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Application of medicinal composition containing eucalyptol, limonene and alpha-pinene in preparing drug for treating upper respiratory bacterial infection

A technology for upper respiratory tract and bacterial infection, which is applied to the application field of a pharmaceutical composition containing eucalyptol, limonene and α-pinene in the preparation of a drug for treating bacterial infection of the upper respiratory tract, achieving a clear chemical structure and composition, and high safety. High, promotes the effect of returning to normal

Inactive Publication Date: 2018-05-29
BEIJING GRAND JOHAUM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no information in the prior art about the use of pharmaceutical compositions containing eucalyptol, limonene and α-pinene in the treatment of bacterial infections of the upper respiratory tract and the inflammation caused by them, especially in the pharynx or larynx. Inflammation-induced applications have been reported

Method used

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  • Application of medicinal composition containing eucalyptol, limonene and alpha-pinene in preparing drug for treating upper respiratory bacterial infection
  • Application of medicinal composition containing eucalyptol, limonene and alpha-pinene in preparing drug for treating upper respiratory bacterial infection
  • Application of medicinal composition containing eucalyptol, limonene and alpha-pinene in preparing drug for treating upper respiratory bacterial infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Nebulized inhaler

[0029] The prescription for aerosol inhalation dosage form is: 7.2g eucalyptol (purity 85.0%), 4.5g limonene (purity 96.0%), 3.82g α-pinene (purity 94.0%) (eucalyptol, α-pinene) The weight ratio of the total weight to the limonene is 22:9, and the three components account for 1.55% of the total weight of the prescription), 15.0g poloxamer 407, 5.0g polyoxyethylene sorbitan monooleate, 12.0g chlorine Dilute with sodium chloride, 2.0g vitamin C, 0.1g carbomer, and 0.9% saline to 1000mL.

[0030] Preparation method: First pass the solid excipients through an 80-mesh sieve for later use. Mix eucalyptol, limonene and α-pinene into poloxamer 407 and polyoxyethylene sorbitan monooleate, stir in vacuum for 40 minutes, and add 70% of the prescription amount of physiological saline was stirred for 5 minutes for high-pressure homogenization twice, vitamin C and carbomer were added, potassium dihydrogen phosphate and disodium hydrogen phosphate were added to adjust ...

Embodiment 2

[0032] Enteric-coated soft capsules

[0033] The content of the enteric-coated soft capsule is prescribed as follows: eucalyptol 1.6 kg, limonene 1.05 kg, α-pinene 0.35 kg, and soybean oil 1.0 kg.

[0034] The prescription of the capsule shell of the enteric soft capsule is: 1 part by weight gelatin, 1.1 parts by weight of water, and 0.35 parts by weight of glycerin; the enteric coating is composed of 6 parts by weight of polyacrylic resin II, 12 parts by weight of polyacrylic resin III, and 4.5 parts by weight of castor. Sesame oil, 4.5 parts by weight of polyethylene phthalate, 2 parts by weight of polysorbate 80, and 1.25 parts by weight of polyethylene glycol 6000.

[0035] The content of the enteric soft capsule is prepared by pressing, shaping, and washing the soft capsule, and then directly wrapping a disposable molded polymer enteric coating material outside the capsule shell.

Embodiment 3

[0037] Restore and regulate the balance of flora

[0038] The composition of the pharmaceutical composition used in this example is as follows (mass ratio of eucalyptol, limonene and α-pinene):

[0039] Group a: Eucalyptus 18.0%-35.0%, Limonene 44.0%-60.0%, α-Pinene 25.0%-30.0%;

[0040] Group b: Eucalyptol 35.0%-55.0%, Limonene 32.0%-44.0%, α-Pinene 10.0%-25.0%;

[0041] Group c: Eucalyptus 55.0%-63.0%, Limonene 15.0%-32.0%, α-Pinene 5.0%-10.0%.

[0042] Take three groups of pharmaceutical compositions from group a. The mass ratios of eucalyptol, limonene and α-pinene in the three groups are as follows:

[0043] (1) Eucalyptus 18.0%, limonene 55.0%, α-pinene 27.0%;

[0044] (2) Eucalyptus 25.0%, limonene 60.0%, α-pinene 25.0%;

[0045] (3) Eucalyptus oil 33.0%, limonene 44.0%, α-pinene 29.0%.

[0046] Take three groups of pharmaceutical compositions from group b. The mass ratios of eucalyptol, limonene and α-pinene in the three groups are as follows:

[0047] (4) Eucalyptus oil 36.0%, limon...

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Abstract

The invention provides application of a medicinal composition containing eucalyptol, limonene and alpha-pinene in preparing a drug for treating upper respiratory bacterial infection. The mass ratio ofthe eucalyptol to the limonene to the alpha-pinene in the medicinal composition is (18.0 to 63.0 percent) to (15.0 to 60.0 percent) to (5.0 to 30.0 percent). According to the medicinal composition disclosed by the invention, the medicinal composition containing the eucalyptol, the limonene and the alpha-pinene is used for treating upper respiratory infection, in particular to pharyngitis, amygdalitis or laryngitis and has a good effect on the treatment of upper respiratory tract.

Description

Technical field [0001] The invention relates to the application of a pharmaceutical composition containing eucalyptol, limonene and alpha-pinene in the preparation of a medicine for treating upper respiratory tract bacterial infection, especially pharyngitis, tonsillitis or laryngitis caused by upper respiratory tract bacterial infection. Background technique [0002] Upper respiratory tract infection refers to pathogens that invade the nose and throat, causing symptoms such as the common cold, acute viral pharyngitis, laryngitis, tonsillitis, and bronchitis. If it is not treated in time, it will lead to complications, secondary bacterial infection at the infected site, spreading backward from the nasopharynx and throat, leading to otitis media, and bronchitis and pneumonia. About 90% of upper respiratory tract infections are caused by viruses, and bacterial infections can occur directly or after viral infections. Bacterial infections of the upper respiratory tract are mainly ca...

Claims

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Application Information

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IPC IPC(8): A61K31/35A61K31/015A61P31/04A61P11/00A61P11/04
CPCA61K31/015A61K31/35A61K2300/00
Inventor 石江林霍扬扬
Owner BEIJING GRAND JOHAUM PHARMA CO LTD
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