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Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and application thereof

A technology of cardiovascular and cerebrovascular diseases and compositions, which is applied in the field of medicine, can solve the problems of existing and increasing gastric damage in patients, and achieve the effects of reducing the volume rate, preventing the formation of thrombus, and reducing drug toxicity

Active Publication Date: 2018-03-06
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because aspirin has a greater loss to the stomach, it increases the risk of gastric damage in patients, especially for patients with a history of ulcers. Therefore, for long-term use of aspirin for antithrombotic therapy, the dosage is small to reduce damage to the stomach, but risk remains

Method used

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  • Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and application thereof
  • Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 American cockroach extract

[0030] Get the dry worm body of Periplaneta americana, add 8 times the volume fraction of the dry weight of the medicinal materials and be 75 parts of ethanol for cold soaking for 8 hours, then carry out the first reflux, and the reflux time is 2.5 hours; add the dry weight of the original medicinal materials to the medicinal residues 75 parts of ethanol of 6 times the amount of reflux for the second time, and the reflux time is 2 hours; continue to add 75 parts of ethanol of 6 times the amount of the original medicinal material dry weight in the medicinal residues and carry out the reflux for the third time, and the reflux time is 2 hours; The temperature is controlled at 70-80°C, the extracts obtained by reflux three times are combined, and the ethanol extract obtained by filtering through a 100-mesh sieve is slowly added to the double-effect concentrator for concentration without foaming, and the setting con...

Embodiment 2

[0031] The preparation of embodiment 2 salvia miltiorrhiza extract

[0032]Take the Danshen medicinal material, crush it, add water 12 times the weight of the original medicinal material, soak for 90 minutes, and then extract twice at 90°C, the first extraction time is 45 minutes, and the second extraction time is 60 minutes. The two extracts were combined and filtered. Add 95 parts of ethanol to the filtrate until the concentration of ethanol in the filtrate reaches 70 parts, let it stand for 8 hours, filter, concentrate the filtrate and recover ethanol, dry to obtain the salvia miltiorrhiza extract.

Embodiment 3

[0033] The preparation of embodiment 3 Rhizoma Chuanxiong extract

[0034] Take the Rhizoma Chuanxiong medicinal material, crush it, add 80 parts of ethanol that is 10 times the weight of the original medicinal material, soak for 2 hours, then heat and extract 3 times, the first extraction time is 1 hour, the second extraction time is 1.5 hours, and the third The extraction time is 2 hours. The three extracts were combined, filtered, concentrated under vacuum to a thick paste with a relative density of 1.10-1.25, recovered ethanol, and dried to obtain the Rhizoma Chuanxiong extract.

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Abstract

The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases. The pharmaceutical composition is composed of Periplaneta americana, aspirin and one or two selected from a group consisting of red sage roots and Rhizoma Chuanxiong. Specifically, the pharmaceutical composition comprises, by weight, 40 to 60 parts of Periplaneta americana, 20 to 50 partsof red sage roots and 5 to 20 parts of aspirin; or the pharmaceutical composition comprises, by weight, 40 to 60 parts of Periplaneta americana, 20 to 50 parts of Rhizoma Chuanxiong and 5 to 20 partsof aspirin; or the pharmaceutical composition comprises, by weight, 40 to 60 parts of Periplaneta americana, 15 to 25 parts of red sage roots, 15 to 25 parts of Rhizoma Chuanxiong and 5 to 20 parts ofaspirin. The pharmaceutical composition provided by the invention can effectively improve stomach damage caused by long-term taking of aspirin, effectively prevents formation of thrombus while reducing the dose of aspirin, lower the possibility of formation of cerebral infarction and reduces the drug toxicity of aspirin.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and its application. Background technique [0002] Cardiovascular and cerebrovascular diseases are collectively referred to as diseases of the heart and cerebrovascular diseases. It is also known as the "three highs" of "rich man's disease". Among the elderly over 60 years old, 40 to 45 suffer from high blood pressure and hyperglycemia or hyperlipidemia. According to the statistics of the Ministry of Health in 2007, according to foreign data, about 50 diabetics have combined A variety of geriatric diseases such as hypertension and hyperlipidemia. Cardiovascular and cerebrovascular diseases have the characteristics of "high morbidity, high disability rate, high mortality, high recurrence rate, and many complications", that is, "four highs and one high". At present, there are more than 270 mi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/236A61K36/537A61P9/00A61P9/10A61K31/616A61K35/64
CPCA61K31/616A61K35/63A61K36/236A61K36/537A61K2236/39A61K2236/333A61K2236/331A61K2300/00
Inventor 耿福能沈咏梅
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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