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VC transdermal patch and preparation method thereof

A transdermal patch and penetrating agent technology, applied in the field of transdermal patches, can solve problems such as strong adhesion and poor adhesion, and achieve good stability, long drug action time, and good biocompatibility Effect

Inactive Publication Date: 2018-01-19
厦门蔚扬药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For transdermal patches, it can be divided into two types. One kind contains no water or low amount of water. The matrix is ​​mainly rubber, silicone glue, polyisobutylene and acrylic resin. strong, more prone to skin irritation; the other is mainly a water-containing gel-type transdermal patch, and its matrix is ​​mainly polymer materials such as polyacrylic acid, carbomer, cellulose, gelatin, etc., and its skin irritation is non-toxic. or small, but poor adhesion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Add 1000ml of 60% ethanol to 100g of HPMC-E4 to swell overnight, and filter to obtain a clear solution. CMC-Na 40g plus 400ml water swelling overnight.

[0033] (2) Add CMC-Na solution into HPMC solution, then add dropwise 30ml of azone, 90ml of glycerin, 80ml of Tween-80 and mix well.

[0034] (3) 150g of vitamin C was dissolved in 1000ml of water at 45°C, and slowly added to the HPMC solution to make it into a glue with a certain consistency.

[0035] (4) Ultrasonic defoaming, let it stand for half an hour, and apply it on a glass plate.

[0036] (5) Keep observing the film formation in a 50°C oven and start the film.

Embodiment 2

[0038] (1) Add 100 g of carbomer to 1000 ml of 60% ethanol to swell overnight, and filter to obtain a clear solution. CMC-Na 40g plus 400ml water swelling overnight.

[0039] (2) Add CMC-Na solution into HPMC solution, then add dropwise 30ml of azone, 90ml of glycerin, 80ml of Tween-80 and mix well.

[0040] (3) 150g of vitamin C was dissolved in 1000ml of water at 45°C, and slowly added to the HPMC solution to make it into a glue with a certain consistency.

[0041] (4) Ultrasonic defoaming, let it stand for half an hour, and apply it on a glass plate.

[0042] (5) Keep observing the film formation in a 50°C oven and start the film.

Embodiment 3

[0044] (1) Add 100 g of polyvinyl alcohol to 1000 ml of 60% ethanol to swell overnight, and filter to obtain a clear solution. CMC-Na 40g plus 400ml water swelling overnight.

[0045] (2) Add CMC-Na solution into HPMC solution, then add dropwise 30ml of azone, 90ml of glycerin, 80ml of Tween-80 and mix well.

[0046] (3) 150g of vitamin C was dissolved in 1000ml of water at 45°C, and slowly added to the HPMC solution to make it into a glue with a certain consistency.

[0047] (4) Ultrasonic defoaming, let it stand for half an hour, and apply it on a glass plate.

[0048] (5) Keep observing the film formation in a 50°C oven and start the film.

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PUM

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Abstract

The invention relates to a VC transdermal patch and a preparation method of the VC transdermal patch. The VC transdermal patch is mainly composed of a substrate, a permeation promoter, a plasticizer and a main medicine, and is characterized in that the substrate is one or the combination of two of the following components: hydroxypropyl methylcellulose, carbomer, polyvinyl alcohol and sodium carboxymethyl cellulose; the permeation promoter is one or the combination of two of the following components: propylene glycol, azone, dimethyl sulofoxide and peppermint oil; the plasticizer is one or thecombination of two of the following components: propylene glycol, glycerol and polyethylene glycol. The VC transdermal patch provided by the invention is good in bioavailability, the medicine can release efficiently, and the use is safe, reliable and convenient. The invention aims at providing the VC transdermal patch and the preparation method of the VC transdermal patch, the preparation processis simple, the stability is good, and the large-scale industrial production can be easily realized.

Description

technical field [0001] The present invention relates to V C A transdermal patch and a preparation method thereof belong to the field of transdermal patches, and specifically relate to the prevention and treatment of scurvy and a preparation method thereof. Background technique [0002] Vitamin C (Vitamin C, Ascorbic Acid), also known as L-ascorbic acid, is a water-soluble vitamin that is abundant in fruits and vegetables. It plays a regulatory role in redox metabolic reactions, and its lack can cause scurvy. In addition, vitamin C also participates in the synthesis of collagen, prevents gingival atrophy and bleeding, prevents arteriosclerosis, treats anemia, prevents cancer, and improves human immunity. At present, there are many dosage forms of vitamin C on the market at home and abroad, such as common tablets, capsules, effervescents, injections, granules, etc., but there is no report of transdermal patches. [0003] Transdermal patches, also known as transdermal therap...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/375A61P3/02A61P7/06A61P7/00
Inventor 顾世海
Owner 厦门蔚扬药业有限公司
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