Biological magnesium alloy containing nano magnesium oxide and nano silver and preparation method of biological magnesium alloy

Abstract

The invention relates to a biological magnesium alloy containing nano magnesium oxide and nano silver and a preparation method of the biological magnesium alloy. The biological magnesium alloy is prepared from nano magnesium oxide, nano silver and a degradable biological magnesium alloy matrix, wherein the nano magnesium oxide and nano silver contained are distributed on the crystal boundary of the matrix as a second phase; the nano magnesium oxide accounts for 4-6wt% of the biological magnesium alloy containing nano magnesium oxide and nano silver; the nano silver accounts for 0.03-0.08wt% ofthe biological magnesium alloy containing nano magnesium oxide and nano silver. The preparation method comprises the following steps: preparing nano MgO powder, nano Ag powder and degradable biological magnesium alloy matrix powder according to a set proportion, and putting into a ball mill; performing ball milling for 3-6 hours at a ball milling speed of 250-400rpm, in a protective atmosphere; preparing the biological magnesium alloy containing nano magnesium oxide and nano silver by a selective laser melting technology in a protective atmosphere.

Description

technical field [0001] The invention relates to a biological magnesium alloy containing nano magnesium oxide and nano silver and a preparation method thereof, belonging to the technical field of biological material design and preparation. Background technique [0002] An ideal bone graft should have good biocompatibility, biodegradability, and necessary functionality such as antibacterial properties. Compared with traditional biomedical metals such as stainless steel and titanium alloys, biomagnesium alloys have good biocompatibility, can be completely degraded and absorbed, have mechanical properties that match human bones, and have certain osteoinductive and osteoconductive capabilities. The field of bone grafting has received increasing attention. However, bacterial infection often occurs in wounds during bone grafting and repair, which can easily lead to failure of bone repair. Although the alkaline products degraded by biomagnesium alloys have certain antibacterial act...

AI Technical Summary

Problems solved by technology

As the most representative inorganic antibacterial material, nAg (nano-Ag) and its derivatives have broad-spectrum and high-efficiency antibacterial activity, but the biological toxicity of silver is very high, and a higher dosage will cause unpredictable risks to the human body; nMgO (Nano-MgO) has the advantages of broad-spectrum antibacterial properties, high thermal stability, and good biodegradability. More importantly, magnesium oxide is almost non-biologically toxic and has been certified by the U.S. Food and Drug Administration. However, The antibacterial activity of nMgO is low. For example, its minimum inhibitory concentration against Escherichia coli is usually 500-1000mg / L. At this concentration, the permeability of the cell membrane may change and reduce cell viability.

These factors limit their application as antimicrobial additives in biomagnesium alloys

At present, researchers have tried to coat micro-nano magnesium oxide and / or micro-nano silver on bio-magnesium alloys, but since micro-nano magnesium oxide and / or micro-nano silver exist in the form of coatings, Cause its antibacterial function to gradually disappear with the degradation of the coating

At the same time, due to the existence of micro-nano magnesium oxide and / or micro-nano silver in the form of coating, once it is not handled properly, there may be a risk of large-scale peeling off of the coating, especially during the degradation process, the probability of this risk is greatly increased