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A device for guiding bone regeneration

A guided bone regeneration and biological technology, applied in medical science, prosthesis, dental restoration, etc., can solve problems such as extra trauma, maintenance of bone repair space, and iatrogenic complications

Active Publication Date: 2021-07-30
NEO MODULUS SUZHOU MEDICAL SCI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in cases of buccal position or bone height defects, relying solely on guided bone regeneration membranes is not enough to maintain the bone repair space, and it is necessary to implant titanium mesh, autologous block bone and other rigid materials to support the bone repair space.
Among them, rigid materials such as titanium mesh and autologous bone need to be removed by secondary surgery; this may cause additional trauma, iatrogenic complications and other problems, and there is no ideal solution at present

Method used

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  • A device for guiding bone regeneration
  • A device for guiding bone regeneration
  • A device for guiding bone regeneration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] This embodiment provides an exemplary guided bone regeneration device with a double-layer structure. Such as figure 1 As shown, the guided bone regeneration device of this embodiment is composed of a layer of support layer 2 and a guide bone regeneration membrane 1 arranged on the entire surface of one side of the support layer 2, wherein the guide bone regeneration membrane 1 is used to cover the Repair parts. Wherein, the guiding bone regeneration membrane 1 and the support layer 2 are connected by bonding, and the guiding bone regeneration membrane 1 is made of fibrin into a planar sheet by 3D printing. The supporting layer 2 is made of polycaprolactone (PCL) by electrospraying into a planar sheet with a thickness of 1 mm.

[0027] The guided bone regeneration device of this example has a certain degree of support. At the same time, the fibrin and PCL materials used to make the guided bone regeneration membrane and support layer of the guided bone regeneration dev...

Embodiment 2

[0029] This embodiment provides an exemplary guided bone regeneration device with a sandwich structure. Such as figure 2 As shown, the guided bone regeneration device of the present embodiment consists of one deck of support layer 2 and one deck of guide bone regeneration film 1 respectively arranged on the entire surface of the support layer 2 both sides (that is, guide bone regeneration film-support layer - structure of the membrane that guides bone regeneration). Wherein, the guided bone regeneration membrane 1 is formed by electrospinning of collagen and made into a planar sheet. The support layer 2 is made of polyglycolic acid (PGA) into a grid shape by electrospinning, and its thickness is 1.5 mm. The supporting layer 2 and the guiding bone regeneration membrane 1 arranged on both sides thereof are connected by suturing with absorbable sutures, thereby forming a sandwich structure guiding bone regeneration device.

[0030] The guided bone regeneration device of this ...

Embodiment 3

[0032] This embodiment provides an exemplary guided bone regeneration device with a four-layer structure. Such as image 3 As shown, the guided bone regeneration device of this embodiment is composed of two laminated support layers 2 and guided bone regeneration membranes 1 respectively arranged on the entire surfaces of both sides of the laminated support layers, that is, guided bone regeneration membrane-support layer - Support layer - the structure of the membrane that guides bone regeneration. Among them, the guided bone regeneration membrane 1 is made of polysaccharide and formed into a planar sheet by 3D printing. The supporting layer 2 is made of polylactic-glycolic acid (PLGA), and formed into a strip shape by electrospinning, and its thickness is 0.5 mm. In addition, in this embodiment, the bone-guiding regeneration film further includes calcium phosphate with a weight percentage of 40%, and the supporting layer further includes calcium phosphate with a weight percent...

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Abstract

This article provides a guided bone regeneration device for bone repair and a preparation method thereof. The guided bone regeneration device provided herein includes a support layer and a guided bone regeneration film, wherein the guide bone regeneration film covers at least part of the surface of the support layer, and is used to cover the site to be repaired; and, wherein the support layer And the guided bone regeneration film has bioabsorbability. The guided bone regeneration device of the present invention is self-supporting, can be degraded in the human body as a whole, has good affinity with autologous tissue, and avoids the need for secondary surgery to remove the titanium that supports the bone repair space in the current existing bone repair surgery. The operation of materials such as mesh can further avoid problems such as additional trauma and iatrogenic complications.

Description

technical field [0001] The invention relates to a guiding bone regeneration device, in particular, the invention relates to a supporting and bioabsorbable guiding bone regeneration device. Background technique [0002] Guided bone regeneration refers to covering the bone defect with a layer of polymer biofilm as a barrier to ensure the repair of the bone defect. Such biofilms are classified into two categories: absorbable and nonabsorbable. Non-absorbable membranes are represented by polytetrafluoroethylene membranes, which must be removed by secondary operations when used, which brings great pain to patients, and because of their inactivity, they cannot be used for tissue regeneration with large defect areas, which limits the use of non-absorbable membranes. range of clinical use. The absorbable degradable membrane does not need to be taken out after being implanted in the body, which reduces the pain of the patient and the difficulty of the operation, so it is widely use...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58
CPCA61C8/00A61C8/0089
Inventor 董佳桓张婷婷
Owner NEO MODULUS SUZHOU MEDICAL SCI TECH CO LTD
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