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a porous titanium

A technology of porous titanium and cavity, which is applied in the field of porous titanium for medical implant materials, can solve the problems of poor bone regeneration, insufficient growth of human bone tissue into implant materials, and inability to act as implant materials, so as to maintain normal physiological functions, Avoid damage and structural collapse, excellent performance

Active Publication Date: 2020-09-29
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, porous titanium is currently used as a medical implant material. In practical applications, the bone regeneration effect is not good. After it is implanted into the human body, the human bone tissue does not grow into the implant material enough, so it cannot be used as a real bone repair material.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The porous titanium of this embodiment is connected between the cavity and the cavity, and the cavity is also connected with the outside world. The cavity diameter of the porous titanium is 300 μm-600 μm, and the porosity is 96.9%. The preparation method is as follows:

[0018] (1) Take titanium hydride powder with a particle size of 400nm-600nm, urea powder with a particle size of 400μm-750μm, and rare earth Y with a particle size of 50nm-80nm 2 o 3 Powder, rare earth neodymium powder with a particle size of 50nm-80nm, titanium hydride powder, urea powder, rare earth Y 2 o 3 powder, rare earth neodymium powder according to weight ratio titanium hydride powder: urea powder: rare earth Y 2 o 3 Powder: Rare earth neodymium powder is mixed in a ratio of 150:1280:1:4, stirred repeatedly in the mixer for 2 hours, and pressed into a green body under a pressure of 100MPa by cold isostatic pressing equipment.

[0019] (2) Put the green body into the graphite mold, put the m...

Embodiment 2

[0031]The cavity of the porous titanium in this embodiment is connected with the cavity, and the cavity of the porous titanium is also connected with the outside world. The diameter of the cavity of the porous titanium is 300 μm-600 μm, and the porosity is 86%. The preparation method is similar Example 1, wherein the porosity and pore size are controlled by urea content and particle size, and the same method is tested with reference to Example 1, and the energy absorbed per unit volume of the porous titanium in this example is 1.6×10 when the strain reaches 50%. -3 J / mm 3 , The ratio of open porosity to porosity is 99.2%.

[0032] The dog implantation test was carried out with reference to the same method as in Example 1, and the porous titanium was implanted into the frontal bone. The results showed that there were no defects such as cracks and damage in the porous titanium after the operation, and the bone tissue grew into 78% of the pore volume of the porous titanium 12 we...

Embodiment 3

[0034] The cavity of the porous titanium in this embodiment is connected with the cavity, and the cavity of the porous titanium is also connected with the outside world. The diameter of the cavity of the porous titanium is 300 μm-600 μm, and the porosity is 81%. The preparation method is similar Embodiment 1, wherein porosity and pore size are controlled by urea content and particle size.

[0035] With reference to the same method test in Example 1, the energy absorbed per unit volume of the porous titanium in this example is 1.05×10 when the strain reaches 50%. -2 J / mm 3 , The ratio of open porosity to porosity is 98.8%.

[0036] The dog implantation test was carried out with reference to the same method as in Example 1, and the porous titanium was implanted into the thoracic vertebrae. The results showed that there were no defects such as cracks and damage in the porous titanium after the operation, and the bone tissue grew into 80% of the pore volume of the porous titanium...

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Abstract

The invention discloses medical porous titanium, wherein the material body of the porous titanium comprises pore cavities and cavity walls surrounding the pore cavities, the pore cavities are communicated to each other, the porosity of the porous titanium is not more than 97%, the porous titanium is at the plateau stress stage when the strain reaches 50%, and the absorption energy per unit volumeof the porous titanium is not less than 4.1*10< 4> J / mm<3> when the strain reaches 50%. According to the present invention, the medical porous titanium has good energy absorption capability, can meetthe needs of human bone tissue ingrowth, is used for bearing cancellous bone repair implants, and has good bone regeneration effect after implantation.

Description

technical field [0001] The invention relates to porous materials, in particular to a porous titanium used for medical implant materials. Background technique [0002] In the 21st century, the pace of human beings entering an aging society is accelerating, and the demand for biomedical implant materials is getting higher and higher. Among all biomedical implant materials, metal materials have become widely used human implant materials due to their excellent corrosion resistance, biocompatibility and high specific strength. The most common biomedical metal materials are stainless steel, Co-Cr alloy, titanium and titanium alloy. Compared with the former two, titanium and titanium alloy have the advantages of good biocompatibility, excellent comprehensive mechanical properties and strong corrosion resistance. Therefore, It has become a mainstream development product in the international community, and it is one of the most widely used artificial bone tissue repair or replacemen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/06A61L27/50B22F3/11
CPCA61L27/06A61L27/50A61L27/56A61L2430/02B22F3/001B22F3/1121
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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