A biosensing system based on elasto-optic modulation with 45° dual-drive symmetric structure

Abstract

The invention relates to the field of biosensing technology, concretely relates to a biological sensing system based on 45-degree dual drive symmetrical structure photoelastic modulation, and the system realizes original position, rapid, high precision, high sensitivity, high repeatability, low cost, and control convenience during measurement process. The system comprises the following components:detection laser, a polarizer, a biochemical reaction tank, a microflow syringe pump, an adjustable slit, a photoelastic modulator, a polarization analyzer, a photoelectric detector, an FPGA control module, and a control computer; the biochemical reaction tank is packaged by semicylindrical mirrors and silicon wafers at interval with PDMS; a flowing channel and an outputting channel are also constructed, two channels are connected to the microflow syringe pump, the photoelastic modulator is a photoelastic modulator with a 45-degree dual drive symmetrical structure, the structure comprises a dual drive piezo electric crystal and a photoelastic crystal which form a 45 degree angle, and the piezo electric crystal is connected to an FPGA control module by an LC resonance high voltage control circuit. The product is mainly applied to the aspect of biosensing.

Description

Technical field [0001] The present invention relates to the technical field of biosensing, and more specifically, to a biosensing system based on 45° dual-drive symmetrical structure elastic-light modulation. The system is an in-situ, fast, high-precision, high-sensitivity, low Cost of biosensing system. Background technique [0002] Observation of biometrics and combined activities is crucial to the medical, pharmaceutical and biotechnology fields. The vast majority of metabolic and immune effects are formed by interactions between biological molecules such as antibodies, DNA, RNA, proteins or whole cells. The information on the binding of ligand biomolecules and receptor biomolecules can provide guidance for drug development and accurate detection of disease biomarkers, and has been widely used in disease diagnosis and disease monitoring. In the past few decades, various sensing platforms have been used to determine the specificity, kinetics and affinity of various biomolecul...

AI Technical Summary

Problems solved by technology

In addition, interferometry and phase modulation methods are also used to measure the phase characteristics of SPR reflected light to improve SPR detection sensitivity, but the use of these methods makes the dynamic range of SPR detection limited

However, the instability of the environment, such as fluctuations in temperature, pressure, etc., will cause sensor false positive signals and inevitable noise

These problems of existing biosensors limit their application to low molecular weight, low concentration biomolecules, rapid, sample-free, high-precision and high-sensitivity detection

Images