Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Rare earth up-conversion nanometer diagnosis and treatment agent and preparation method thereof

A rare earth up-conversion, nanotechnology, applied in chemical instruments and methods, pharmaceutical formulations, echo/ultrasonic imaging agents, etc., to achieve the effect of remarkable effect, accurate diagnosis of curative effect, and broad application prospects

Inactive Publication Date: 2018-06-08
SHENZHEN UNIV
View PDF2 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main purpose of the present invention is to provide a rare earth up-conversion nano-diagnosis agent and a preparation method thereof, aiming at solving the problem of up-conversion nano-materials doped with trivalent rare earth erbium ions (Er ions) in the prior art. 3+ ) technical issues of luminous efficiency of fluoride nanocrystals

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Rare earth up-conversion nanometer diagnosis and treatment agent and preparation method thereof
  • Rare earth up-conversion nanometer diagnosis and treatment agent and preparation method thereof
  • Rare earth up-conversion nanometer diagnosis and treatment agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] In order to make the purpose, features and advantages of the present invention more obvious and understandable, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described The embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making creative efforts belong to the protection scope of the present invention.

[0022] Due to the doping of trivalent rare earth erbium ions (Er 3+ ) The technical problem that the luminous efficiency of the fluoride nanocrystal is low.

[0023] In order to solve the above-mentioned technical problems, the present invention proposes a preparation method of a rare earth up-conversion nano-diagnostic agent, comprising ste...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of a rare earth up-conversion nanometer diagnosis and treatment agent. The preparation method comprises the following steps: combining Er3+ doped up-conversion nanometer particles NaYF4 with an indocyanine green dye (ICG) molecule to form an ICG-LNPs compound; and modifying the ICG-LNPs compound by adopting modification of coupling polyethylene glycol so as to obtain DSPE-mPEG-ICG-LNPs. The invention also discloses the rare earth up-conversion nanometer diagnosis and treatment agent. By adopting the advantage that the rare earth up-conversion nanometer material NaYF4:Er is emitted in a near-infrared second area, the ICG molecule is coupled with the nanometer material, the ICG can strengthen 1520 nm of Er3+ to emit light, and the technical problem that an up-conversion nanometer material doped trivalent rare earth erbium ion (Er3+) fluoride nanocrystal is low in luminous efficiency in the prior art is solved.

Description

technical field [0001] The invention relates to the field of up-conversion luminescent materials, in particular to a rare earth up-conversion nano-diagnosis and treatment agent and a preparation method thereof. Background technique [0002] Rare earth-doped phosphors (LNPs) can emit visible light or near-infrared light when excited by near-infrared light. This material has been widely used in biosensing, bioimaging, and drug release, especially in multimodal Functionality is particularly important in biological applications of nanotherapeutics. This requires that nano-therapeutic agents not only have therapeutic purposes, but also have the function of real-time diagnosis and monitoring. [0003] Doped with trivalent rare earth erbium ions (Er 3+ ) fluoride nanocrystals are one of the commonly used nanomaterials in optical bioimaging. This nanomaterial emits green visible light (540nm) and red visible light (650nm) under near-infrared light 808nm laser excitation, and its ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C09K11/02C09K11/85A61K49/22A61K49/00A61K47/60
CPCA61K49/0034A61K49/0054A61K49/221C09K11/02C09K11/7791
Inventor 王丹宋军屈军乐
Owner SHENZHEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com