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Poly-citrate prepolymer/chitin nano crystal whisker slurry and preparation method of same

A chitin nanocrystal and polycitrate technology, which is used in prosthesis, medical science, additive processing, etc., can solve the problem that polycitrate cannot be directly 3D printed, and achieves a simple method and improves mechanical properties. Effect

Inactive Publication Date: 2018-01-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the problem that polycitrate in the prior art cannot directly carry out 3D printing, provide a kind of polycitrate prepolymer / chitin nano-whisker slurry that can be applied to 3D printing technology and its Preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation method of polycitrate prepolymer / chitin nano whisker slurry, the steps are as follows:

[0034] (1) Disperse chitin nano-whiskers in deionized water to form a dispersion liquid. Chitin nano-whiskers are needle-shaped nanoparticles obtained by hydrolyzing chitin extracted from shrimp and crab shells with hydrochloric acid. Chitin nano-crystals The average length of whiskers is 300nm, and the average diameter is 20nm;

[0035] (2) Mix citric acid with 1,8-octanediol and polyethylene glycol at a molar ratio of 1:0.3:0.7, melt at 155°C, react at 135°C for 2 hours, dialyze with deionized water, and freeze-dry to remove Moisture content obtains polycitrate prepolymer, joins in the dispersion liquid of step (1) and obtains the mixture solution that solid content is 10%, wherein the mass ratio of chitin nano-whiskers and polycitrate prepolymer is 0.25 :1;

[0036] (3) Carry out vacuum freeze-drying treatment in a vacuum freeze dryer, the drying conditions are:...

Embodiment 2

[0040] The preparation method of polycitrate prepolymer / chitin nano whisker slurry, the steps are as follows:

[0041] (1) Disperse chitin nano-whiskers in PBS buffer solution with a pH value of 7.4 to form a dispersion liquid. Chitin nano-whiskers are needle-like nano-whiskers obtained by hydrolyzing chitin extracted from shrimp and crab shells with hydrochloric acid. Particles, chitin nano whiskers have an average length of 300nm and an average diameter of 20nm;

[0042](2) Mix citric acid and tri-block polyether in a molar ratio of 1.5:1, melt at 157°C, react at 145°C for 12 hours, dialyze with deionized water, freeze-dry to remove water to obtain polycitrate Polymer, being added to the dispersion liquid of step (1) to obtain a mixture solution with a solid content of 7%, wherein the mass ratio of chitin nano whiskers and polycitrate prepolymer is 0.35:1;

[0043] (3) Carry out vacuum freeze-drying treatment in a vacuum freeze dryer, the drying conditions are: temperature ...

Embodiment 3

[0047] The preparation method of polycitrate prepolymer / chitin nano whisker slurry, the steps are as follows:

[0048] (1) Disperse chitin nano whiskers in a PBS buffer solution with a pH value of 5.0 to form a dispersion. Particles, chitin nano whiskers have an average length of 300nm and an average diameter of 20nm;

[0049] (2) Mix citric acid with 1,8-octanediol and tri-block polyether at a molar ratio of 1:0.7:0.3, melt at 160°C, react at 125°C for 8 hours, dialyze with deionized water, and freeze-dry Remove water content and obtain polycitrate prepolymer, join in the dispersion liquid of step (1) and obtain the mixture solution that solid content is 5%, wherein the mass ratio of chitin nano-whiskers and polycitrate prepolymer is 0.8:1;

[0050] (3) Carry out vacuum freeze-drying treatment in a vacuum freeze dryer, the drying conditions are: temperature -70°C, pressure 5Pa, time 12h;

[0051] (4) Adding PBS buffer solution with a pH value of 5.0 and mixing to obtain a ...

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Abstract

The invention relates to poly-citrate prepolymer / chitin nano crystal whisker slurry and a preparation method of same. The preparation method includes the following steps: 1) dispersing chitin nano crystal whiskers in a solvent to obtain a dispersant; 2) adding a poly-citrate prepolymer to obtain a mixture solution; 3) performing vacuum freeze drying; 4) adding a solvent with mixing to obtain the poly-citrate prepolymer / chitin nano crystal whisker slurry. During preparation, the solvent can not only cause self-emulsification of the poly-citrate prepolymer but also disperse the chitin nano crystal whiskers. The preparation method is simple. In the slurry, the chitin nano crystal whiskers are adhered to the surfaces of emulsion particles formed by the poly-citrate prepolymer through electrostatic attraction effect, thus assembling a three-dimensional crosslinked network structure. The slurry has characters of non-Newtonian fluids, such as shear thinning, and also shows stress yield duringa dynamic rheologic test. The slurry can be used for producing a porous tissue engineering scaffold as a 3D printing raw material and has great industrial production value.

Description

technical field [0001] The invention belongs to the field of tissue engineering scaffolds for soft tissue repair, in particular to a polycitrate prepolymer / chitin nano-whisker slurry and a preparation method thereof. Background technique [0002] An ideal tissue engineering scaffold should imitate the natural interstitium to the greatest extent in terms of function and structure, and provide a temporary place for cell proliferation and regeneration of new interstitial cells. Different tissues and organs of the human body have different requirements for the mechanical properties, degradation rate, pore size and porosity of tissue porous scaffolds. [0003] At present, the methods used to prepare porous tissue scaffolds mainly include particle leaching, gas foaming, phase separation / freeze drying, electrospinning, and rapid prototyping. Rapid prototyping, that is, 3D printing, mainly uses the principle of discrete stacking to design a model through 3D CAD, and then converts 3...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/58C08G63/668B33Y70/00A61L27/20A61L27/18
Inventor 吉亚丽田雅玲梁凯杨庆郯志清郭永芳
Owner DONGHUA UNIV
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