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Method for manufacturing drug-containing biodegradable fiber material by electrospinning

A manufacturing method and fibrous technology, applied in the field of locally implanted slow-release agents in the body, and thermoplastic biodegradable resins are used as spinning solutions for electrospinning to prepare the field, which can solve the problems of carrier residues in the body and risks , to achieve excellent local sustained release and improve the effect of QOL

Inactive Publication Date: 2018-01-02
ORTHOREBIRTH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this case, the dispersion of the drug can be prevented, but there is a problem of the carrier remaining in the body, and there is no problem when the drug is applied to a site where it is relatively easy to remove the drug (such as a site under the skin), but the implantation of the drug in any part of the body is not a problem. Entry (embedding) is risky

Method used

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  • Method for manufacturing drug-containing biodegradable fiber material by electrospinning
  • Method for manufacturing drug-containing biodegradable fiber material by electrospinning
  • Method for manufacturing drug-containing biodegradable fiber material by electrospinning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0098] The present invention can be described in more detail with reference to the following Examples, Comparative Examples and Reference Examples, but is not limited to these Examples.

reference example 1

[0099] PLLA, β-tricalcium phosphate and Si-containing moletite phase calcium carbonate (40TCP-30SiV-30PLLA)

[0100] step 1

[0101] Drugs and polylactic acid are mixed and kneaded by a kneader. Preheat the kneader to The set temperature, and then 15g of poly L lactic acid pellets (PURAC PL24, molecular weight: Melting point: ) into the kneader, in Heat mixing and kneading at the set temperature for about 4 minutes. Then, a powder obtained by mixing 20 g of β-tricalcium phosphate powder and 15 g of SiV powder was added to a kneader, and the mixture was further mixed and kneaded at the same set temperature for about 10 minutes.

[0102] When heating at a set temperature of 180° C. to 190° C. of the kneader, mixing and kneading can be performed by applying torque from the kneader in this state. Although the state of the poly-L-lactic acid heated by the kneader is not completely clear, according to the speculation of the present inventors, it is considered that there...

reference example 2

[0115] β-tricalcium phosphate and PLLA (70TCP-30PLLA)

[0116] step 1

[0117] Knead β-tricalcium phosphate and poly-L-lactic acid (PURAC PL24, molecular weight: ).

[0118] Set the kneader set temperature to Preheat for 3 minutes, then add 15g of poly-L lactic acid pellets into the kneader, heat and knead at a set temperature of 180°C to 190°C for about 4 minutes. Then, 35 g of β-tricalcium phosphate powder was added to the kneader, and the two were mixed, and further kneaded at the same set temperature for about 10 minutes.

[0119] The mixture may be kneaded by applying torque from the kneader in this state while heating at a set temperature of 180° C. to 190° C. of the kneader. The state of the poly-L-lactic acid heated by the kneader is not completely clear. According to the estimation of the inventors of the present invention, it is considered that there are portions in a molten state having reached the melting point of poly-L-lactic acid itself and portions in a...

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Abstract

The present invention addresses the problem of providing a drug formulation material with which localized sustained release of a drug at any site in the body is possible, and which has good bioabsorption and is absorbed and broken down by the body after sustained release of the drug. A drug formulation material that has an exceedingly high sustained release effect, and that solves the foregoing problem, was successfully developed by dissolving a biodegradable resin and a drug in a solvent to prepare a spinning solution, and spinning fibers from the spinning solution by electrospinning.

Description

technical field [0001] This application claims priority to US Provisional Application No. 62 / 140722, filed March 31, 2015, the entire contents of which are incorporated by reference. [0002] The present invention relates to the preparation of thermoplastic biodegradable resins (polylactic acid, PLGA, etc.) containing powdery drugs (inorganic particles for bone formation, anticancer agents, antibiotics, etc.) as spinning solutions for electrospinning Methods. [0003] The present invention also relates to a method for producing a biodegradable fiber by electrospinning using the spinning solution for electrospinning produced by the above method. [0004] The present invention also relates to a method for efficiently recycling the biodegradable fiber produced by the above method as non-woven fabric (nonwoven fabric) or cotton. [0005] The present invention relates to a locally implanted (embedded) type slow-release (sustained-release) agent comprising the bioabsorbable cotton...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/34A61L31/00D01D5/08D01F1/10D01F6/92D04H1/728D04H3/011
CPCA61L31/00A61K47/34D04H1/728D01F1/10A61K9/0024A61K9/70D01D5/0046D01F6/625D04H1/42A61K31/282A61K31/704A61K31/7048A61P19/08A61P35/00D04H3/011D01F6/92A61L31/06A61L31/148A61L31/16A61L2300/416D01D5/0023D01D5/0076D01D7/00D10B2331/041D10B2509/00
Inventor 西川靖俊牧田昌士长田直生
Owner ORTHOREBIRTH
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