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Clotrimazole ointment and preparation method thereof

A clotrimazole and cream technology, applied in the field of clotrimazole cream and preparation thereof, can solve the problems of reducing the absorption of clotrimazole, increasing the pain of patients, reducing the efficacy of medicine, etc., so as to reduce the pain of medication, improve the therapeutic effect, The effect of improving absorption efficiency

Inactive Publication Date: 2018-05-08
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing clotrimazole cream on the market has technical problems such as high drug concentration, greater skin irritation, low absorption and utilization rate of drug content, and low efficacy.
For example, the patent number is CN201210492020.6, and the patent name is a clotrimazole vaginal tablet and its preparation method. Clotrimazole is prepared into a tablet. The absorption of azoles will reduce the efficacy of the drug, and it will be very irritating to the affected area, which will increase the suffering of patients
Or the patent number is: CN200610109674.0, the patent name is clotrimazole gel and its preparation method, which is extremely difficult to clean after being applied to the affected area, and may easily cause secondary infection

Method used

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  • Clotrimazole ointment and preparation method thereof
  • Clotrimazole ointment and preparation method thereof
  • Clotrimazole ointment and preparation method thereof

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preparation example Construction

[0028] The present invention also provides a preparation method of clotrimazole cream, comprising the following steps;

[0029] S1, preparing the aqueous phase mixture;

[0030] The aqueous phase mixture is mixed with wetting agent and stabilizer after the thickener is foamed. Specifically, add purified water in the water phase stirring tank according to the proportion, so that the content of clotrimazole in the cream is 1-3%, and then add carbomer to soak for 12-14 hours, so that the carbomer is fully expanded and can Improve its thickening effect, then pump the carbomer after imbibition into the emulsification tank, add sorbitol and stir to dissolve, then add triethanolamine to continue stirring for 1-2h, heat to 70-80°C, and set aside. After the carbomer expands, it is first mixed with the wetting agent and then mixed with the stabilizer to ensure that the stabilizer can maintain the stability of the entire water phase mixture, to ensure the good effect of the carbomer and...

Embodiment 1

[0039] This embodiment provides a clotrimazole cream, which is mainly made of various raw materials, including 1kg clotrimazole, 4.6kg oil phase mixture, 7.8kg water phase mixture and 4kg dispersant. Wherein, 4.6kg of the oil phase mixture includes 2kg of stearic acid, 0.5kg of glyceryl monostearate, 1kg of Pingpingjia, 0.1kg of hydroxyphenethyl ester and 1kg of stearyl alcohol. The 7.8kg aqueous phase mixture includes 0.3kg carbomer, 7kg sorbitol and 0.5kg triethanolamine, and the dispersant is dimethyl sulfoxide.

[0040] The present invention also provides a method for preparing clotrimazole cream, comprising the following steps:

[0041] S1, preparing the aqueous phase mixture;

[0042] Get 83kg of purified water and put it into the water phase stirring tank (at this moment, the content of clotrimazole in the emulsifiable paste is 1%), add carbomer and soak for 12 hours, then pump the solution into the emulsification tank, add sorbitol and stir After dissolving, add trie...

Embodiment 2

[0050] This embodiment provides a clotrimazole cream, which is mainly made of various raw and auxiliary materials, including 3kg of clotrimazole, 4kg of oil phase mixture, 7kg of water phase mixture and 5kg of dispersant. Wherein, 4kg of the oily phase mixture includes 1.8kg of stearic acid, 0.4kg of glyceryl monostearate, 0.8kg of pingpingjia, 0.1kg of ethylparaben and 0.9kg of stearyl alcohol. The 7kg aqueous phase mixture includes 0.5kg carbomer, 6kg sorbitol and 0.5kg triethanolamine, and the dispersant is dimethyl sulfoxide.

[0051] The present invention also provides a method for preparing clotrimazole cream, comprising the following steps:

[0052] S1, preparing the aqueous phase mixture;

[0053] Get 81kg of purified water and put it into the water phase stirring tank (at this moment, the content of clotrimazole in the emulsifiable paste is 3%), add carbomer and soak for 13 hours, then pump the solution into the emulsification tank, add sorbitol and stir After disso...

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Abstract

The invention relates to the field of pharmacy, in particular to clotrimazole ointment and a preparation method thereof. The clotrimazole ointment is mainly prepared from various raw materials and auxiliary materials, wherein the various raw materials and auxiliary materials are prepared from 1 to 3 parts of clotrimazole, 4 to 5 parts of oil phase mixture, 7 to 9 parts of water phase mixture and 4to 6 parts of dispersing agent. The ointment is stable in characteristics, uniform and exquisite in matrix, low in irritation to the skin, good in tolerance, easy to clean, and capable of avoiding the secondary infection.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a clotrimazole cream and a preparation method thereof. Background technique [0002] Clotrimazole cream is an over-the-counter drug for gynecology. It is used for candidal vulvovaginal disease, especially for those with vaginal dryness or menopausal women who are inconvenient to use clotrimazole vaginal tablets. The existing clotrimazole cream on the market has technical problems such as high drug concentration, high skin irritation, low drug content absorption and utilization rate, and low drug efficacy. For example, the patent number is CN201210492020.6, and the patent name is a clotrimazole vaginal tablet and its preparation method. Clotrimazole is prepared into a tablet. The absorption of azole, then reduces drug effect, and it is very irritating to affected part, increases the misery of patient. Or the patent number is: CN200610109674.0, and the patent name is clotrimazole gel and...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/4174A61P15/02A61P31/10
CPCA61K31/4174A61K9/0014A61K9/06A61K47/44
Inventor 朱锋唐攀罗磊李林霞龙涛左娟王凤梅勇
Owner 重庆希尔安药业有限公司
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