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Diclazuril solution and preparing method thereof

A technology of diclazuril and diclazuril, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, drug combinations, etc., can solve problems such as short action time, cross-resistance, and influence on curative effect, and achieve the goal of preparing The effect of simple process, wide source of raw materials and long storage time

Inactive Publication Date: 2018-06-22
河北金元康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing diclazuril preparations have the following defects: (1) because this product is more likely to cause coccidian drug resistance, even cross-drug resistance (toltrazuril), therefore, consecutive use must not exceed 6 months, rotation It is not advisable to use similar drugs such as Toltrazuril
(2) The action time of this product is short, and the effect basically disappears after one day of withdrawal. Therefore, broiler chickens must continue to use the drug to prevent outbreaks again
(4) The drinking water of diclazuril solution has a stable period of only 4 hours as stipulated in our country. Therefore, it must be prepared immediately after use, otherwise the curative effect will be affected, which will cause inconvenient industrial production, storage and transportation, and clinical use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A diclazuril solution comprises the following raw materials: 0.5 g of diclazuril, 60 g of dimethylamide, 2 g of povidone and 100 ml of polyethylene glycol 400. As the dimethylamide, dimethylformamide is used.

[0018] The preparation method of described diclazuril solution, concrete steps are as follows:

[0019] Step 1, adding half of the mass of povidone into dimethylformamide and dissolving it evenly to obtain the first mixed solution;

[0020] Step 2, adding diclazuril into the first mixed solution and heating to 65 degrees Celsius, stirring until completely dissolved to obtain the second mixed solution;

[0021] Step 3, adding the other half of povidone into polyethylene glycol 400 and completely dissolving it to obtain the third mixed solution;

[0022] Step 4: Add the third mixed liquid into the second mixed liquid and stir for 26 minutes to obtain the finished product.

Embodiment 2

[0024] A diclazuril solution comprises the following raw materials: 0.75 g of diclazuril, 64 g of dimethylamide, 2.8 g of povidone and 100 ml of polyethylene glycol 400. Povidone adopts povidone K30.

[0025] The preparation method of described diclazuril solution, concrete steps are as follows:

[0026] Step 1, adding half of the mass of povidone K30 into dimethylamide and dissolving evenly to obtain the first mixed solution;

[0027] Step 2, adding diclazuril into the first mixed solution and heating to 60 degrees Celsius, stirring until completely dissolved to obtain the second mixed solution;

[0028] Step 3, adding the other half of povidone K30 into polyethylene glycol 400 and completely dissolving it to obtain the third mixed solution;

[0029] Step 4, adding the third mixed liquid into the second mixed liquid and stirring for 28 minutes to obtain the finished product.

Embodiment 3

[0031] A diclazuril solution comprises the following raw materials: 0.9 g of diclazuril, 68 g of dimethylamide, 3.6 g of povidone and 100 ml of polyethylene glycol 400. As the dimethylamide, dimethylacetamide is used. Povidone adopts povidone K17.

[0032] The preparation method of described diclazuril solution, concrete steps are as follows:

[0033] Step 1, adding half of the mass of povidone K17 into dimethylacetamide and dissolving evenly to obtain the first mixed solution;

[0034] Step 2, adding diclazuril into the first mixed solution and heating to 68 degrees Celsius, stirring until completely dissolved to obtain the second mixed solution;

[0035] Step 3, adding the other half of povidone K17 into polyethylene glycol 400 and completely dissolving it to obtain the third mixed solution;

[0036] Step 4, adding the third mixed liquid into the second mixed liquid and stirring at a rotation speed of 360 rpm for 25 minutes to obtain the finished product.

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Abstract

The invention discloses a diclazuril solution and a preparing method thereof. The diclazuril solution is prepared from 0.5 g-1 g of diclazuril, 60 g-70 g of dimethylformamide, 2 g-4 g of povidone and100 ml to 400 ml polyethylene glycol. According to the diclazuril solution and the preparing method thereof, raw material sources are wide, the preparing technology is simple, the diclazuril is dissolved into a high polymer material, and is wrapped with the high polymer material, the diclazuril is slowly released from the high polymer material during dosing, and therefore the long acting effect isachieved; preservation time is long, the defects that an existing diclazuril solution must be presently prepared when needed, and the curative effect is easily influenced are overcome, and people canconveniently use the diclazuril solution.

Description

technical field [0001] The invention relates to a medicine, in particular to a diclazuril solution. Background technique [0002] Diclazuril belongs to the triazine benzyl nitrile compound, which is a new type, high efficiency and low toxicity anticoccidial drug, widely used in animal coccidiosis. The mechanism of action of diclazuril against coccidia is still unclear. The peak period of the main action on coccidia varies with different species of coccidia, such as the main action point on Eimeria tenella is in the sexual cycle of the second generation schizont coccidia. But the giant, Eimeria brucei schizont invalid. The point of action on Eimeria maxima is at the zygote stage of Eimeria brucei; it is highly effective on the microgametophyte stage of Eimeria brucei. Diclozolid also inhibited the formation of sporulated oocysts. According to clinical trials, the control effect of diclazuril on coccidia is superior to other conventionally applied anticoccidials and ionoph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/32A61K47/10A61K31/53A61P33/02
CPCA61K9/08A61K31/53A61K47/10A61K47/32
Inventor 田勇张乐清宁秀云商荣芳
Owner 河北金元康药业有限公司
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