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A kind of preparation method of selenized sodium alginate hydrogel

A technology of sodium alginate and alginic acid is applied in the field of preparation of selenium-enriched organic compounds, which can solve the problems of chemical cross-linking agents with large toxic and side effects, difficult to remove cross-linking agents, poor hydrogel performance, etc., and achieves high environmental friendliness. , High mechanical strength, good for observation and monitoring

Active Publication Date: 2020-07-14
河南省乡振农村创业服务有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The above-mentioned patents have complicated process, high energy consumption, pollution and hazards of the reaction raw materials, and the chemical cross-linking agent used in the reaction process has high toxicity and side effects. Poor prospects and other defects

Method used

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  • A kind of preparation method of selenized sodium alginate hydrogel
  • A kind of preparation method of selenized sodium alginate hydrogel
  • A kind of preparation method of selenized sodium alginate hydrogel

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Embodiment 1

[0031] A kind of preparation method of selenized sodium alginate hydrogel proposed by the present invention comprises the following steps:

[0032] S1. Preparation of alginic acid pre-crosslinked product:

[0033] Add 10.8g of alginic acid into 65g of epichlorohydrin, stir and dissolve until uniformly dispersed, then raise the temperature and reflux for 4 hours. After the reaction is completed, use a rotary evaporator to evaporate the solvent in the reaction system to dryness to obtain a pre-crosslinked alginic acid 14.6g;

[0034] S2, preparation of selenized alginic acid:

[0035] Dissolve the alginic acid pre-crosslinked product obtained in step S1 in 100ml of dichloromethane, add 0.54g of solid sodium hydroxide, slowly add 54g of a 10% sodium diselenide aqueous solution dropwise at room temperature while stirring, and stir After reacting for 4 hours to obtain a reaction product, the obtained reaction product was washed twice with 200 ml of deionized water and then evapor...

Embodiment 2

[0039] A kind of preparation method of selenized sodium alginate hydrogel proposed by the present invention comprises the following steps:

[0040] S1. Preparation of alginic acid pre-crosslinked product:

[0041] Add 10.9g of alginic acid to 76.3g of methyl epichlorohydrin, stir and dissolve until uniformly dispersed, then raise the temperature and reflux for 4 hours. After the reaction is completed, use a rotary evaporator to evaporate the solvent in the reaction system to dryness to obtain alginic acid pre- Cross-linked product 15.8g;

[0042] S2, preparation of selenized alginic acid:

[0043] Dissolve the alginic acid pre-crosslinked product obtained in step S1 in 100 ml of ethyl acetate, add 0.68 g of SDS, slowly add 108 g of 10% sodium diselenide aqueous solution dropwise at room temperature while stirring, and stir for 4 hours to obtain a reaction product, the resulting reaction product was washed twice with 200ml deionized water and then evaporated to dryness to obt...

Embodiment 3

[0047] A kind of preparation method of selenized sodium alginate hydrogel proposed by the present invention comprises the following steps:

[0048] S1. Preparation of alginic acid pre-crosslinked product:

[0049] Add 10.6g of alginic acid to 84.8g of epichlorohydrin, stir and dissolve until uniformly dispersed, then raise the temperature and reflux for 4 hours. After the reaction is completed, use a rotary evaporator to evaporate the solvent in the reaction system to dryness to obtain alginic acid pre-crosslinked 14.9g;

[0050] S2, preparation of selenized alginic acid:

[0051] Add the alginic acid pre-crosslinked product obtained in step S1 and dissolve it in 100ml of chloroform, add 1.08g of sodium cetyl sulfate, and slowly add 160g of a 10% sodium diselenide aqueous solution dropwise at room temperature while stirring, Stirring and reacting for 4 hours to obtain a reaction product, the obtained reaction product was washed twice with 200 ml of deionized water and then eva...

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Abstract

The invention discloses a preparation method of selenide sodium alginate hydrogel. The method comprises the following steps: adding alginic acid into an activating agent; stirring and dissolving; thenincreasing the temperature and reflowing; drying the solvent by distillation after the reaction is finished, so as to obtain an alginic acid pre-crosslinked substance; dissolving the alginic acid pre-crosslinked substance into a reaction agent; adding a catalyst and a sodium diselenide water solution; stirring and reacting; washing twice with deionized water; drying by distillation to obtain selenide alginic acid; adding the selenide alginic acid into water; dropwise adding a sodium hydroxide water solution; stirring and dissolving; then packing; and performing light crosslinking treatment, thus obtaining the selenide sodium alginate hydrogel. The preparation method is simple in processes and low in energy consumption, and the raw materials are low in price and easy to obtain; the naturalproduct, namely, alginic acid, is used as the main raw material, and is nontoxic, harmless, high in biocompatibility, environmentally friendly, and applicable to industrial production; the prepared hydrogel is high in biocompatibility, high in mechanical intensity, high in transparence, beneficial for observing and monitoring, and worthy of popularization.

Description

technical field [0001] The invention relates to the technical field of preparation of selenium-rich organic matter, in particular to a preparation method of selenized sodium alginate hydrogel. Background technique [0002] Selenium is an essential trace element for humans and animals. It is a component of erythrocyte glutathione peroxidase. Its main function is to participate in the synthesis of enzymes and protect the structure and function of cell membranes from excessive oxidation and interference. It has the functions of anti-cancer, anti-cancer, heart protection, cataract prevention, prevention and treatment of Keshan disease, Kashin-Beck disease and anti-aging. It also has detoxification effect on some heavy metal elements (such as lead, arsenic, cadmium, mercury, etc.). Sodium alginate is a natural polysaccharide contained in a large amount in seaweed, and is currently widely used in dressings for food and medicine. The use of epichlorohydrin to modify sodium alginat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/24C08B37/04C08L5/04
Inventor 李志军那日松张占平董万红
Owner 河南省乡振农村创业服务有限公司
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