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Composition containing algal polysaccharide sulfate, tablet and application of composition

A fucoidan and sulfate technology is applied in the directions of medical preparations containing active ingredients, pharmaceutical combinations, and non-active ingredients medical preparations, etc., to achieve the effects of moderate disintegration time limit, improved immunity, and stable dosage form quality.

Active Publication Date: 2018-04-13
北京颐方生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is currently no preparation of phycocyanin, fucoidan sulfate and seaweed powder, a preparation with stable quality and its preparation method, and its application in improving immunity. Therefore, a kind of phycocyanin, brown algae The preparation of polysaccharide sulfate ester and seaweed powder, the preparation with stable quality and its preparation method, as well as its application in aspects such as improving immunity have practical significance

Method used

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  • Composition containing algal polysaccharide sulfate, tablet and application of composition
  • Composition containing algal polysaccharide sulfate, tablet and application of composition
  • Composition containing algal polysaccharide sulfate, tablet and application of composition

Examples

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Effect test

Embodiment 1

[0040] Embodiment 1 A kind of composition containing fucoidan sulfate ester

[0041] This embodiment provides a tablet containing fucoidan sulfate, which is prepared by the following steps:

[0042] (1) Take 996g of fucoidan sulfate (average molecular weight: 40KDa), 900g of phycocyanin, 2904g of kelp powder, 60g of sodium alginate, 480g of sodium carboxymethyl starch, and 600g of microcrystalline cellulose, and dry at 60°C for 4 hours , over 120 mesh particles, spare.

[0043](2) Mix the dried fucoidan sulfate (the average molecular weight is 40KDa), phycocyanin and microcrystalline cellulose evenly. After the sodium carboxymethyl starch and sodium alginate are evenly mixed, they are evenly mixed with kelp powder in a dry state. Then continue to mix the two groups of mixed granules evenly, add 1200g of water as a binder, make soft materials, sieve and granulate the soft materials, dry the wet granules at 50°C, pass the dry granules through a 18-mesh sieve, and add magnesium...

Embodiment 2

[0044] Embodiment 2 A kind of composition containing fucoidan sulfate ester

[0045] This embodiment provides a tablet containing fucoidan sulfate, which is prepared by the following steps:

[0046] (1) Take 1200g of fucoidan sulfate (average molecular weight: 60KDa), 1080g of phycocyanin, 2640g of wakame powder, 60g of sodium alginate, 360g of corn starch, and 600g of microcrystalline cellulose, and dry them at 60°C for 4 hours. 120 mesh particles, spare.

[0047] (2) Mix the dried fucoidan sulfate (average molecular weight: 60KDa), phycocyanin and microcrystalline cellulose evenly. After the cornstarch and the sodium alginate are mixed evenly, they are evenly mixed with the wakame powder in a dry state. Continue to mix the two groups of mixed granules evenly, add 1200g of water as a binder, make soft materials, sieve and granulate the soft materials, dry the wet granules at 50°C, pass the dry granules through a 18-mesh sieve, and add calcium stearate 30g, 30g of magnesium...

Embodiment 3

[0048] Embodiment 3 A composition containing fucoidan sulfate

[0049] This example provides a chewable tablet containing fucoidan sulfate, which is prepared by the following steps:

[0050] (1) Take 996g of fucoidan sulfate (average molecular weight: 40KDa), 900g of phycocyanin, 2874g of kelp powder, 60g of sodium alginate, 480g of sodium carboxymethyl starch, and 600g of microcrystalline cellulose, and dry at 60°C for 4 hours , over 120 mesh particles, spare.

[0051] (2) Mix the dried fucoidan sulfate (the average molecular weight is 40KDa), phycocyanin and microcrystalline cellulose evenly. After the sodium carboxymethyl starch and sodium alginate are mixed evenly, they are evenly mixed with kelp powder and 30 g of mannitol in a dry state. Then continue to mix the two groups of mixed granules evenly, add 1200g of water as a binder, make soft materials, sieve and granulate the soft materials, dry the wet granules at 50°C, pass the dry granules through a 18-mesh sieve, and...

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Abstract

The invention relates to a composition containing algal polysaccharide sulfate, a tablet and an application of the composition to treatment of mesangial proliferative glomerulonephritis. The composition is prepared from, by weight, 10-25 parts of phycocyanin, 5-25 parts of algal polysaccharide sulfate, 30-60 parts of seaweed meal and 10-30 parts of excipients. The tablet prepared by the method isgreen to deep green, complete, bright, clean, uniform in color, less in weight difference, free from crack, moderate in disintegration time and stable in dosage form quality.

Description

technical field [0001] The invention relates to a composition containing fucoidan sulfate ester, a tablet and an application thereof, belonging to the technical field of medicine preparation. Background technique [0002] Some algae, including cyanobacteria, red algae, and microalgae that grow in freshwater, saltwater lakes, and seawater, contain about 10% phycobiliproteins, accounting for about 60% to 70% of the dry weight. Phycobiliproteins mainly include phycocyanin and isophycocyanin, and there are four types of phycoerythrin and phycoerythrin. The relative molecular mass of phycocyanin is about 246KDa, which is composed of α-subunit (peptide bond) with relative molecular mass of 18.5KDa and β-subunit (β-peptide bond) with relative molecular mass of about 40KDa. The α-subunit consists of 162 amino acids, and the β-subunit consists of 172 amino acids. There are 1 to 4 phycocyanin chromophores on each α-subunit and β-subunit, that is, phycocyanin is Combination of phycoc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/41A61K9/20A61K47/36A61K47/38A61K47/04A61K47/12A61P13/12A61P37/04A61K36/02A61K36/03A61K36/04A61K31/737
CPCA61K9/2009A61K9/2013A61K9/205A61K9/2054A61K9/2059A61K9/2095A61K31/737A61K36/02A61K36/03A61K36/04A61K38/41A61K2300/00
Inventor 石清东王姣陈赫岩王正元
Owner 北京颐方生物科技有限公司
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