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A kind of compound salvia miltiorrhiza film-coated tablet and its preparation process

A technology of film coating and compound salvia miltiorrhiza, applied in sugar-coated pills, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve the effects of high active ingredient content, overcoming deliquescence, and good storage stability

Active Publication Date: 2020-12-18
GUANGDONG YILI GROUP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation steps of Compound Danshen Tablets in this patent are not much different from the traditional process, and cannot overcome the above-mentioned problems

Method used

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  • A kind of compound salvia miltiorrhiza film-coated tablet and its preparation process
  • A kind of compound salvia miltiorrhiza film-coated tablet and its preparation process
  • A kind of compound salvia miltiorrhiza film-coated tablet and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] The preparation of embodiment 1 composite resin gel powder

[0069] The preparation raw materials of composite resin gel powder are shown in the following table:

[0070]

[0071] Preparation steps:

[0072] (1) Dissolve nano-hydroxyapatite in 0.1 mol / L dilute hydrochloric acid solution, discard the precipitate, then add 0.1 mol / L NaOH solution to make nano-hydroxyapatite settle, wash repeatedly with water, and dry. Crush into fine powder, pass through 100 mesh, and set aside;

[0073] (2) Mix sodium alginate with water, heat and stir in an 80°C water bath until completely dissolved, and make a solution with a mass volume concentration of 15%, then cool to 60°C, and add the nano-hydroxyapatite obtained in step (1) , acrylic acid, stirred for 15 minutes, then added ammonium persulfate with 0.05% weight of sodium alginate, reacted at 65°C for 3 hours, cooled to room temperature, dried, and crushed to 50-100 mesh to obtain composite resin gel powder.

Embodiment 2-6

[0074] Example 2-6 Preparation of Compound Salvia Miltiorrhiza Film-Coated Tablet

[0075] The preparation raw materials of compound salvia miltiorrhiza film-coated tablet are shown in the following table:

[0076]

Embodiment 2

[0077] Embodiment 2 preparation steps:

[0078] A coating liquid preparation:

[0079] Mix the composite resin gel powder, glycerin and 90% (v / v) ethanol water of formula quantity evenly, stir for 30 minutes, make uniform film coating liquid, set aside;

[0080] B tablet core preparation:

[0081] (1) Wash the notoginseng, dry it, and carry out ultrafine grinding to obtain the superfine powder of notoginseng, which is set aside;

[0082] (2) Wash the salvia miltiorrhiza, cut it into small slices, dry it, then pass it into the air with a density of 1.29kg / m3, pressurize it to 8MPa at room temperature, puff it for 5min, release the pressure instantly, and then replace the gas Form carbon dioxide with a density of 1.98kg / m3, pressurize it to 10MPa at room temperature, puff it for 5 minutes, release the pressure instantly, and obtain material A;

[0083] (3) According to the solid-liquid ratio of 1g:25mL, add ethanol aqueous solution with a volume concentration of 60% to materi...

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Abstract

The invention discloses a compound salvia miltiorrhiza film-coated tablet and a preparation process thereof. The film-coated tablet is composed of a tablet core and a film coating layer, wherein the weight of the film coating layer accounts for 1 to 3% of the weight of the tablet core, and the described tablet core includes raw materials in the following weight ratio: Danshen, Panax notoginseng and The borneol, the film coating layer includes the following raw materials in weight ratio: composite resin gel powder, glycerin and 90% ethanol water. The invention adopts a special formula and a preparation process, so that the obtained compound salvia miltiorrhiza film-coated tablet has high active ingredient content, better bioavailability and storage stability.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a compound Danshen film-coated tablet and a preparation process thereof. Background technique [0002] Compound Danshen Tablets is a variety recorded in the Chinese Pharmacopoeia. It is refined from the three herbs of Danshen, Panax notoginseng and Borneol. Among them, Danshen promotes blood circulation and relieves pain, Sanqi promotes blood circulation and nourishes qi, and Borneol guides the meridians to complement each other. It has the functions of promoting blood circulation and removing blood stasis. , The effect of regulating qi and relieving pain, used for chest obstruction caused by qi stagnation and blood stasis, is a commonly used Chinese patent medicine in clinic. [0003] The traditional preparation process of Compound Salvia Miltiorrhiza Tablets is as follows: Radix Salviae Miltiorrhizae is heated and refluxed with ethanol for 1.5 ho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K36/537A61P9/10A61K31/045
CPCA61K9/286A61K31/045A61K36/258A61K36/537A61K2236/333A61K2236/51A61K2300/00
Inventor 张浩潘洁丽曾胜曾佐达梁烽焱
Owner GUANGDONG YILI GROUP PHARMA
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