Application of resuscitation solution obtaining rich hydrogen sulfide to preparation of medicine for treating hemorrhagic shock
A technology of resuscitation fluid and hydrogen sulfide, which is applied in the field of medicine, can solve problems such as ischemia-reperfusion injury, organ failure, and tissue perfusion insufficiency, and achieve the effects of improving microcirculation, protecting cardiomyocytes, and inhibiting cardiomyocyte damage
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Embodiment 1
[0031] Example 1: Preparation of resuscitation fluid rich in hydrogen sulfide
[0032] The first step, degassing treatment: put the 500mL physiological saline injection soft packaging bag in a low-pressure chamber, decompress at 0.4 absolute atmospheric pressure at room temperature for 2 hours, take it out and place it at room temperature and pressure for 4 hours, and remove the precipitated gas Withdraw with a syringe.
[0033] The second step, low-temperature pretreatment: place the above-mentioned degassed saline injection flexible packaging bag in an environment of 2° C. for 2 hours to fully cool under normal pressure.
[0034] Step 3, configure hydrogen sulfide solution: extract 50mL of physiological saline from the soft packaging bag after the above-mentioned low-temperature pretreatment, inject it into a closed container with solid sodium hydrogen sulfide 8.4mg (molecular weight 56), filter after fully dissolving, and The filtered hydrogen sulfide solution is injected ...
Embodiment 2
[0037] Embodiment 2: animal experiments
[0038] 1. Experimental animals: adult healthy Beagle dogs with a body weight of 12-15kg were purchased from the Experimental Animal Center of the Second Military Medical University.
[0039] Take 13 adult healthy Beagle dogs and divide them into 3 groups randomly:
[0040] Normal control group (Con), n=3;
[0041] Simple normal saline resuscitation group (NS), n=5;
[0042] Hydrogen sulfide-rich resuscitation fluid resuscitation group (H 2 S), n=5.
[0043] Except for the normal control group, hemorrhagic shock models were established in the other groups, and different resuscitation groups were given different resuscitation fluids for resuscitation after the hemorrhagic shock models were successfully established.
[0044] 2. Preparation of hemorrhagic shock model:
[0045] After the experimental dog was anesthetized with pentobarbital sodium, it was fixed on the operating table, and the left femoral artery, left jugular vein, and ...
Embodiment 3
[0093] Example 3: Preparation of resuscitation fluid rich in hydrogen sulfide
[0094] The first step, degassing treatment: place a 500mL physiological saline injection soft packaging bag in a low pressure chamber, decompress at room temperature at 0.8 absolute atmospheric pressure for 24 hours, take it out and place it at room temperature and pressure for 12 hours, and remove the precipitated gas Withdraw with a syringe.
[0095] The second step, low-temperature pretreatment: place the above-mentioned degassed saline injection flexible packaging bag in an environment of 0°C for 2 hours to fully cool under normal pressure.
[0096] The third step, configure the hydrogen sulfide solution: extract 50mL of physiological saline from the soft packaging bag after the above-mentioned low-temperature pretreatment, inject it into a closed container with 70 mg of solid sodium hydrogen sulfide (molecular weight 56), filter it after fully dissolving, and filter The final hydrogen sulfide...
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