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Antibacterial hemostatic sponge

A hemostatic sponge and hyaluronic acid technology, applied in the field of medical sponges, can solve problems such as lack of elasticity, poor comfort, and shedding of blood scabs, achieve good biocompatibility, reduce wound infection, and improve antibacterial performance

Inactive Publication Date: 2018-05-25
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostatic effect of this kind of hemostatic material is not good, and the material is non-degradable, easy to adhere to the blood scab, and it is easy to cause the blood scab to fall off during the removal process, causing re-bleeding
The second is non-degradable hydrogel materials, represented by PVA. This type of hydrogel has good blood-absorbing performance, but due to non-degradation, there is also the problem of re-bleeding during the removal process.
However, due to a large number of hydrogen bonds in the natural polymer, this type of hemostatic material is relatively rigid, and the sponge prepared by it is usually brittle and lacks elasticity. Patients who use it have a foreign body sensation and poor postoperative comfort.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] This embodiment 1 provides a bacteriostatic hemostatic sponge, the bacteriostatic hemostatic sponge consists of the following components by weight percentage: hyaluronic acid 3%, polyvinyl alcohol 10%, collagen 5%, silk fibroin powder 25% , Chitosan 15%, glycerol 5%, sulfadiazine silver salt 5% and the balance of purified water.

[0018] The preparation method of the antibacterial hemostatic sponge includes the following steps:

[0019] (1) Place the polyvinyl alcohol in 30% purified water, heat it to dissolve, keep it warm for use, and obtain a polyvinyl alcohol solution;

[0020] (2) Add the silver sulfadiazine salt to the glycerin and stir evenly to obtain mixture B;

[0021] (3) Soak the chitosan in the remaining purified water overnight, then heat in a water bath to dissolve, then add the polyvinyl alcohol solution, stir evenly, and cool to 45°C, then add hyaluronic acid, collagen, and silk fibroin powder And Mixture B, stir well, freeze-dry, freeze-dry temperature is -40...

Embodiment 2

[0023] This embodiment 2 provides a bacteriostatic hemostatic sponge, the bacteriostatic hemostatic sponge consists of the following components by weight percentage: hyaluronic acid 5%, polyvinyl alcohol 15%, collagen 3%, silk fibroin powder 30% , Chitosan 10%, glycerol 8%, sulfadiazine silver salt 7% and the balance of purified water.

[0024] The preparation method of the antibacterial hemostatic sponge includes the following steps:

[0025] (1) Place the polyvinyl alcohol in 30% purified water, heat it to dissolve, keep it warm for use, and obtain a polyvinyl alcohol solution;

[0026] (2) Add the silver sulfadiazine salt to the glycerin and stir evenly to obtain mixture B;

[0027] (3) Soak the chitosan in the remaining purified water overnight, then heat in a water bath to dissolve, then add the polyvinyl alcohol solution, stir evenly, and cool to 45°C, then add hyaluronic acid, collagen, and silk fibroin powder And Mixture B, stir well, freeze-dry, freeze-dry temperature is -35...

Embodiment 3

[0029] This example 3 provides a bacteriostatic hemostatic sponge, which consists of the following components by weight percentage: hyaluronic acid 1%, polyvinyl alcohol 12%, collagen 1%, silk fibroin powder 20% , Chitosan 12%, glycerol 3%, sulfadiazine silver salt 3% and the balance of purified water.

[0030] The preparation method of the antibacterial hemostatic sponge includes the following steps:

[0031] (1) Place the polyvinyl alcohol in 30% purified water, heat it to dissolve, keep it warm for use, and obtain a polyvinyl alcohol solution;

[0032] (2) Add the silver sulfadiazine salt to the glycerin and stir evenly to obtain mixture B;

[0033] (3) Soak the chitosan in the remaining purified water overnight, then heat in a water bath to dissolve, then add the polyvinyl alcohol solution, stir evenly, and cool to 45°C, then add hyaluronic acid, collagen, and silk fibroin powder And Mixture B, stir evenly, freeze-dry, freeze-dry temperature is -45°C, time is 50min, to obtain the...

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PUM

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Abstract

The invention discloses an antibacterial hemostatic sponge. The antibacterial hemostatic sponge comprises hyaluronic acid, polyvinyl alcohol, collagen, silk fibroin powder, chitosan, glycerin and sulfadiazine silver salt. The antibacterial hemostatic sponge which is a porous composite material has the advantages that the antibacterial hemostatic sponge is good in biocompatibility, dialysis performance, blood absorption performance, antibacterial performance, adhesion resistance and mechanical performance and high in use comfortableness, and the used sulfadiazine silver salt effectively increases the antibacterial performance of the sponge and reduces probability of wound infection.

Description

Technical field [0001] The invention relates to a medical sponge, in particular to a bacteriostatic and hemostatic sponge. Background technique [0002] Hemostasis is an important part of various operations and trauma first aid. In wound first aid and surgical operations, wound bleeding and bleeding are frequently encountered problems. A large amount of blood loss can endanger life and increase the chance of infection, thus affecting the operation. The success rate. Hemostatic material is an important tool for surgical hemostasis. It is mainly used to control bleeding, cover and bandage the wound as soon as possible, isolate the wound from the outside world to reduce the chance of infection, and create good wound conditions for debridement. Among them, hemostatic sponge is currently the most used hemostatic material in surgery. [0003] Throughout the development of hemostatic materials, it has gone through the following four stages: First, non-degradable materials, represented b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/02A61L24/06A61L24/08A61L24/10A61L24/00
CPCA61L24/0015A61L24/0036A61L24/02A61L24/06A61L24/08A61L24/102A61L24/108A61L2300/104A61L2300/404A61L2400/04C08L5/08C08L29/04C08L89/00
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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