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Bismuth potassium citrate buccal adhesive tablet and preparation method thereof

A technology of potassium bismuth citrate and adhesive sheet is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., to achieve improved safety, no adverse reactions and side effects, and high usage compliance. sexual effect

Active Publication Date: 2018-01-16
SHIJIAZHUANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Potassium bismuth citrate has been marketed in dosage forms in my country: capsules, granules, oral solutions, chewable tablets, etc., but it is only used to treat ulcers in the gastrointestinal area. Currently, potassium bismuth citrate has not been developed for the treatment of oral ulcers in China. drug

Method used

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  • Bismuth potassium citrate buccal adhesive tablet and preparation method thereof
  • Bismuth potassium citrate buccal adhesive tablet and preparation method thereof
  • Bismuth potassium citrate buccal adhesive tablet and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Bismuth Potassium Citrate Oral Adhesive Tablets (100,000 pieces) of the present invention

[0026]

[0027]

[0028] Preparation Process:

[0029] (1) After passing the prescription amount of bismuth potassium citrate and dextrin through a 60-mesh sieve, set aside;

[0030] (2) Mix the sifted bismuth potassium citrate and dextrin for 15 minutes until evenly mixed to obtain mixed powder 1;

[0031] (3) the prescription amount of polyvinylpyrrolidone K30 Make a 2% solution with water as a binder; put the mixed powder 1 in a fluidized bed granulator and spray it into the binder to granulate, the powder is completely dried at 75°C, and the obtained granules are passed through a 20-mesh sieve for granulation , to obtain intermediate 1;

[0032] (4) The prescribed amount of carbomer 974P , sodium carboxymethyl starch, magnesium stearate, and micropowder silica gel were passed through an 80-mesh sieve, and mixed with Intermediate 1 for 15 minutes to obta...

Embodiment 2

[0036] Embodiment 2 Bismuth Potassium Citrate Oral Adhesive Tablets (100,000 pieces) of the present invention

[0037]

[0038] Preparation Process:

[0039] (1) After passing the prescription amount of bismuth potassium citrate through an 80 mesh sieve and starch through a 40 mesh sieve, set aside;

[0040] (2) Mix the sifted bismuth potassium citrate and starch for 15 minutes until they are evenly mixed to obtain mixed powder 1;

[0041] (3) the prescription amount of polyvinylpyrrolidone K30 Prepare a solution with purified water as a binder; put the mixed powder 1 in a fluidized bed granulator and spray the binder into granules, the powder is completely dried at 75°C, and the obtained granules are passed through a 20-mesh sieve for granulation to obtain Intermediate 1;

[0042] (4) The prescribed amount of carbomer 974P , sodium carboxymethyl starch, magnesium stearate, and micropowder silica gel are passed through an 80-mesh sieve, and placed in a planetary mixer w...

Embodiment 3

[0046] Embodiment 3 Bismuth Potassium Citrate Oral Adhesive Tablets (100,000 pieces) of the present invention

[0047]

[0048] Preparation Process:

[0049] (1) After passing the prescription amount of bismuth potassium citrate through an 80-mesh sieve and dextrin through a 60-mesh sieve, set aside;

[0050] (2) Mix the sifted bismuth potassium citrate and dextrin for 15 minutes until they are evenly mixed to obtain mixed powder 1;

[0051] (3) the prescription amount of polyvinylpyrrolidone K90 Use 75% ethanol to make a solution as a binder. Put the mixed powder 1 in a fluidized bed granulator and spray it with a binder for granulation. The powder is completely dried at 75°C, and the obtained granules are passed through a 20-mesh sieve for granulation to obtain intermediate 1;

[0052] (4) The prescribed amount of carbomer 974P , sodium carboxymethyl starch, magnesium stearate, and micropowder silica gel are passed through an 80-mesh sieve, and placed in a planetary m...

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Abstract

The invention relates to a bismuth potassium citrate buccal adhesive tablet and a preparation method thereof, and belongs to the technical field of medicinal preparation. For every 100,000 bismuth potassium citrate buccal adhesive tablets, the drug containing layer is prepared from the following components in parts by weight: 1000 to 2500 parts of bismuth potassium citrate, 1000 to 1100 parts of disintegrating agent, 120 to 152 parts of film forming agent, 60 to 100 parts of adhesive, 4.5 to 6.5 parts of flow aid, 25 to 45 parts of lubricant, and 440 to 560 parts of diluent, and the protectivelayer is prepared from the following components in parts by weight: 150 to 250 parts of polyvinyl alcohol and 0.8 to 1.5 parts of lemon yellow pigment. The provided bismuth potassium citrate buccal adhesive tablet enriches the kinds of conventional drugs for treating dental ulcer and is suitable for infants and people with allergic physique.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an oral adhesive tablet with bismuth potassium citrate as the main component and a preparation method thereof. Background technique [0002] Oral ulcers, also known as "oral sores", are a very common oral mucosal disease. Especially when "recurrent oral ulcer" broke out, it brought misery to the patient's life. The specific manifestations of this disease are: superficial ulcers on the mucosa, the ulcer surface is slightly concave like the bottom of a dish, there is spontaneous pain or pain caused by food stimulation, and it can usually heal on its own within 7 to 10 days. Ulcers often occur in the tongue or buccal mucosa, lip mucosa and palate, and sometimes spread to the corners of the mouth and throat. Sometimes the ulcers form into sheets, which can cause swelling of the mandibular lymph nodes, blush around, and very painful, especially when encountering sour, salty,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/32A61K31/194A61K47/32A61P1/02
Inventor 常明于宏伟郧海丽李铮
Owner SHIJIAZHUANG UNIVERSITY
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