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The application of erucamide in pharmaceuticals

An erucamide and drug technology, applied in the application field as an anti-sticking agent, can solve the problems of melting, uneven drying and wetness of particles, roughness, etc., and achieve the effect of solving the problem of sticking and punching, the surface is complete and smooth, and the machine of preventing sticking and punching is achieved.

Inactive Publication Date: 2012-02-22
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. Improper selection of lubricant or too little or uneven mixing
[0005] 2. The medicine is easy to absorb moisture, the dryness of the granules is not enough, too much water or the granules are unevenly dry and wet, resulting in stickiness
[0006] 3. The weather is humid, there is a small amount of water attached to the surface of the punch or the relative humidity in the room is too high, which is easy to cause sticking
[0007] 4. The surface of the punch is not clean, there is anti-rust oil or lubricating oil or the surface of the punch is rough
The amount of water-soluble lubricants such as PEG6000 should be controlled. It has certain hygroscopicity, which may affect the water content of the preparation and cause sticking. Also, stearic acid and PEG have a waxy texture, and the pressure is relatively large during the tableting process. Under the condition, there will be a phenomenon of melting, resulting in sticking or one-sided staining
In addition, some lubricants are expensive, use a lot, and the lubrication effect is not good, so there is an urgent need for an efficient and cheap lubricant to solve the problem

Method used

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  • The application of erucamide in pharmaceuticals
  • The application of erucamide in pharmaceuticals
  • The application of erucamide in pharmaceuticals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] No erucamide was added, and the original formula was tested. The ingredients of the formula are as follows:

[0033] Aminophylline 75g

[0034] Bromhexine Hydrochloride 15g

[0035] Chlorpheniramine Maleate 1.5g

[0036] Ethanol 17ml (95%)

[0037] Disodium hydrogen phosphate 3.6g

[0038] Talc powder 12g

[0039] Starch 29.4g

[0040] Magnesium stearate 1.2g

[0041] Hypromellose 6g

[0042] Sodium starch glycolate 2g

[0043] Starch slurry 3.6g

[0044] 1000 pieces (0.14g / piece)

[0045] The production process of tea cinnamin tablets:

[0046] (1) Prepare materials according to the above prescription, add chlorpheniramine maleate into 95% ethanol, stir until completely dissolved, add 2 / 3 of the recipe amount of starch and stir evenly, dry below 50°C, pass through a 80-mesh sieve, and set aside .

[0047] (2) Pulping: Dissolve disodium hydrogen phosphate in an appropriate amount of pure water and pour it into the pulping starch, add an appropriate amount of...

Embodiment 2

[0064] Remove the addition of lubricant talcum powder and magnesium stearate in the original formula, add erucamide 0.8g in the mixture, and the formula table is as follows:

[0065] Aminophylline 75g

[0066] Bromhexine Hydrochloride 15g

[0067] Chlorpheniramine Maleate 1.5g

[0068] Ethanol 17ml (95%)

[0069] Disodium hydrogen phosphate 3.6g

[0070] Starch 29.4g

[0071] Hypromellose 6g

[0072] Sodium starch glycolate 2g

[0073] Starch slurry 3.6g

[0074] Erucamide 0.8g

[0075] 1000 pieces (0.12g / piece)

[0076] The production process of tea pheniramine tablets: (1) prepare materials according to the above formula, add chlorpheniramine maleate to 95% ethanol, stir until fully dissolved, add 2 / 3 of the prescription amount of starch and stir evenly, 50 ℃ Dry the following, pass through 80 mesh sieves, and set aside.

[0077] (2) Pulping: Dissolve disodium hydrogen phosphate in an appropriate amount of pure water and pour it into the pulping starch, add an appr...

Embodiment 3

[0085] Remove the addition of lubricant talcum powder and magnesium stearate in the original formula, add erucamide 1.0g in the mixture, and the formula table is as follows:

[0086] Aminophylline 75g

[0087] Bromhexine Hydrochloride 15g

[0088] Chlorpheniramine Maleate 1.5g

[0089] Ethanol 17ml (95%)

[0090] Disodium hydrogen phosphate 3.6g

[0091] Starch 29.4g

[0092] Hypromellose 6g

[0093] Sodium starch glycolate 2g

[0094] Starch slurry 3.6g

[0095] Erucamide 1.0g

[0096] 1000 pieces (0.12g / piece)

[0097] Production technology is with embodiment 2.

[0098] According to the method of Example 1, 20 tablets of C batch of medicines were seized, and the measured average tablet weight was 0.1261g / sheet, and the quality inspection results were shown in the following table:

[0099]

[0100] According to the analysis of the results, among the 20 tablets of Batch C randomly selected and inspected, the appearance of the tablets was consistent, the surface w...

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Abstract

The invention belongs to the field of pharmaceutical preparations, discloses the application of erucamide in pharmacy, and in particular relates to the application of erucamide as an anti-adhesive granule in the process of tableting medicine. The present invention innovatively uses erucamide as a lubricant in the production of pharmaceuticals, only needs to add a small amount to achieve the lubricating effect, and can replace traditional lubricants for industrial production. Especially in the process of drug tableting, it can reduce the adhesion of the material to the die, prevent the sticking of the machine, solve the problem of sticking and punching in the process of drug tableting, keep the tablet uniform and complete, and meet the quality requirements of the tablet .

Description

Technical field: [0001] The invention belongs to the field of pharmaceutical preparations, and relates to the application of erucamide as a lubricant in pharmacy, in particular to the application of erucamide as an anti-adhesive granule in the process of compressing medicine into tablets. Background technique: [0002] The production process of pharmaceuticals mainly includes material preparation, granulation, drying, granulation, general mixing, tablet compression and packaging. The tableting process is the process of pressing the granules into tablets in a tablet machine. The extruded tablets generally require accurate content and small weight difference; the disintegration time limit or dissolution rate meets the regulations; the hardness is appropriate, the color is uniform, and the integrity is smooth; it must not deteriorate within the specified storage period and meet the hygiene inspection requirements, etc. However, in the tableting process, due to the influence of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C233/09A61J3/10B30B11/34
Inventor 黄和于文涛李晓菲郭成祥
Owner NANJING TECH UNIV
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