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Plastic hollow polymer microspheres with microchannels on surfaces as well as preparation method and application of microspheres

A technology of polymers and micropores, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, etc. Problems such as inconvenient operation

Active Publication Date: 2018-06-08
GUANGZHOU BLUE MOON IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In summary, the suspension polymerization method, the template method, and the self-assembly method need to go through high temperature, calcination, organic solvent swelling or etching in the preparation process, and there are many inconveniences in the operation method, which is not suitable for industrial production.
The preparation process of surface non-permeable hollow or porous microspheres is prepared after plugging the pores on the surface of the microspheres. Because the pores before plugging are relatively large, reaching micron level, their permeability is very obvious without plugging. However, the plugging step increases the operational difficulty and uniformity of the preparation method

Method used

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  • Plastic hollow polymer microspheres with microchannels on surfaces as well as preparation method and application of microspheres

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preparation example Construction

[0059] In a preferred embodiment of the present invention, the preparation method includes the following steps: firstly adding the organic solvent into the aqueous solution in which the colloidal protective agent is dissolved, stirring at room temperature to disperse the organic solvent, and gradually raising the temperature to obtain water an oil-in-type micro-droplet suspension; preparing a mixed solution including a polymerization monomer, an initiator and a cross-linking agent; adding the mixed solution dropwise to the suspension. By controlling the amount of the organic solvent, the polymerization reaction is gradually carried out on the surface of the micro-droplet, thereby forming a cross-linked polymer shell on the surface of the micro-droplet. At the initial stage of polymer shell formation, the organic solvent wrapped in the polymer shell is slowly volatilized by controlling the temperature of the system to form hollow polymer plastic microspheres with micropores on t...

Embodiment 1

[0080] A method for preparing cross-linked polymethyl methacrylate-n-butyl acrylate-isooctyl acrylate hollow polymer plastic microspheres with micropores on the surface, the specific operation steps are as follows:

[0081] (1) The reactor equipped with a stirrer and a reflux condensing device is placed in a water bath, and successively add 5% polyvinyl alcohol 1788 (molecular weight is 1700, alcoholysis degree is 88%) aqueous solution 300.0% to the reactor g and 57.0 g of methylcyclohexane, adjust the stirring speed to 600 rpm / min, stir at room temperature for 10 minutes, start to heat up and stabilize the system temperature at 75 ° C, forming a stable oil-in-water micro-droplet suspension.

[0082] (2) 12.0g n-butyl acrylate, 24.0g methyl methacrylate, 5.6g isooctyl acrylate and 7.7g methylcyclopentadiene were placed in a beaker, and 1.2g azobisisoheptanonitrile was added, Stir until the diisoheptanonitrile is completely dissolved to form a uniform mixed solution.

[0083] ...

Embodiment 2

[0091] A method for preparing cross-linked polymethyl methacrylate-n-butyl acrylate-isooctyl acrylate hollow polymer plastic microspheres with micropores on the surface, the specific operation steps are as follows:

[0092] (1) The reactor equipped with a stirrer and a reflux condensing device is placed in a water bath, and successively add 5% polyvinyl alcohol 1788 (molecular weight is 1700, alcoholysis degree is 88%) aqueous solution 300.0% to the reactor g and 29.4g cyclohexane, adjust the stirring speed to 500rpm / min, stir at room temperature for 10 minutes, start to heat up and stabilize the system temperature at 60°C, forming a stable oil-in-water micro-droplet suspension.

[0093] (2) 8.0g n-butyl acrylate, 24.0g methyl methacrylate, 5.6g isooctyl acrylate and 5.7g methylcyclopentadiene are placed in a beaker, and 0.7g benzoyl peroxide is added, stirred Until the benzoyl oxide is completely dissolved to form a uniform mixed solution.

[0094] (3) Add the mixed solution...

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Abstract

The invention discloses plastic hollow polymer microspheres with microchannels on surfaces as well as a preparation method and an application of the microspheres. The particle size of the plastic microspheres is 1-300 mu m, the thickness of a shell is 0.01-100 mu m, and the diameter of the microchannels is smaller than or equal to 0.05 mu m. The microspheres have elastic non-restorability, and after cavities of the plastic hollow polymer microspheres are filled with some substances, the substances in the cavities can be slowly released via the microchannels of the microspheres without externalforces; the microspheres are deformed and substances in the cavities are released quickly under the action of external forces; the deformed microspheres cannot restore when the external forces are removed. The microspheres belong to a macromolecular polymer material, have low density, good thermal insulation, sound insulation, light scattering performance and the like and can be widely applied tofields of medical treatment, cosmetics, cleaning / caring supplies (such as cleaning agents, caring agents and the like), sewage treatment, catalyst loading and the like.

Description

technical field [0001] The invention relates to a hollow polymer plastic microsphere with micropores on the surface, a preparation method and application thereof, and belongs to the field of polymer functional materials. Background technique [0002] Hollow polymer microsphere is a microsphere with a polymer shell and a cavity structure inside. This microsphere has low density, thermal insulation, acoustic insulation, good light scattering and other properties, and is widely used in catalyst loading. , drug sustained release, cosmetic coating, sewage treatment and other fields. [0003] At present, the main methods for preparing hollow polymer microspheres include suspension polymerization, self-assembly, and solvent evaporation, as well as acid-base swelling, emulsion polymerization, and template methods. For the suspension polymerization method, firstly, the W / O type small droplets are prepared by the Pickering emulsification method, and then these small droplets are disp...

Claims

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Application Information

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IPC IPC(8): C08F220/14C08F220/18C08F232/06C08J3/16C08J3/24A61K9/16A61K47/32A61K8/81A61Q19/10
CPCA61Q19/10A61K8/8152A61K9/1635C08F220/14C08J3/16C08J3/24A61K2800/56A61K2800/412C08J2333/12C08F220/1804C08F220/1808C08F220/18C08F232/06C08F220/1802
Inventor 郑翔龙蒋赞
Owner GUANGZHOU BLUE MOON IND
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