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Stomatological drug preparation with slow-release effect and preparation method of stomatological drug preparation

A pharmaceutical preparation, oral technology, applied in the oral pharmaceutical preparation with sustained release effect and its preparation, the field of oral pharmaceutical preparation, can solve the problem that oral bactericidal drugs cannot obtain an ideal sustained release effect, etc., achieve inhibited growth and prolong release time Effect

Active Publication Date: 2018-05-08
GUANGZHOU LIBY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cyclodextrin and ethyl cellulose are the most commonly used drug-encapsulating carriers. Although they are widely used, they cannot actually achieve the desired sustained-release effect for oral antiseptic drugs.

Method used

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  • Stomatological drug preparation with slow-release effect and preparation method of stomatological drug preparation
  • Stomatological drug preparation with slow-release effect and preparation method of stomatological drug preparation
  • Stomatological drug preparation with slow-release effect and preparation method of stomatological drug preparation

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preparation example Construction

[0044] The preparation method of above-mentioned oral pharmaceutical preparation, comprises the following steps:

[0045] The ethanol solvent is used to dissolve and disperse 5-20 parts of the controlled-release agent, 60-90 parts of the forming agent and 5-20 parts of the bactericidal drug to obtain a sample stock solution with a mass fraction of 5%-20%.

[0046] And through the spray dryer, the parameters are set as follows:

[0047] Injection rate 10-40mL / min, air volume 50-70m 3 / h, atomization air pressure 0.1-0.2Mpa, air inlet temperature 140-160°C, needle pass frequency 60S, and powder particles were prepared.

Embodiment 1

[0050] A preparation method of an oral pharmaceutical preparation with sustained-release effect, comprising the following process steps:

[0051] Add 10 parts of cetylpyridinium chloride, 30 parts of triacetyl-β-cyclodextrin, 50 parts of ethyl cellulose, and 10 parts of stearic acid into the beaker, and add 75% ethanol solution, heat and stir at 40°C until Mix evenly to obtain a sample stock solution with a mass fraction of 10%, and pass it through a spray dryer. The parameters are set as follows: sample injection rate 10mL / min, air volume 60m 3 / h, atomization air pressure 0.1Mpa, air inlet temperature 140°C, needle pass frequency 60S, and powder particles with a particle size of 5 μm were prepared.

Embodiment 2

[0053] A preparation method of an oral pharmaceutical preparation with sustained-release effect, comprising the following process steps:

[0054] Add 15 parts of cetylpyridinium chloride, 75 parts of ethyl cellulose, and 10 parts of stearic acid into a beaker, and add 75% ethanol solution, heat at 40°C and stir until evenly mixed to obtain a sample with a mass fraction of 10% Stock solution, and through the spray dryer, the parameters are set as follows: injection rate 10mL / min, air volume 60m 3 / h, atomization air pressure 0.1Mpa, air inlet temperature 140°C, needle pass frequency 60S, and powder particles with a particle size of 5 μm were prepared.

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Abstract

The invention discloses a stomatological drug preparation with a slow-release effect. The stomatological drug preparation can be sustainably released within 8 hours, and still has an effective bacteriostatic effect within the 8 hours. The stomatological drug preparation is prepared from, by mass, 5-20 parts of release-controlled agent, 60-90 parts of shaping agent and 5-20 parts of bactericidal drug. It is accidentally discovered that the release time of the cationic bactericidal drug can be prolonged by adding a proper amount of release-controlled agent, drug loss caused by early rapid release of the drug is prevented, the drug release amount in the preceding one hour can be reduced to 1 / 6 time, and the subsequent sustainable release of the drug is ensured. The drug in the stomatologicaldrug preparation has the slow-release effect so that the breeding of oral bacteria can be inhibited for a longer time, that is, a long-acting bacteriostatic effect can be achieved.

Description

technical field [0001] The invention relates to an oral pharmaceutical preparation, which belongs to the technical field of medicine preparation, in particular to an oral pharmaceutical preparation with sustained release effect and a preparation method thereof. Background technique [0002] Modern medical research believes that the existence of bacteria is a prerequisite for the occurrence of oral diseases, and the pathogenicity of bacteria mainly depends on the existence of oral biofilm, that is, dental plaque. Dental plaque is a major factor in the inflammatory response of teeth and surrounding tissues, leading to two of the most common diseases of the oral cavity: dental caries and periodontal disease. Dental plaque has a complex bacterial group structure, its deep texture is dense, oxygen is scarce, and the acid formed is not easily diluted by saliva. Once the bacteria form a biofilm, the bacteria will gain a strong resistance that free bacteria do not have. [0003] Dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/12A61K47/14A61K9/16A61K31/44A61K31/155A61K31/14A61P1/02A61P31/04A61P31/02A61K8/36A61K8/37A61K8/49A61K8/43A61K8/41A61Q11/00A61Q17/00
CPCA61K8/361A61K8/37A61K8/375A61K8/416A61K8/43A61K8/4926A61K9/1617A61K31/14A61K31/155A61K31/44A61Q11/00A61Q17/005
Inventor 陈伟才易丹李淑钰刘亚军
Owner GUANGZHOU LIBY
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