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Method and system for effective breath-synchronized delivery of medicament to the lungs

A liquid drug and breath detection technology, which is applied in the direction of drug devices, respirators, nebulizers for treatment, etc., can solve the problems of long delay of surfactant, time-consuming, long time of drug pressure rise, etc., to achieve hygienic and Safe handling, low cost effect

Inactive Publication Date: 2018-02-06
CHIESI FARM SPA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 1) When the infusion pump is activated, the drug pressure rise time is long, resulting in a long delay from when the volumetric pump starts to when the surfactant flows at the end of the catheter
[0010] 2) Rapid detection of the respiratory phase needed to synchronize surfactant delivery in the respiratory phase is prevented since the respiratory signal can be delayed and masked by motor activation
High airflows, such as airflows above 1.5 liters per minute (LPM), are not compatible with the system, so this solution cannot be implemented
[0023] 2) Reduce the compliance of the system
Unfortunately, this process is very time consuming and it is difficult to completely remove air bubbles from the system
In addition, the outcome of the infusion process is unpredictable, making it difficult to determine the operating conditions of the system
[0024] Both of the adjustment solutions proposed above are quite time-consuming and cannot completely solve the problem

Method used

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  • Method and system for effective breath-synchronized delivery of medicament to the lungs
  • Method and system for effective breath-synchronized delivery of medicament to the lungs
  • Method and system for effective breath-synchronized delivery of medicament to the lungs

Examples

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specific Embodiment approach

[0061] Referring to the drawings, there are shown implementations of methods and systems according to preferred embodiments of the present invention. In the examples discussed herein, the problem of delivering the correct amount of aerosolized drug to a patient is dealt with: specifically, administering pulmonary surfactant to, eg, premature neonates. The pulmonary surfactant used was alpha phosphate, formulated as an 80 mg / ml aqueous suspension and commercially available from Chiesi Farmaceutici SpA.

[0062] However, any pulmonary surfactant currently used or later proposed for use in the respiratory distress system and other pulmonary conditions may be suitable for use in the present invention. These include modified natural, artificial and reconstituted pulmonary surfactants (PS).

[0063] Current modified natural lung surfactants include, but are not limited to: bovine lipid lung surfactant (BLESTM, BLES Biochemicals Inc., London, Ontario), calfactant (InfasurfTM, Forest...

Embodiment 2

[0171] A possible way to detect breathing phases is Figure 12 The method shown in:

[0172] The P measurement is the sum of the surfactant flow generated by intermittent activation of the infusion pump plus the pharyngeal pressure generated by spontaneous breathing activity. Due to the high hydrodynamic resistance of the nebulizing catheter to the flow of surfactant, the pressure generated by infusion pump activation is usually much higher than the pressure generated by respiratory activity (in some embodiments, it can be as high as 10 times).

[0173] Example 2 is based on the consideration that the respiratory activity recorded on the pressure signal on the surfactant line during motor startup may be masked by the pressure drop caused by the surfactant flow, whereas, when the infusion pump is inactive, the respiratory activity Signals are easily detected. Therefore, pump activation is initiated by detecting the onset of inspiration on the surfactant line (eg, cessation o...

Embodiment 3

[0209] Example 3 discloses a solution that allows detection of the end of inspiration and the end of expiration.

[0210] Example 3: Reconstructing the entire breathing signal

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Abstract

The method and system according to preferred embodiments of the present invention allows an effective breath-synchronized delivery of atomized liquid medicament (e.g. a pulmonary surfactant) to the patient's lungs. According to a preferred embodiment, the method of the present invention provides an efficient delivery of the aerosol medicament, controlling the behavior of the infusion pump to makethe rising and falling time faster even though the intrinsic time constant of the system is long. Additionally, in an embodiment of the present invention, at the same time the information about the breathing activity contained either directly on the surfactant line or stored in the controller action can be used to extrapolate the breathing pattern.

Description

technical field [0001] The present invention relates to the field of retropharyngeal infusion of drugs, in particular, the present invention relates to methods and systems for administering pulmonary surfactants by aerosolization and respiratory / synchronous delivery. Background technique [0002] Premature infants are prone to develop IRDS (Infant Respiratory Distress Syndrome) due to extensive lung immaturity. Currently, the clinical management of RDS in preterm infants mainly relies on: 1) providing respiratory support; and 2) administering exogenous pulmonary surfactant. At present, the most widely accepted method of providing respiratory support for newborns is to avoid invasive mechanical ventilation and intubation, and to use non-invasive respiratory support methods, such as nasal continuous positive airway pressure (CPAP), nasal intermittent positive pressure ventilation ( NIPPV) or high-flow nasal cannula (HFNC), as long as mechanical ventilation is not absolutely n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M15/08A61M16/04A61M16/08A61M16/14A61B5/087A61B5/03
CPCA61B5/037A61B5/087A61B5/6852A61B2562/0247A61M15/009A61M15/08A61M16/0051A61M16/0057A61M16/0461A61M16/14A61M2016/0021A61M2016/0027A61M2202/0488A61M2205/50A61M2205/502A61M16/0866A61M16/0072A61M16/0808A61M11/007A61M16/026A61M2205/3317A61M2205/52A61M2240/00
Inventor R·德拉卡I·米莱西
Owner CHIESI FARM SPA
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