Culture medium for hericium erinaceus, biotransformation mycelium, extract of biotransformation mycelium and application of extract

A biotransformation, Hericium erinaceus technology, applied in microorganism-based methods, biochemical equipment and methods, microorganisms, etc., can solve problems such as adverse reactions, toxic and side effects, and achieve good hypoglycemic effects and anti-tumor effects.

Pending Publication Date: 2018-02-16
HUNAN XINHUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, insulin and chemically synthesized hypoglycemic drugs are commonly used in the treatment of diabetes, but there are many adverse reactions and side effects

Method used

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  • Culture medium for hericium erinaceus, biotransformation mycelium, extract of biotransformation mycelium and application of extract
  • Culture medium for hericium erinaceus, biotransformation mycelium, extract of biotransformation mycelium and application of extract
  • Culture medium for hericium erinaceus, biotransformation mycelium, extract of biotransformation mycelium and application of extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of extract of biotransformation mycelia, its preparation method comprises the steps:

[0027] (1) Take 490g of agricultural and sideline products wheat bran, 140g of corn flour, 70g of rice bran, and 300g of Chinese medicinal material Ligustrum lucidum powder (Ligustrum lucidum), mix well, add 400g of water and mix well, and obtain the culture medium of Hericium erinaceus bottle again, sterilize, insert Hericium erinaceus, transform and cultivate at 27°C for 40 days, take out the mycelium, and dry it to obtain the biotransformed mycelium;

[0028] (2) Take the biotransformed mycelium, soak it in water at 70° C. for 2 times, soak for 2 hours each time, the weight of the water is 6 times the weight of the biotransformed mycelium, and obtain the extract;

[0029] (3) Concentrate the extract obtained after extraction under reduced pressure, and vacuum-dry the concentrated solution obtained by concentrating under reduced pressure at 60° C. to obtain the extract of bio...

Embodiment 2

[0031] A kind of extract of biotransformation mycelia, its preparation method comprises the steps:

[0032] (1) Take 420g of agricultural and sideline products wheat bran, 120g of corn flour, 60g of rice bran, and 400g of Chinese medicinal material Ligustrum lucidum powder (Ligustrum lucidum), mix well, add 450g of water and mix well, and obtain the culture medium of Hericium erinaceus bottle again, sterilize, insert Hericium erinaceus, transform and cultivate at 20°C for 40 days, take out the mycelium, and dry it to obtain the biotransformed mycelium;

[0033] (2) Take the biotransformed mycelium, soak it in water at 60° C. for 3 times, each time for 3 hours, the weight of the water is 8 times the weight of the biotransformed mycelium, and obtain the extract;

[0034](3) Concentrate the extract obtained after extraction under reduced pressure, and vacuum-dry the concentrated solution obtained by concentrating under reduced pressure at 60° C. to obtain the extract of biotransf...

Embodiment 3

[0036] A kind of extract of biotransformation mycelia, its preparation method comprises the steps:

[0037] (1) Take 350g of agricultural and sideline products wheat bran, 100g of corn flour, 50g of rice bran, and 500g of Chinese medicinal material Ligustrum lucidum powder (Ligustrum lucidum), mix well, add 500g of water and mix well, and obtain the culture medium of Hericium erinaceus bottle again, sterilize, insert Hericium erinaceus, transform and cultivate at 25°C for 30 days, take out the mycelium, and dry it to obtain the biotransformed mycelium;

[0038] (2) Take the biotransformed mycelium, soak it in water at 50° C. for 3 times, soak for 5 hours each time, and the weight of the water is 10 times the weight of the biotransformed mycelium to obtain an extract;

[0039] (3) Concentrate the extract obtained after extraction under reduced pressure, and vacuum-dry the concentrated solution obtained by concentrating under reduced pressure at 60° C. to obtain the extract of b...

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Abstract

The invention discloses a culture medium for hericium erinaceus, biotransformation mycelium, an extract of biotransformation mycelium and an application of the extract. The culture medium for hericiumerinaceus is formed by adding traditional Chinese medicine fructus ligustri lucidi to basal culture media and comprises the basal culture media and fructus ligustri lucidi, wherein every 100 parts ofthe culture media comprises 50-70 parts of basal culture media and 30-50 parts of fructus ligustri lucidi; each basal culture medium is prepared from components in parts by weight as follows: 350-490parts of wheat bran, 100-140 parts of corn flour, 50-70 parts of bran and 400-500 parts of water. The biotransformation mycelium is a product obtained through mycelium transformation culture after the culture medium is inoculated with the hericium erinaceus. The extract of the biotransformation mycelium is prepared after hericium erinaceus mycelium is subjected to water extraction, reduced pressure condensation and final vacuum freeze drying. The extract of the biotransformation mycelium has a blood glucose reducing function which is superior to that of hericium erinaceus mycelium or fructusligustri lucidi and can be used for preparing a drug for reducing blood glucose.

Description

technical field [0001] The invention relates to the technical field of biopharmaceuticals, in particular to a culture medium of Hericium erinaceus, a biotransformation mycelium, an extract of the biotransformation mycelium and uses thereof. Background technique [0002] Hericium erinaceus, a mushroom (fungi) of the family Hericium erinaceae, has been used in traditional Chinese medicine to treat gastrointestinal diseases for more than 2,000 years. A series of small molecule compounds, such as erinacines, are believed to have nerve regeneration and can pass through The blood-brain barrier repairs damaged nervous tissue. Hericium erinaceus also has anti-ulcer, anti-inflammatory, anti-microbial, immune regulation, improving liver function, anti-aging, lowering blood sugar and blood lipids, improving anti-hypoxia ability, increasing cardiac output, and improving circulation, etc., including Hericium erinaceus The medical preparations of are widely used in China. [0003] The m...

Claims

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Application Information

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IPC IPC(8): C12N1/14A61K36/07A61P3/10C12R1/645
CPCC12N1/14A61K36/07
Inventor 何述金周代俊刘东艳
Owner HUNAN XINHUI PHARMA
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