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Microfluidic chip based on Morpho menelaus and manufacturing method thereof

A technology of microfluidic chips and manufacturing methods, applied in chemical instruments and methods, laboratory containers, measuring devices, etc., can solve problems such as large surface roughness, incompatibility, and limited microchannel resolution, and achieve Extensive sources of raw materials, rapid response, and the effect of promoting application

Active Publication Date: 2018-06-15
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, paper has a large surface roughness, which limits the resolution of microchannels; plastics are incompatible with some organic solvents and will adsorb analyte molecules; the processing costs of silicon and glass are high, and it is difficult Areas heavily used, etc.
In addition to the above problems, these substrate materials are disordered structures, resulting in uneven flow of liquids, and it is difficult to control the flow behavior of liquids.

Method used

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  • Microfluidic chip based on Morpho menelaus and manufacturing method thereof
  • Microfluidic chip based on Morpho menelaus and manufacturing method thereof
  • Microfluidic chip based on Morpho menelaus and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Microfluidic chip based on Morphobis:

[0036] Such as figure 1 As shown, the microfluidic chip based on Morpholipris provided by the present invention includes a test sample loading area 1, a fluorescently labeled antibody loading area, a capture antibody loading area, and a waste liquid area 6 that are connected in sequence, in which a fluorescent label is connected. The channel of the antibody loading area and the capture antibody loading area is two parallel channels, and the first fluorescently labeled antibody loading area 2 and the second fluorescently labeled antibody loading area 4 are arranged symmetrically on the passage, and the first capture antibody loading area 3 and the second capture antibody loading zone 5.

[0037] 2. The fabrication method of the microfluidic chip based on Morpholipae:

[0038] Such as figure 2 As shown, M in the figure represents a microfluidic chip (Microfluidic chip).

[0039] First, take a small piece of hindwing of Morph...

Embodiment 2

[0043] Same as Example 1, the difference is that the channel connecting the fluorescently labeled antibody loading area and the capture antibody loading area is a single channel, the manufacturing method is the same as that of Example 1, and the final detection effect is the same as that of Example 1.

Embodiment 3

[0045] Same as Example 1, the difference is that the channels connecting the fluorescently labeled antibody loading area and the capture antibody loading area are three parallel channels, the manufacturing method is the same as Example 1, and the final detection effect is the same as Example 1.

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Abstract

The invention discloses a microfluidic chip based on Morpho menelaus and a manufacturing method thereof. The microfluidic chip utilizes wings of Morpho menelaus as bases and through local hydrophilictreatment on the wing surfaces of Morpho menelaus, a hydrophilic channel is formed. The microfluidic chip comprises a test sample loading zone, a fluorescent-labeled antibody loading zone, a capture antibody loading zone and a waste liquid zone and the above zones are orderly communicated. The microfluidic chip combines a biological source ordered structure and a self-assembled photonic crystal layer to form a heterostructure, enhances the fluorescent signal of the marker, is used for improving the sensitivity of the immunoassay and can simultaneously detect a plurality of biomarkers. The manufacturing method has simple processes, utilizes raw materials with a wide source, realizes rapid multi-component detection at the same time, promotes the application of the ordered structure in the POCT technology and can be widely applied in the fields of biological analysis and clinical detection.

Description

technical field [0001] The invention relates to a microfluidic chip and a manufacturing method thereof, in particular to a microfluidic chip based on a Morphobis blue butterfly and a manufacturing method thereof. Background technique [0002] Point-of-care testing (POCT), also known as on-site testing and instant testing, is a fast and effective diagnostic analysis technology developed in recent years. The POCT diagnostic system has the advantages of fast, simple, economical, portable, and easy to handle, and can provide patients or untrained personnel with rapid and effective in vitro diagnostic results. However, the current POCT technology only detects one kind of analyte based on different detection principles, and cannot realize multiple analysis and detection, which limits the development of POCT. Therefore, the microfluidic chip analysis system with the advantages of integration, miniaturization, and rapid response can fully meet the needs of POCT, and is expected to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64G01N33/533B01L3/00
CPCB01L3/5027B01L2200/10B01L2300/0861B01L2300/161G01N21/6428G01N21/6486G01N33/533
Inventor 顾忠泽何珍珠高兵兵阿杜
Owner SOUTHEAST UNIV
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