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A micro-nano embedded particle based on piezoelectric droplet ejection and its preparation method

A micro-droplet jetting, micro-nano technology, applied in the field of medicine, can solve the problems of small jetting frequency of ink droplets, high ink requirements, etc., and achieve the effect of simple preparation method and equipment requirements, fast preparation speed and simple operation

Active Publication Date: 2020-05-19
云智前沿科技发展(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, compared with thermal foam printing, piezoelectric inkjet printing has the characteristics of smaller ink droplets and very high ejection frequency (fast speed), and is widely used in the image inkjet industry, but due to its impact on ink The requirements are high, and it is difficult to apply to the field of bioprinting

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0025] The method for preparing micro-nano embedded particles based on piezoelectric droplet spraying of the present invention includes the steps of dissolving prolamin, dissolving the drug to be embedded, and spray forming. The specific steps are as follows:

[0026] A. Dissolving gliadin: Add cereal gliadin into ethanol aqueous solution and stir until the solution is uniform and transparent to obtain gliadin solution;

[0027] B. The drug to be embedded is dissolved: take the drug to be embedded and add it to the above prolamin solution and stir until the solution is uniform and transparent to obtain a prolamin drug mixture;

[0028] C. Injection forming: the above-mentioned prolamin drug mixture is loaded into the liquid storage chamber of a printing device or a spraying device with a piezoelectric nozzle, and the printing device or spraying device is sprayed by the nozzle according to preset parameters to obtain micro-nano packets. Buried particles.

[0029] The step A is...

Embodiment 1

[0036] 1. Under normal temperature and pressure, weigh 30mg of zein, dissolve it in 30ml of 80% ethanol-water solution, stir it ultrasonically for 8-10min until the solution is uniform and transparent, and prepare about 1mg / ml of zein solution;

[0037] 2. Under normal temperature and pressure, weigh 9 mg of doxorubicin and dissolve it in the above-mentioned zein solution, stir it ultrasonically for 8-10 minutes until the solution is uniform and transparent, and prepare about 0.3 mg / ml doxorubicin zein alcohol Protein-dissolving mixture;

[0038] 3. Put the above doxorubicin zein mixture into the liquid storage chamber of the printing device or the spraying device with the ink droplet size of the piezoelectric nozzle being 1pL, and the printing device or the spraying device controls the liquid of the piezoelectric nozzle according to the preset parameters The size, velocity and morphology of the droplet were used to obtain doxorubicin micro-nano embedded particles with a diam...

Embodiment 2

[0040] 1. Under normal temperature and pressure, weigh 150mg of wheat prolamin, dissolve it in 30ml of 72% ethanol-water solution, stir it ultrasonically for 10-12min until the solution is uniform and transparent, and prepare about 5mg / ml of wheat prolamin solution;

[0041] 2. Under normal temperature and pressure, weigh 30 mg of ibuprofen and dissolve it in the above wheat prolamin solution, and stir it ultrasonically for 10-12 minutes until the solution is uniform and transparent, and prepare about 1 mg / ml of ibuprofen mixed with wheat prolamin liquid;

[0042] 3. Put the above-mentioned ibuprofen wheat prolamin mixture into the liquid storage chamber of the printing device or the spraying device with the ink droplet size of the piezoelectric nozzle being 10pL, and the printing device or the spraying device controls the droplets of the piezoelectric nozzle according to the preset parameters The size, velocity and morphology of the ibuprofen micronano-embedded particles wit...

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Abstract

The invention discloses piezoelectric droplet jetting-based micro-nano embedded particles and a preparation method thereof. The micro-nano embedded particles are obtained by putting alcohol soluble protein and drug mixed liquid with the cereal alcohol soluble protein concentration being 0.5 to 5 mg / ml and the to-be-embedded drug concentration being 0.2 to 1 mg / ml into a liquid storage cavity of aprinting or jetting device by jetting the alcohol soluble protein and drug mixed liquid through a piezoelectric jetting head. The preparation method comprises a dissolving step: adding cereal alcoholsoluble protein into an ethyl alcohol aqueous solution, and stirring till uniformly transparent alcohol soluble protein is obtained; a dissolving step: adding to-be-embedded drugs into the alcohol soluble protein solution, and stirring till the uniformly transparent to-be-embedded drugs are obtained; a jetting and forming step: adding the alcohol soluble protein and drug mixed liquid into the liquid storage cavity of the printing or jetting device, and jetting the alcohol soluble protein and drug mixed liquid through the jetting head of the printing or jetting device according to a preset parameter, thus obtaining the micro-nano embedded particles. The piezoelectric droplet jetting-based micro-nano embedded particles and the preparation method thereof have the characteristics that the method is simple, the speed is high, the cost is low, no toxic or side effects are caused, the particle size of the particles is uniform, and the biocompatibility is high.

Description

technical field [0001] The invention belongs to the technical field of medicines, and specifically relates to a micro-nano embedded particle based on piezoelectric droplet jetting and its Preparation. Background technique [0002] Controlled drug release is to use natural or polymer compounds as drug carriers to control the release rate of drugs in the human body, so that drugs can be released slowly within a certain time range and speed to achieve the purpose of treating a certain disease. Microencapsulation or microspheres is an important way of controlled drug release, which is widely used in the treatment of many diseases. Microcapsules or microspheres can maintain the concentration of drugs in the blood and carry drugs to special cells or tissues. In microencapsulation or microsphere technology, the core materials in different states are embedded by natural or synthetic polymer materials and can be released under certain conditions. Studies have shown that many differ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K45/00A61K47/42A61K31/704A61K31/192A61K31/337A61K33/24A61K31/513A61K38/28A61P35/00
Inventor 孙洪亮仇乐杜鑫石绮君刘爽贺婷婷张莹莹
Owner 云智前沿科技发展(深圳)有限公司
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