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Anti-platelet aggregation justicia procumbens extract as well as preparation method and application thereof

An anti-platelet aggregation and extract technology, applied in the field of medicine, can solve the problems of low utilization rate, loss, complicated procedures, etc., and achieve the effects of improving utilization rate, high safety and strong target.

Pending Publication Date: 2018-06-01
HUBEI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the technical scheme of CN104086537A still has defects and deficiencies: (1) the acanthidine A prepared by the preparation method is a single active ingredient, which leads to the loss of other active ingredients with anti-platelet aggregation in the acanthus medicinal material, so that the acanthus medicinal material is not fully obtained. Utilization, utilization rate is low; (2) the operation of preparing Jaxantine A is loaded down with trivial details, and preparation method needs to be equipped with high-speed countercurrent chromatography, has reduced the versatility of preparation method

Method used

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  • Anti-platelet aggregation justicia procumbens extract as well as preparation method and application thereof
  • Anti-platelet aggregation justicia procumbens extract as well as preparation method and application thereof
  • Anti-platelet aggregation justicia procumbens extract as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0049] (1) 500g of the medicinal material of Juechi was extracted by percolation with 10 times the amount (W / V) of 80% (V / V) ethanol, and the extraction speed of the percolation was 10mL / min per kilogram of the medicinal material of Juech to obtain the extract;

[0050] (2) Ethanol is recovered from the extract under reduced pressure to obtain a concentrated solution. The concentrated solution is extracted twice with petroleum ether and ethyl acetate successively, and the volume ratio of each dosage to the concentrated solution is 1:1. The solvent is recovered from the ester extract under reduced pressure, and the ethyl acetate part extract is obtained after drying;

[0051] (3) Put the ethyl acetate extract on a silica gel column, elute with a mixed solvent of petroleum ether-ethyl acetate (1:3), the elution volume is 3L, and the eluent is dried to obtain the anti-platelet aggregation acanthus extract .

Embodiment 2

[0053] (1) 500g of Juechi medicinal material was ultrasonically treated with 5 times the amount (W / V) of 50% (V / V) ethanol (power 250W, frequency 40kHz) for 30 minutes to obtain an extract;

[0054] (2) The extract solution reclaims ethanol under reduced pressure to obtain a concentrated solution. The concentrated solution is extracted 3 times with ethyl acetate, and the volume ratio of each dosage to the concentrated solution is 0.5:1. Ethyl acetate part extract;

[0055] (3) Put the ethyl acetate part extract on a silica gel column, elute with a mixed solvent of petroleum ether-acetone (4:1), the elution volume is 5L, and the eluent is dried to obtain the anti-platelet aggregation acanthus extract.

Embodiment 3

[0057] (1) 500g Juechi medicinal material was reflux extracted twice with 20 times the amount (W / V) of 90% (V / V) methanol, each time for 1 hour, and the two extracts were combined;

[0058] (2) The extraction solution reclaims methanol under reduced pressure to obtain a concentrated solution. The concentrated solution is extracted twice with normal hexane and ethyl acetate. The volume ratio of each normal hexane and ethyl acetate to the concentrated solution is 1.5:1, and the normal hexane is discarded. Liquid, the ethyl acetate extract is decompressed and the solvent is recovered, and the ethyl acetate part extract is obtained after drying;

[0059] (3) Put the extract from the ethyl acetate part on a gel column, elute with a mixed solvent of chloroform-methanol (2:1), and the elution volume is 10 times the column volume, and the eluent is dried to obtain the anti-platelet aggregation acanthus extract thing.

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Abstract

The invention discloses an anti-platelet aggregation justicia procumbens extract as well as a preparation method and the application thereof. The justicia procumbens extract provided by the inventionat least contains 6'-hydroxylipotometine B and new lipotometine B; and the preparation method of the justicia procumbens extract comprises the following steps: extracting by an organic solvent of 50 to 90 percent (V / V) in an amount which is 5 to 20 times (W / V), decompressing an extracting liquid to recover a solvent, extracting by using ethyl acetate, enabling the obtained ethyl acetate part extractum to go on a chromatographic column, eluting with a mixed organic solvent, combining the eluant and drying to obtain the justicia procumbens extract. The justicia procumbens extract prepared by themethod can effectively resist platelet aggregation, has the advantages of low toxicity and high medication safety and can be applied to preparation of cardiovascular medicines or health-care food; and the justicia procumbens extract can serve as an active component applied to the preparation of soft capsules, granules, capsules and the like.

Description

technical field [0001] The present invention relates to an anti-platelet aggregation traditional Chinese medicine extract and its preparation method and application, in particular to an anti-platelet aggregation acanthus extract and its preparation method and application, belonging to the technical field of medicine. Background technique [0002] Acanthus is derived from the dry whole plant of Justicia procumbens L. Also known as Jueqing, Xiangsu, Old Motherwort, Fly's Wing, etc., it was once included in the "Pharmacopia of the People's Republic of China" (1977 edition). It is an annual creeping herb, the aboveground part is generally 15-50cm long, and it grows in damp places. It is mainly distributed in central China, southeast coast, southwest and Taiwan Province. It is mainly distributed in Southeast Asia and Africa abroad, and is rich in resources. This product is good at clearing heat and detoxifying, promoting dampness and eliminating stagnation, promoting blood circu...

Claims

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Application Information

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IPC IPC(8): A61K36/19A61P7/02A61P9/00A23L33/105
CPCA23V2002/00A61K36/19A61K2236/333A61K2236/55A23L33/105A23V2200/30A23V2250/21
Inventor 杨艳芳吴和珍刘博陆毅尤朋涛谢周涛熊唯琛熊羿屹孙媛
Owner HUBEI UNIV OF CHINESE MEDICINE
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