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Glipizide lipid nanoparticle solid preparation

A technology for glipizide lipid and solid preparation, which is applied in the field of medicine and achieves the effects of high encapsulation efficiency, narrow particle size distribution and improved quality

Active Publication Date: 2018-05-18
DISHA PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] To solve the technical defects of existing glipizide preparations, provide a solid preparation of glipizide lipid nanoparticles prepared by solid lipid nanoparticle technology

Method used

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  • Glipizide lipid nanoparticle solid preparation
  • Glipizide lipid nanoparticle solid preparation
  • Glipizide lipid nanoparticle solid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 Preparation of Glipizide Lipid Nanoparticle Tablets

[0046] (1) Preparation of Glipizide Solid Lipid Nanoparticles

[0047] The prescription is as follows:

[0048] Glipizide 10 g

[0049] Trilaurin 140 g

[0050] Tween 80 80 g

[0051] Chitosan 28 g

[0052] The preparation method is as follows:

[0053] (a) Add 140 g of trilaurin to 500 mL of a mixed solution of ethanol and acetone with a volume ratio of 1:1, heat in a constant temperature water bath at 55°C, stir to dissolve, then add 10 g of glipizide, and stir Make it dissolve, constitute the organic phase, and set aside;

[0054] (b) Add 80 g of Tween (80) and 28 g of chitosan into 500 mL of purified water, heat in a constant temperature water bath at 55 °C, stir to dissolve, and form a water phase for later use;

[0055] (c) Under the condition of stirring at 800 rpm, slowly add the organic phase to the water phase, keep the temperature at 55 °C, and stir for 30 minutes;

[0056] (d) Concentrat...

Embodiment 2

[0072] Example 2 Preparation of Glipizide Lipid Nanoparticle Tablets

[0073] (1) Preparation of Glipizide Solid Lipid Nanoparticles

[0074] The prescription is as follows:

[0075] Glipizide 10 g

[0076] Trilaurin 120 g

[0077] Tween 80 68 g

[0078] Chitosan 32 g

[0079] The preparation method is as follows:

[0080] (a) Add 120 g of trilaurin to 500 mL of a mixed solution of ethanol and acetone with a volume ratio of 1:1, heat in a constant temperature water bath at 55°C, stir to dissolve, then add 10 g of glipizide, and stir Make it dissolve, constitute the organic phase, and set aside;

[0081] (b) Add 68 g of Tween (80) and 32 g of chitosan into 500 mL of purified water, heat in a constant temperature water bath at 55 °C, stir to dissolve, and form a water phase for later use;

[0082] (c) Under the condition of stirring at 800 rpm, slowly add the organic phase to the water phase, keep the temperature at 55 °C, and stir for 30 minutes;

[0083] (d) Concentrat...

Embodiment 3

[0099] Example 3 Preparation of Glipizide Lipid Nanoparticle Capsules

[0100] (1) Preparation of Glipizide Solid Lipid Nanoparticles

[0101] The prescription is as follows:

[0102] Glipizide 10 g

[0103] Trilaurin 160 g

[0104] Tween 80 90 g

[0105] Chitosan 20 g

[0106] The preparation method is as follows:

[0107] (a) Add 160 g of glycerol trilaurate into 500 mL of a mixed solution of ethanol and acetone with a volume ratio of 1:1, heat in a constant temperature water bath at 55°C, stir to dissolve, then add 10 g of glipizide, and stir Make it dissolve, constitute the organic phase, and set aside;

[0108] (b) Add 90 g of Tween (80) and 20 g of chitosan into 500 mL of purified water, heat in a constant temperature water bath at 55 °C, stir to dissolve, and form a water phase for later use;

[0109] (c) Under the condition of stirring at 800 rpm, slowly add the organic phase to the water phase, keep the temperature at 55 °C, and stir for 30 minutes;

[0110] (...

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Abstract

The invention relates to a new solid preparation of glipizide, in particular to a glipizide lipid nanoparticle solid preparation, and belongs to the technical field of medicine. According to the technical scheme, the glipizide lipid nanoparticle solid preparation compound is prepared from 2.5% of glipizide, 30-40% of water-insoluble lipid laurostearin, 5-8% of chitosan of which the molecular weight is 150-300 kDa, 17-22.5% of hydrophilic surfactant tween (80), 14-23% of lactose, 10-15% of starch, 3-5% of povidone (K30) and 1-1.5% of magnesium stearate. The glipizide lipid nanoparticle solid preparation has excellent performance.

Description

technical field [0001] The invention relates to a new solid preparation of glipizide, in particular to a solid preparation of lipid nanoparticles of glipizide, which belongs to the technical field of medicine. Background technique [0002] Type II diabetes belongs to non-insulin-dependent diabetes and is the main type of diabetes in my country. In the clinical treatment of type II diabetes, blood sugar control is the center and key point of treatment. Glipizide, as a second-generation sulfonylurea oral hypoglycemic drug, mainly achieves its rapid hypoglycemic effect by stimulating the pancreas to secrete insulin. At the same time, glipizide also has the effects of reducing triglyceride and cholesterol, increasing the ratio of high-density lipoprotein, promoting the inactivation of fibrinase, and inhibiting platelet aggregation. Hardening, etc. have a positive effect. [0003] Glipizide, chemical name 1-cyclohexyl-3-{4-[2-(5-methylpyrazine-2-amide)-ethyl]benzenesulfonyl}ur...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/14A61K47/36A61K47/26A61K47/32A61K9/20A61K9/48A61K31/64A61P3/10A61P9/10A61P3/06A61P7/02
CPCA61K9/145A61K9/146A61K9/1623A61K9/1635A61K9/1652A61K9/2018A61K9/2027A61K9/2059A61K31/64
Inventor 杨德斌周祥彪龙连清
Owner DISHA PHARMA GRP
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