucial to the successful application of implants. [0003] Existing dental implants are mainly composed of a titanium metal base and a coating covering the surface of the titanium metal base, but the bonding strength between the coating and the titanium metal base is low and the antibacterial factors in the coating lack multi-species antibacterial properties. Therefore, it is diffi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/34A61L27/50A61L27/54A61L27/56
CPCA61L27/06A61L27/34A61L27/50A61L27/54A61L27/56A61L2300/112A61L2300/204A61L2300/404A61L2400/18A61L2430/12C08L79/02
Inventor 吴尧杨明刚蓝芳战晓辉罗斌
Owner SICHUAN UNIV
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