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Use of indolepropionic acid in the preparation of medicines for preventing and/or treating side effects of tumor radiotherapy

A tumor radiotherapy and indole propionic acid technology, which is applied in the field of medicine, can solve the problems such as the limitation of the surgical process of rejection reaction, the lack of protection, and the short duration of the drug effect of amifostine.

Active Publication Date: 2020-09-25
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These intestinal toxic side effects caused by radiation therapy have seriously affected the quality of life of the patient, and even endangered the patient's life
[0005] Existing approaches to prevent side effects from ionizing radiation include bone marrow transplantation and administration of the anti-radiation drug Amifostine, both of which have certain drawbacks and limitations
As one of the organ transplantation techniques, the bone marrow transplantation technique is to inject normal bone marrow into the patient's body through the vein to replace the diseased bone marrow, rebuild the patient's hematopoietic function and immune function, and achieve the purpose of improving the hematopoietic system after irradiation. The rejection reaction and complicated surgical procedure limit the wide application of this technology
Amifostine is mainly used for the adjuvant treatment of various cancers. As a compound that does not exist in the body, its severe side effects (such as: hypotension, nausea, vomiting, dizziness, fever, lethargy, sneezing, etc.) limit its application the crowd
In addition, amifostine showed effective protection only when administered immediately before chemoradiotherapy, but not hours before or after chemoradiotherapy
[0006] In summary, due to the side effects of amifostine after administration and the short duration of its drug effect after taking it, its wide application in clinical practice is limited.

Method used

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  • Use of indolepropionic acid in the preparation of medicines for preventing and/or treating side effects of tumor radiotherapy
  • Use of indolepropionic acid in the preparation of medicines for preventing and/or treating side effects of tumor radiotherapy
  • Use of indolepropionic acid in the preparation of medicines for preventing and/or treating side effects of tumor radiotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1: Survival rate of mice after whole-body irradiation with γ-rays and weight detection after partial abdominal irradiation with γ-rays.

[0054] 1. Experimental animals:

[0055] C57BL / 6J mice, 6-8 weeks old, weighing about 20g, male, were randomly divided into three groups: irradiation group, low concentration indole propionic acid group and high concentration indole propionic acid group, 30 mice in each group.

[0056] 2. Model establishment:

[0057] After adopting 0.3% chloral hydrate to anesthetize experimental mouse (anesthetic dose is 1ml / g), use 40Exactor carried out local irradiation of γ-ray abdomen on the whole abdomen of mice ( 40Exactor comes with a partial irradiation mold, the entire abdomen is fully exposed), the absorbed dose is 15Gy, and the dose rate is 1Gy / min.

[0058] 3. Administration method:

[0059] Indole propionic acid group: start administration 24 hours before irradiation, administration method: intragastric administration of i...

Embodiment 2

[0066] Example 2: Detection of intestinal goblet cells in mice after abdominal local irradiation with γ-rays.

[0067] 1. Experimental animals:

[0068] C57BL / 6J mice, 6-8 weeks old, weighing about 20g, male, were randomly divided into three groups: blank group, simple irradiation group and indole propionic acid group, 30 mice in each group.

[0069] 2. Model establishment:

[0070] After adopting 0.3% chloral hydrate to anesthetize experimental mouse (anesthetic dose is 1ml / g), use 40Exactor carried out local irradiation of γ-ray abdomen on the whole abdomen of mice ( 40Exactor comes with a partial irradiation mold, the entire abdomen is fully exposed), the absorbed dose is 15Gy, and the dose rate is 1Gy / min.

[0071] 3. Administration method:

[0072] Indole propionic acid group: start administration 24 hours before irradiation, administration method: intragastric administration of indole propionic acid liquid, once a day at 2 pm, continuous administration for 10 days;...

Embodiment 3

[0080] Example 3: Detection of colon length in mice after localized abdominal irradiation with γ-rays.

[0081] 1. Experimental animals:

[0082] C57BL / 6J mice, 6-8 weeks old, weighing about 20g, male, were randomly divided into three groups: blank group, simple irradiation group and indole propionic acid group, 30 mice in each group.

[0083] 2. Model establishment:

[0084] After adopting 0.3% chloral hydrate to anesthetize experimental mouse (anesthetic dose is 1ml / g), use 40Exactor carried out local irradiation of γ-ray abdomen on the whole abdomen of mice ( 40Exactor comes with a partial irradiation mold, the entire abdomen is fully exposed), the absorbed dose is 15Gy, and the dose rate is 1Gy / min.

[0085] 3. Administration method:

[0086] Indole propionic acid group: start administration 24 hours before irradiation, administration method: intragastric administration of indole propionic acid liquid, once a day at 2 pm, continuous administration for 10 days; dosage...

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Abstract

The invention belongs to the technical field of medicine, and relates to application of indolepopionic acid to preparation of drugs for preventing and / or treating tumor radiotherapy side effect. Through research, the fact that indolepopionic acid can obviously improve intestinal injury of mice, caused by gama ray irradiation, is found, the improvement shows that the survival rate of laboratory mice is obviously improved, the weight is risen again, the intestinal inflammation level is obviously reduced, and paradoxical reaction of the laboratory mice does not occur, the fact that indolepopionicacid can be effectively applied to the prevention and / or treatment of tumor radiotherapy side effect is shown, and the indolepopionic acid is low in toxic and side effect, and effective before and after being taken, and has a wide application potential.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the use of indole propionic acid (IPA) in the preparation of drugs for preventing and / or treating side effects of tumor radiotherapy, in particular to the use of indole propionic acid in the preparation of drugs for preventing and / or treating side effects of tumor radiotherapy. The use of drugs for side effects of abdominal tumor radiotherapy. Background technique [0002] Epidemiological studies have pointed out that colon cancer, rectal cancer, prostate cancer, liver cancer and other pelvic and abdominal tumors are at the forefront of the global morbidity and mortality. As a traditional and effective tumor treatment method, radiotherapy is widely used in the preoperative, intraoperative and postoperative period of the above-mentioned pelvic and abdominal tumors. [0003] At the same time, due to its own characteristics, when radiation therapy "kills" tumor tissue, it will inevi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/405A61P1/08A61P1/12A61P1/00A61P3/00
CPCA61K31/405
Inventor 崔明樊赛军肖惠文李源张书琴
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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