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Preparation method of flexible liposomes

A technology of flexible liposomes and preparation steps, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., which can solve the problem of low transmittance of the stratum corneum of the skin, unstable chemical properties, and difficult skin absorption and other problems, to achieve the effect of improving the coating effect, good practicability, and high yield

Inactive Publication Date: 2018-02-09
SHAANXI EYOUNG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, domestic research in related fields is still in its infancy, and it is urgent to develop more liposome skin care products.
[0003] Vitamin E is a fat-soluble vitamin that can scavenge free radicals and delay skin photoaging. It is widely used in medicines and cosmetics, but its chemical properties are unstable, its water solubility is poor, and its transmittance through the stratum corneum of the skin is low. Not easily absorbed by the skin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation method of a kind of flexible liposome of the present invention, it comprises the following preparation steps:

[0018] (1) Take the following raw materials for use: lecithin, Beijing Shuangxuan Microbial Culture Medium Products Factory; cholesterol, Shanghai Sinopharm Group; sodium cholate, Aladdin Reagent Company; vitamin E, Aladdin Reagent Company; polyethylene glycol, Tianjin Fuyu Fine Chemical Co., Ltd.;

[0019] (2) Quantitatively weigh egg yolk lecithin, cholesterol, sodium cholate and vitamin E, add them into a round bottom flask, add 20 ml of chloroform-methanol complex solvent to dissolve, and put them in a water bath at 35-68°C by vacuum Water pump, negative pressure rotary evaporation to remove organic solvent until a dark yellow uniform film appears on the wall of the flask;

[0020] (3) Add 20 mL of phosphate buffer saline containing 2% polyethylene glycol, and wash the membrane at 40 °C for 1 h;

[0021] (4) Moderately sonicate in an ice-...

Embodiment 2

[0024] The preparation method of a kind of flexible liposome of the present invention, it comprises the following preparation steps:

[0025] (1) Take the following raw materials for use: lecithin, Beijing Shuangxuan Microbial Culture Medium Products Factory; cholesterol, Shanghai Sinopharm Group; sodium cholate, Aladdin Reagent Company; vitamin E, Aladdin Reagent Company; polyethylene glycol, Tianjin Fuyu Fine Chemical Co., Ltd.;

[0026] (2) Quantitatively weigh egg yolk lecithin, cholesterol, sodium cholate and vitamin E, add them into a round bottom flask, add 20 ml of chloroform-methanol complex solvent to dissolve, and put them in a water bath at 35-68°C by vacuum Water pump, negative pressure rotary evaporation to remove organic solvent until a dark yellow uniform film appears on the wall of the flask;

[0027] (3) Add 20 mL of phosphate buffer saline containing 2% polyethylene glycol, and wash the membrane at 40 °C for 1 h;

[0028] (4) Moderately sonicate in an ice-...

Embodiment 3

[0032] The preparation method of a kind of flexible liposome of the present invention, it comprises the following preparation steps:

[0033] (1) Take the following raw materials for use: lecithin, Beijing Shuangxuan Microbial Culture Medium Products Factory; cholesterol, Shanghai Sinopharm Group; sodium cholate, Aladdin Reagent Company; vitamin E, Aladdin Reagent Company; polyethylene glycol, Tianjin Fuyu Fine Chemical Co., Ltd.;

[0034] (2) Quantitatively weigh egg yolk lecithin, cholesterol, sodium cholate, and vitamin E, add them to a round bottom flask, add 20 ml of chloroform-methanol complex solvent to dissolve, and put them in a water bath at 35-68°C under vacuum Water pump, negative pressure rotary evaporation to remove organic solvent until a dark yellow uniform film appears on the wall of the flask;

[0035] (3) Add 20 mL of phosphate buffer saline containing 2% polyethylene glycol, and wash the membrane at 40 °C for 1 h;

[0036] (4) Moderately sonicate in an ic...

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PUM

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Abstract

The invention relates to a preparation method of flexible liposome, which comprises the following preparation steps: taking the following raw materials for use: lecithin, Beijing Shuangxuan Microbial Culture Medium Products Factory; cholesterol, Shanghai Sinopharm Group; sodium cholate, Aladdin Reagent Company Vitamin E, Aladdin Reagent Company; Polyethylene glycol, Tianjin Fuyu Fine Chemical Co., Ltd.; The preparation method of flexible liposome of the present invention, by improving the deformability of liposome, thereby improves coating effect, It has good yield and good practicability.

Description

technical field [0001] The invention relates to a preparation method of a flexible liposome. Background technique [0002] Since Dior and others developed the first liposome cosmetic called Capture in 1986, liposome technology has been gradually applied to the field of skin care cosmetics. In recent years, with the improvement of people's living standards in our country, more and more liposome cosmetics have been introduced into the country. However, domestic research in related fields is still in its infancy, and more liposome skin care products need to be developed urgently. [0003] Vitamin E is a fat-soluble vitamin that can scavenge free radicals and delay skin photoaging. It is widely used in medicines and cosmetics, but its chemical properties are unstable, its water solubility is poor, and its transmittance through the stratum corneum of the skin is low. Not easily absorbed by the skin. Liposome, also known as transfer body, as a nano-drug carrier, can effectively...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/55A61K8/63A61K8/67A61K8/86A61Q19/08
CPCA61K8/14A61K8/553A61K8/63A61K8/678A61K8/86A61K2800/522A61Q19/08
Inventor 张俊
Owner SHAANXI EYOUNG TECH
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