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A kind of fat mesenchymal stem cell medicine and its preparation method and application

A technology of mesenchymal stem cells and drugs, applied in the field of adipose-derived mesenchymal stem cell drugs and its preparation, can solve the problems of increasing the risk of venous blood clots, ovarian cancer and breast cancer, and achieve strong targeting, high controllability, and promotion of functional The effect of ovulation

Active Publication Date: 2020-11-27
深圳市莱利赛生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One of the most common treatments for premature ovarian failure in women is hormone replacement therapy (HRT), but HRT can increase the risk of blood clots in the veins and ovarian and breast cancer.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] An adipose-derived mesenchymal stem cell drug, comprising: 8% adipose-derived mesenchymal stem cells, 6% follicle-stimulating hormone-secreting cells, 20% magnetic nano-sustained-release microspheres, 4% human serum albumin stock solution, 5% Coix seed oil, 1% flavonol glycosides, 1% vitamin E, 0.5% paclitaxel, 0.4% glutathione, 0.5% sodium hyaluronate, 0.3% phycocyanin, 0.4% zinc gluconate, 0.5% calcium heparin, 0.5% emulsifier, 0.5% stabilizer, 0.3% PH regulator, the balance is normal saline, the magnetic nano-sustained-release microspheres have a high loading rate, can release the drug effect slowly, and contain magnetism, which has stronger targeting; human blood Albumin stock solution can provide a suitable microenvironment for adipose-derived mesenchymal stem cells and follicle-stimulating hormone-secreting cells, and improve cell activity; coix seed oil has the effect of nourishing qi and nourishing yin, and can play a certain role in auxiliary conditioning; flavo...

Embodiment 2

[0035] A fat-derived mesenchymal stem cell drug, comprising: 10% fat-derived mesenchymal stem cells, 7% follicle-stimulating hormone-secreting cells, 21% magnetic nano-sustained-release microspheres, 5% human serum albumin stock solution, 6% Coix seed oil, 1.2% flavonol glycosides, 1.5% vitamin E, 0.8% paclitaxel, 0.6% glutathione, 1% sodium hyaluronate, 0.9% phycocyanin, 1.2% zinc gluconate, 0.6% calcium heparin, 0.7% emulsifier, 0.8% stabilizer, 0.4% PH regulator, the balance is normal saline, the magnetic nano-sustained-release microspheres have a high loading rate, can release the drug effect slowly, and contain magnetism, which has stronger targeting; human blood Albumin stock solution can provide a suitable microenvironment for adipose-derived mesenchymal stem cells and follicle-stimulating hormone-secreting cells, and improve cell activity; coix seed oil has the effect of nourishing qi and nourishing yin, and can play a certain role in auxiliary conditioning; flavonol gl...

Embodiment 3

[0048] An adipose-derived mesenchymal stem cell drug, comprising: 12% adipose-derived mesenchymal stem cells, 8% follicle-stimulating hormone-secreting cells, 22% magnetic nano-sustained-release microspheres, 6% human serum albumin stock solution, 7% Coix seed oil, 1.5% flavonol glycosides, 2% vitamin E, 1% paclitaxel, 0.8% glutathione, 1.5% sodium hyaluronate, 1.2% phycocyanin, 1.8% zinc gluconate, 0.8% heparin calcium, 1% emulsifier, 1% stabilizer, 0.5% PH regulator, the balance is normal saline, the magnetic nano-sustained-release microspheres have a high loading rate, can release the drug effect slowly, and contain magnetism, which has stronger targeting; human blood Albumin stock solution can provide a suitable microenvironment for adipose-derived mesenchymal stem cells and follicle-stimulating hormone-secreting cells, and improve cell activity; coix seed oil has the effect of nourishing qi and nourishing yin, and can play a certain role in auxiliary conditioning; flavonol...

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PUM

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Abstract

The invention discloses an application of adipose tissue-derived stromal cells in treating premature ovarian failure, and belongs to the technical field of a biological medicine. Adipose tissue-derived stromal cells and its excreted cell factors, and other components at a certain ratio are applied to form adipose tissue-derived stromal cells; then the adipose tissue-derived stromal cells are prepared to be injection fluid and a drug patch; the injection fluid is injected to the zone where a focus locates through a local target injection method, and then the patch is pasted to a patient's navel; through an electromagnetic impulse generator, a drug is intermittently stimulated, and the secretion of follicle-stimulating hormone is promoted, ovary endometrium can be effectively repaired, the functional ovulation is promoted, and premature ovarian failure is effectively treated. In short, the application has the advantages of being safe and effective, higher in controllability and strong inpracticability.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an adipose-derived mesenchymal stem cell drug and a preparation method and application thereof. Background technique [0002] Premature ovarian failure (POF), also known as hyperhormonal hypogonadism, refers to the occurrence of amenorrhea for 4-6 months in women before the age of 40. L) is associated with low estrogen secretion. POF can lead to loss of fertility and can also be linked to medical problems such as blood clots, osteoporosis, and heart disease. [0003] The causes of POF are complex. Some patients have ovarian abnormalities due to genetic diseases, such as fragile X (chromosome) syndrome, Turner syndrome, and certain autosomal gene mutations. Some cases of POF may be the result of an autoimmune disease. Chemotherapy and radiation therapy for cancer can also cause ovarian failure. There are two basic types of premature ovarian failure: one is that...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N5/071A61K35/28A61K38/38A61P15/08C12N5/0775A61K35/12A61K31/7048A61K31/785A61K31/315A61K38/06A61K36/8994A61K31/728A61K31/727A61K31/355A61K31/337
CPCA61K31/337A61K31/355A61K31/7048A61K31/727A61K31/728A61K31/785A61K33/30A61K35/12A61K35/28A61K36/8994A61K38/06A61K38/385C12N5/0667C12N5/0682C12N2506/1384A61K2300/00
Inventor 宋芸娟胡士庶张治国
Owner 深圳市莱利赛生物科技有限公司
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