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Polysaccharide-based hemostasis sponge with initiative hemostasis function as well as preparation process and application thereof

A technology of hemostatic sponge and polysaccharide, applied in the fields of application, pharmaceutical science, pharmaceutical formulation, etc., can solve the problem of no corresponding reports, shorten the coagulation time, improve the overall hemostatic performance, and promote the hemostasis of the liver and femoral artery. Effect

Inactive Publication Date: 2018-03-23
WENZHOU INST OF BIOMATERIALS & ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no corresponding report on the immobilization of organic polymers, especially specific peptides, and the improvement of their biosafety

Method used

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  • Polysaccharide-based hemostasis sponge with initiative hemostasis function as well as preparation process and application thereof
  • Polysaccharide-based hemostasis sponge with initiative hemostasis function as well as preparation process and application thereof
  • Polysaccharide-based hemostasis sponge with initiative hemostasis function as well as preparation process and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation method of the polysaccharide-based hemostatic sponge with active hemostatic function comprises the following steps:

[0034] (1) Disperse 20g of hydroxyethyl cellulose and chitosan (mass ratio: 1:1) in ultrapure water to form a suspension with a mass concentration of 5%, raise the temperature to 60°C, and react for 1 hour. Cool to room temperature. Wash 3 times with aqueous ethanol (the mass ratio of ethanol / water is 3 / 1), filter with suction, and dry under vacuum at room temperature.

[0035] (2) Disperse 10 g of the product obtained in (1) into dimethyl sulfoxide to prepare a suspension with a mass fraction of 1%. The suspension was warmed up to 80 °C and stirred for 1 h. Afterwards, cool to room temperature. To the resulting solution, add 1 g of trans-glycidyl methacrylate and react for 12 hours. Purify. The purification method is as follows: the obtained product is placed in a dialysis bag, dialyzed for 2 days, and then the obtained dialysate is...

Embodiment 2

[0039] The preparation method of the polysaccharide-based hemostatic sponge with active hemostatic function comprises the following steps:

[0040] (1) Disperse 20g of sodium alginate and cornstarch (mass ratio: 5:1) in ultrapure water, prepare a suspension with a mass concentration of 50%, heat up to 120°C, react for 5 hours, and cool to room temperature . Wash 5 times with ethanol aqueous solution (the mass ratio of ethanol / water is 3 / 10), filter with suction, and dry under vacuum at room temperature.

[0041] (2) Disperse 10 g of the product obtained in (1) into N,N-dimethylformamide to form a suspension with a mass fraction of 10%. The suspension was warmed up to 150°C and stirred for 3h. Afterwards, cool to room temperature. To the obtained solution, 5 g of acryloyl chloride was added, and reacted for 36 h. Purify. The purification method is as follows: the obtained product is placed in a dialysis bag, dialyzed for 7 days, and then the obtained dialysate is freeze-dr...

Embodiment 3

[0045] The preparation method of the polysaccharide-based hemostatic sponge with active hemostatic function comprises the following steps:

[0046] (1) Disperse 20g of chitosan and hyaluronic acid (mass ratio: 5:1) in ultrapure water to form a suspension with a mass concentration of 10%, heat up to 80°C, react for 2 hours, and cool to room temperature . Wash 4 times with aqueous ethanol (the mass ratio of ethanol / water is 3 / 5), filter with suction, and dry under vacuum at room temperature.

[0047] (2) Disperse 10 g of the product obtained in (1) into N,N-dimethylacetamide to prepare a suspension with a mass fraction of 5%. The suspension was warmed up to 100 °C and stirred for 2 h. Afterwards, cool to room temperature. To the resulting solution, add 2g of norbornene anhydride and react for 20h. Purify. The purification method is as follows: the obtained product is placed in a dialysis bag, dialyzed for 5 days, and then the obtained dialysate is freeze-dried to obtain the...

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Abstract

The invention discloses polysaccharide-based hemostasis sponge with an initiative hemostasis function as well as a preparation process and application thereof. The prepared hemostasis sponge can be used for bleeding and diffusive bleeding of a body surface and organs inside the body. When the polysaccharide-based hemostasis sponge contacts blood, an initial hemostasis method and a passive hemostasis method can be simultaneously adopted to accelerate the hemostasis process, and for different bleeding types, the hemostasis effect is significant. The polysaccharide-based hemostasis sponge has good biological compatibility and blood compatibility, excellent biological security, biodegradability and the like and has a promising clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of active hemostatic materials, and also relates to the field of biomedical polymer materials and biocompatibility modification. Permanent polysaccharide-based hemostatic sponge and its preparation process and application. Background technique [0002] In the first aid of sudden accidents, surgery and in war, 50% of the deaths are caused by massive bleeding. Some traditional hemostatic materials, such as hemostatic gauze, hemostatic bandage, hemostatic cotton yarn, etc., have limited hemostatic ability, and the hemostatic effect is not very satisfactory. Therefore, the development of highly efficient and quickly absorbable hemostatic materials and products, which can effectively stop bleeding within 1-2 minutes or even shorter after the bleeding occurs, has become one of the main goals of the research and development of hemostatic materials. [0003] Hemostatic materials can be roughly divided into activ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/10A61L24/00
CPCA61L24/0036A61L24/0042A61L24/08A61L24/108A61L2300/252A61L2300/418A61L2300/604A61L2400/04
Inventor 石长灿冯亚凯陈浩杨啸刘雯李娜席光辉
Owner WENZHOU INST OF BIOMATERIALS & ENG
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